Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Study of Diurnal Variation of Pulmonary Function Test


Affiliations
1 Dept of Physiology, SSIMS & RC Davangere
2 II Phase MBBS, SSIMS & RC Davangere, Karnataka
     

   Subscribe/Renew Journal


Pulmonary function has circadian rhythm in humans proven in diseased in conditions. These variations will contribute to better understanding the relationship between biorhythms and lung physiology for better management of pulmonary diseases.To study PFT in medical students during different time of the day and to study whether there is diurnal variation in PFT .The I MBBS students chosen as subjects were apparently normal and non-smokers. The study group included 113 students. They underwent PFT during different time of the day, i.e., at 6am, 11am, 4pm and 9pm. PFT was done using computerized Spirometer and the parameters studied were FEV1, FVC, FEV1/FVC, PEF, FEF25- 75% and FEF.2-1.2L. The data was tabulated and statistically analyzed. There were changes in all the PFT parameters recorded during different time of the same day. Mean of FEV1 and FVC were highest in the recording taken at 9:00pm. % change noted was 1.74% and 1.32% respectively, when compared to the recording at 6:00am. Mean of FEV1/FVC ratio also showed diurnal rhythm with highest % at 11:00am and lowest % at 6:00am. The % change noted was 0.76%. Mean of PEFR, FEF25-75% and FEF0.2-1.2L showed diurnal rhythm. They were high in the recording done at 4:00pm and low in the recording done at 6:00am. % change noted in PEFR, FEF25-75% and FEF.2-1.2L were 2.25%, 3.66% and 2.08% respectively. % change noted for each parameter was statistically not significant. The diurnal variation in PFT parameters is noted in healthy subjects. The % change noted is minimal in young healthy individuals. This diurnal rhythm amplitude increase in asthma and bronchitis patients.

Keywords

PFT, Computerized Spirometer, Diurnal Variation
Subscription Login to verify subscription
User
Notifications
Font Size


  • Klein D.C, Moore R.Y and Reppert S.M: Suprachiasmatic Nucleus: The Mind’s clock. Oxford University Press, New York. 1991.

  • Ralph M.R, Foster R.G, Davis F.C, Menaker M: Transplanted suprachiasmatic nucleus determines circadian period. Science 1990; 247: 975-978.

  • Sangoram A.M, Saez L, Antoch M.P, Gekakis N, Staknis D, Whiteley A, Fruechte E.M, Vitaterna N.H, Shimomura K, King D.P, Young M.W, Weitz C.J, Takahashi J.S: Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact nad negatively regulate CLOCK-BMAL1- induced transcription. Neuron 1998; 21: 1101- 1113.

  • Cardone L, Hirayama J, Giordano F, Tamaru T, Palvimo J.J, Sassone-Corsi P: Circadian clock control by SUMOylation of BMAL1. Science 2005; 309: 1390-1394.

  • (6)Hetzel M.R: The pulmonary clock. Thorax 1981; 36: 481-486.

  • Turner-Warwick, M. The definition and recognition of nocturnal asthma (with discussion). In P. J. Barnes and J. Levy, editors. Nocturnal Asthma. Oxford University Press, Oxford. 1984; 3–9.

  • Turner-Warwick, M. The management of chronic asthma. In P. J.Barnes, I. W. Rodger,and N. C. Thomson, editors. Asthma: Basic Mechanisms and Clinical Management. Academic Press Limited, London. 1988; 721–732.

  • Anonymous. Asthma at night (editorial). Lancet, 1983; 1:220–222.

  • Bateman, J. R. M., and S. W. Clarke.. Sudden death in asthma. Thorax 1979; 34:40–44.

  • Storms, W. W., S. F. Bodman, R. A. Nathan, and P. Byer Nocturnal asthma symptoms may be more prevalent than we think. J. Asthma . 1994; 31: 313–318.

  • Guberan, E., M. K. Williams, J. Walford, and M. M. Smith. Circadian variation of F.E.V. in shift workers. Br. J. Ind. Med. 1969; 26:121–125.

  • Hetzel, M. R., and T. J. H. Clark. Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate. Thorax1980; 35:732–738.

  • Kerr, H. D. Diurnal variation of respiratory function independent of air quality: experience with an environmentally controlled exposure chamber for human subjects.Arch. Environ. Health 1973; 26:144–152.

  • Medarov B.I, Pavlov V.A, Rossof L. Diurnal variations in human pulmonary function. Int J Clin Exp Med 2008; 1: 267-273.

  • Aggarwal A.N, Gupta D, Chaganti S, Jindal S.K. Diurnal variation in peak expiratory flow in healthy young adults. Indian J Chest Dis Allied Sci 2000; 42: 15-19.

  • Borsboom G.J.J.M, Pelt W, Houwelingen H.C, Vianen B.G, Schouten J.P, Quanjer P.H Am J Respir Crit Care Med 1999; 159:1163-1171.

  • Patil J.D, Rupwate R.U, Kolhatkar V.P, Potdar P.V, Kamat S.R. Comaprison of diurnal variations in normals, bronchial asthmatics and chronic bronchitics. Lung India1989Aug; 7(3): 107-111.

  • Larsson K, Hedenstrom H, Malmberg P. Learning effects, variation during office hours and reproducibility of static and dynamic spirometry. Respiration 1987; 51(3): 214-222.

  • Hruby J, Butler J. Variability of routine pulmonary function tests. Thorax 1975; 30:548-553.

  • Bernard R, Fundamentals of Biostatistics, 5th Ed, Duxbury; 2000.

  • Reddy MV. Statistics for mental health care research. India: NIMHANS publication; 2002


Abstract Views: 348

PDF Views: 0




  • Study of Diurnal Variation of Pulmonary Function Test

Abstract Views: 348  |  PDF Views: 0

Authors

B K Prasad
Dept of Physiology, SSIMS & RC Davangere
B L Ashika
II Phase MBBS, SSIMS & RC Davangere, Karnataka

Abstract


Pulmonary function has circadian rhythm in humans proven in diseased in conditions. These variations will contribute to better understanding the relationship between biorhythms and lung physiology for better management of pulmonary diseases.To study PFT in medical students during different time of the day and to study whether there is diurnal variation in PFT .The I MBBS students chosen as subjects were apparently normal and non-smokers. The study group included 113 students. They underwent PFT during different time of the day, i.e., at 6am, 11am, 4pm and 9pm. PFT was done using computerized Spirometer and the parameters studied were FEV1, FVC, FEV1/FVC, PEF, FEF25- 75% and FEF.2-1.2L. The data was tabulated and statistically analyzed. There were changes in all the PFT parameters recorded during different time of the same day. Mean of FEV1 and FVC were highest in the recording taken at 9:00pm. % change noted was 1.74% and 1.32% respectively, when compared to the recording at 6:00am. Mean of FEV1/FVC ratio also showed diurnal rhythm with highest % at 11:00am and lowest % at 6:00am. The % change noted was 0.76%. Mean of PEFR, FEF25-75% and FEF0.2-1.2L showed diurnal rhythm. They were high in the recording done at 4:00pm and low in the recording done at 6:00am. % change noted in PEFR, FEF25-75% and FEF.2-1.2L were 2.25%, 3.66% and 2.08% respectively. % change noted for each parameter was statistically not significant. The diurnal variation in PFT parameters is noted in healthy subjects. The % change noted is minimal in young healthy individuals. This diurnal rhythm amplitude increase in asthma and bronchitis patients.

Keywords


PFT, Computerized Spirometer, Diurnal Variation

References