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Gupta, Geeta
- Comparative Study of the Therapeutic Efficacy of the Dapsone (Alone), Dapsone Plus Tacrolimus (Topical) and Dapsone Plus Triamcinolone (Topical) in Oral Lichen Planus
Authors
1 Department of Dermatology, Santosh Medical College, Ghaziabad (UP), IN
2 Department of Microbiology, Santosh Medical College, Ghaziabad (UP), IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 1 (2013), Pagination: 83-86Abstract
Background: Oral lichen planus (OLP) is a common, chronic inflammatory condition, which frequently present with symptoms of pain and irritation. OLP is difficult to manage. Existing clinical trials have shown that oral Dapsone and topical corticosteroids are often effective in the management of OLP. However, Tacrolimus has recently been shown to be an effective treatment of OLP without any side effects.
Objective: The purpose of this study was to compare the efficacy and safety of Dapsone (alone), Dapsone + Tacrolimus (topical) and Dapsone +Triamcinolone (topical) in management of OLP. Material and Method: In this randomized comparative double-blind study, 57 patients with oral lesions consistent clinically and histologically with OLP were recruited. Patients were divided into three groups of 17 and 22 & 18. In group-1, 17 patients were given oral Dapsone alone. In group-2, 22 patients were given oral Dapsone and topical Tacrolimus (0.1%).while in group 3, 18 patients were given oral Dapsone with topical Triamcinolone acetonide (0.1%).
Results: Group 2 in which oral Dapsone and topical Tacrolimus (0.1%) given showed the best results i.e. good response shown by 45.45% patients and excellent response shown by 36.36% patients without any major side effects.
Conclusions: The study showed that Dapsone in combination with topical Tacrolimus ointment (0.1%) is safe, well tolerated, and effective therapy for OLP
Keywords
Dapsone, Oral Lichen Planus, Topical Therapy, Tacrolimus Ointment, Triamcinolone AcetonideReferences
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- Prevalence of Candidiasis, Trichomoniasis and Bacterial Vaginosis among Women of Reproductive Age Group
Authors
1 Department of Microbiology, Santosh Medical College and Hospital, Ghaziabad (UP)
2 Department of Microbiology, ESI-PGIMSR, ESI Hospital, New Delhi,India
3 Department of Obstetrics and Gynaecology, Santosh Medical College & Hospital, Ghaziabad (UP)
Source
Indian Journal of Public Health Research & Development, Vol 4, No 2 (2013), Pagination: 94-98Abstract
Background: Vaginal symptoms are leading reason for patients to visit gynecologist. Few data are available on prevalence of different causes of vaginitis.
Objective: To find out prevalence of Candidiasis, Trichomoniasis and bacterial Vaginosis among the women of reproductive age group.
Method: 400 sexually active married women attended gynecology OPD and ANC clinic at Santosh Hospital, Ghaziabad included in study. Participants were interviewed and structured questionnaire were filled. Two high vaginal swabs were collected from each woman. One swab was used for making smear and other used for culture on SDA. Candidiasis was detected by presence of curdy white discharge, Gram stain and culture on SDA. Trichomoniasis was detected by presence of green yellow frothy discharge, Wet mount and Papanicolaou stain. Bacterial Vaginosis was detected by presence of homogenous white or grey discharge, Amsel method and Gram stain.
Results: Over all prevalence of vaginitis was 47.75 %. The prevalence of Candidiasis was 54.5% by Gram stain and 21.5% by culture method. The prevalence of Trichomoniasis was 12% by Wet mount and 8.75% by Pap stain. The prevalence of bacterial Vaginosis was 24% by Amsel criteria and 29% by Gram stain.
Conclusions: This study raised an awareness regarding high vulnerability of women in reproductive age group for vaginitis. The study reveals that prevalence of candidiasis is 21.5%, trichomoniasis 8.75% and bacterial vaginosis 29% .
Keywords
Vaginitis, Prevalence, Candidiasis, Trichomoniasis, Bacterial Vaginosis, Reproductive Tract InfectionReferences
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