Indian Journal of Public Health Research & Development

Dharmashree Satyarup ¹, Manish Kumar ¹, Radha Prasanna Dalai ², Sashikant Sethy ¹, Karishma Rathor ¹

Affiliations
1 Department of Public Health Dentistry, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Public Health Dentistry, GITAM Dental College and Hospital, Visakhpatanam, Andhra Pradesh, IN

Abstract

Errors occur in research either from ignorance or neglect. These when present undermine the generalizability of the study and compromise its authenticity. The list of errors in research is exhaustive but an attempt is made to list the most common methodological errors and the ways to prevent them.

Keywords

Error, Bias, Research, Methodology, Study Design.

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Amit Yadav ¹, Prabhat Kumar Upadhyay ², Manish Kumar ³, Vishal Kumar Vishwakarma ⁴, A. Pandurangan ³, Pradeep Mishra ⁵

Affiliations
1 Research Scholar, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, IN
2 Associate Professor, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, IN
3 Professor, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, IN
4 Research Associate, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, IN
5 Professor, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, IN

Abstract

Background: Alzheimer’s disease (AD), a category of neurological degeneration generally seen in elderly people which is reflected by memory loss and affecting daily living activities.

Method: The data has been accessed from scopus, pubmed, science-direct and google-scholar which is included in this article.

The literature provide the information about pathological alterations of Alzheimer disease emphasizing on formation of neuritic plaques, beta amyloid protein, neurofibrillary tangle and also updates therapeutics used in Alzheimer’s disease including cholinesterase inhibitors, ACE inhibitors, NMDA receptor antagonists, secretase inhibitors and anti-inflammatory drugs, herbal drugs and other naturals.

Results: The research on neuropathology and diagnosis of Alzheimer’s disease are determinants of this study. The pathophysiology, diagnosis using biomarkers and therapeutics of disease has been summarized.

Conclusion: The aim of this review paper is to focus on how diagnosis and pharmacotherapy of Alzheimer’s disease useful for researchers engaged in the experimental research.

Keywords

Alzheimer’s Disease, β-amyloid Precursor Protein, Neurofibrillary Tangles, Acetylcholinesterase Inhibitors, Secretase Inhibitors, Biomarkers.

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Amit Yadav ¹, Prabhat Kumar Upadhyay ², Manish Kumar ³, Vishal Kumar Vishwakarma ⁴, A. Pandurangan ³, Pradeep Mishra ⁵

Affiliations
1 Research Scholar, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, IN
2 Associate Professor, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, IN
3 Professor, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, IN
4 Research Associate, Department of Pharmacology, All India Institute of Medical sciences, New Delhi, IN
5 Professor, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, IN

Abstract

Background: Alzheimer’s disease (AD), a category of neurological degeneration generally seen in elderly people which is reflected by memory loss and affecting daily living activities.

Method: The data has been accessed from scopus, pubmed, science-direct and google-scholar which is included in this article. The literature provide the information about pathological alterations of Alzheimer disease emphasizing on formation of neuritic plaques, beta amyloid protein, neurofibrillary tangle and also updates therapeutics used in Alzheimer’s disease including cholinesterase inhibitors, ACE inhibitors, NMDA receptor antagonists, secretase inhibitors and anti-inflammatory drugs, herbal drugs and other naturals.

Results: The research on neuropathology and diagnosis of Alzheimer’s disease are determinants of this study. The pathophysiology, diagnosis using biomarkers and therapeutics of disease has been summarized.

Conclusion: The aim of this review paper is to focus on how diagnosis and pharmacotherapy of Alzheimer’s disease useful for researchers engaged in the experimental research.

Keywords

Alzheimer’s Disease, ±-Amyloid Precursor Protein, Neurofibrillary Tangles, Acetylcholinesterase Inhibitors, Secretase Inhibitors, Biomarkers.

Full Text