Indian Journal of Public Health Research & Development

Vini Mehta ¹, Sahana Hegde-Shetiya ¹, Pradnya Kakodkar ¹, Nitin Gupta ¹

Affiliations
1 Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, IN

Abstract

Introduction: Regulatory guidelines have been made stringent to safeguard human rights, integrity, safety and welfare.

Aim and Objective: The present study was designed to elucidate the knowledge and practice of current regulatory requirements for the members of ethics committee (EC), amongst dental colleges in India.

Materials and Method: A cross sectional survey was conducted amongst the ethics committee members of various post graduate dental colleges representing North, South, East, West and Central zones. A validated closed questionnaire was framed in accordance with the Schedule Y of Drugs and Cosmetic Rules 1945 and Indian-GCP guidelines, which was sent through an e-survey using Google forms.

Results: The response rate was found to be 40%. Less than 50% participants correctly answered about guidelines of biomedical research, composition of EC, serious adverse effect and vulnerable population. 16.3% of the participants had registered EC and only 28.7% applied universal ethical principles.

Conclusion: Despite the presence of ethics committee in the dental institute, the knowledge and practice regarding current regulatory requirements was found to be insufficient for proper functioning.

Keywords

Ethics, Current Regulatory Requirements, Dental Colleges.

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Sneh Lata ¹, Rosy Bala ², Neerja Jindal ³, Nitin Gupta ⁴

Affiliations
1 Senior Resident, Department of Microbiology, GGS Medical College, Faridkot (Punjab), IN
2 Assistant Professor, Department of Microbiology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Maharishi Markandeshwar (Deemed to be University), IN
3 Professor & Head, Department of General Medicine, IN
4 Assistant Professor, Department of General Medicine, IN

Abstract

Backround: Serious infections due to methicillin resistant Staphylococcus aureus (MRSA) have become a major clinical challenge. Globally Macrolide-lincosamide streptogramin B family of antibiotics are commonly used to treat such infections as an alternative to vancomycin. The study was to conducted to find out the presence of inducible clindamycin resistance among Staphylococcus aureus and their association with methicillin resistance.

Method: The study conducted over one year (Jan 2016 - Dec 2016) in microbiology department of Guru Gobind Singh Medical College, Faridkot. Two hundred fifteen S.aureus isolates were included in the study. Methicillin resistance was detected by cefoxitin (30μg) disc diffusion method and inducible clindamycin resistance by erythromycin and clindamycin disc approximation test (D-Test).

Results: Of the 215 clinical isolates of S. aureus, 140 (65.11%) were MRSA. Erythromycin and clindamycin resistance was seen in 79.06%(170/215) and 49.30% ( 106/215) respectively. Resistance to erythromycin and clindamycin were higher in MRSA than MSSA (erythromycin resistance:100%v s 22.5% and Clindamycin resistance:70.1% vs 10.6%). Both iMLSB and cMLSBphenotypes are predominant in MRSA.

Conclusion: Detection of MRSA in our study shows the need to improve health care practices and to formulate new infection control policies to control MRSA infections. Inducible and constitutive resistance is comparatively higher in our study in MRSA .So It is necessary to perform D-test for detection of inducible clindamycin resistance among MRSA in routine antibiotic sensitivity testing so that therapeutic failures can be avoided.

Keywords

Staphylococcus aureus, MRSA, Inducible Clindamycin resistance, D-Test.

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Nitin Gupta ¹, Rosy Bala ², Varsha A. Singh ³, Harit Kumar ⁴, Shavi Nagpal ², Sonia Mehta ³

Affiliations
1 Assistant Professor, Department of General Medicine, M.M. Institute of Medical Sciences and Research, Mullana, Maharishi Markandeshwar (Deemed to be University), IN
2 Assistant Professor, Department of Microbiology, M.M. Institute of Medical Sciences and Research, Mullana, Maharishi Markandeshwar (Deemed to be University), IN
3 Professor, Department of Microbiology, M.M. Institute of Medical Sciences and Research, Mullana, Maharishi Markandeshwar (Deemed to be University), IN
4 Tutor, Department of Microbiology, M.M. Institute of Medical Sciences and Research, Mullana, Maharishi Markandeshwar (Deemed to be University), IN

Abstract

Over the years we have seen many antibiotics have been developed, each one supposedly better than the previous, but still we have not been able to overcome the persistent problem of antibiotic resistance regardless of the potency of the drug. There is an urgent need to develop new antibiotic strategies to overcome this problem that is different from previous efforts. Hence a method should be focused on the area of inhibition of bacterial evolution for resistance-“evolution proof Antibiotics”.

Keywords

Antibiotics, miracle molecules, Anti microbial resistance (ARM), Evolution proof molecules, evolvability factor.

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Rosy Bala ¹, Nitin Gupta ², Shaveta Kataria ³, Sneh Lata ³, Puneet Saini ⁴, Ritu Garg ⁵

Affiliations
1 Assistant Professor, Department of Microbiology, MMIMSR, Maharishi Markandeshwar (Deemed to be University), Mullana, IN
2 Assistant Professor, Department of General Medicine, MMIMSR, Maharishi Markandeshwar (Deemed to be University), Mullana, IN
3 Senior Resident, Department of Microbiology, GGS Medical College, Faridkot, IN
4 Medical Officer, PCMS 1, CHC Bharatgarh, (Ropar), Punjab, IN
5 Associate Professor, Department of Microbiology, MMIMSR, Maharishi Markandeshwar (Deemed to be University), Mullana

Abstract

Violence against medical professionals at the workplace is not a new phenomenon. In recent times, the reports of doctors getting thrashed by patients or their relatives have made headlines around the world. Almost every doctor has experienced some kind of violence whether physical or verbal at certain stage of their profession. This article aims to discuss the risk factors associated with violence against doctors and the possible steps that are needed to prevent such incidents.

Keywords

Violence, medical professionals, Health care setting.

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