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Agarwal, Sachin
- Comparative Study of the Therapeutic Efficacy of the Dapsone (Alone), Dapsone Plus Tacrolimus (Topical) and Dapsone Plus Triamcinolone (Topical) in Oral Lichen Planus
Authors
1 Department of Dermatology, Santosh Medical College, Ghaziabad (UP), IN
2 Department of Microbiology, Santosh Medical College, Ghaziabad (UP), IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 1 (2013), Pagination: 83-86Abstract
Background: Oral lichen planus (OLP) is a common, chronic inflammatory condition, which frequently present with symptoms of pain and irritation. OLP is difficult to manage. Existing clinical trials have shown that oral Dapsone and topical corticosteroids are often effective in the management of OLP. However, Tacrolimus has recently been shown to be an effective treatment of OLP without any side effects.
Objective: The purpose of this study was to compare the efficacy and safety of Dapsone (alone), Dapsone + Tacrolimus (topical) and Dapsone +Triamcinolone (topical) in management of OLP. Material and Method: In this randomized comparative double-blind study, 57 patients with oral lesions consistent clinically and histologically with OLP were recruited. Patients were divided into three groups of 17 and 22 & 18. In group-1, 17 patients were given oral Dapsone alone. In group-2, 22 patients were given oral Dapsone and topical Tacrolimus (0.1%).while in group 3, 18 patients were given oral Dapsone with topical Triamcinolone acetonide (0.1%).
Results: Group 2 in which oral Dapsone and topical Tacrolimus (0.1%) given showed the best results i.e. good response shown by 45.45% patients and excellent response shown by 36.36% patients without any major side effects.
Conclusions: The study showed that Dapsone in combination with topical Tacrolimus ointment (0.1%) is safe, well tolerated, and effective therapy for OLP
Keywords
Dapsone, Oral Lichen Planus, Topical Therapy, Tacrolimus Ointment, Triamcinolone Acetonide
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