A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kadium, Tahrir Etihad
- The Association of Triglycerides Glucose Index with Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus
Authors
1 Al-Kindy College of Medicine, University of Baghdad, IQ
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 1885-1890Abstract
Aim: The aim of this study is to evaluate the association of the Triglycerides glucose index, (TyG index), a marker of insulin resistance, with diabetic retinopathy in patients with type 2 diabetes mellitus.
Method: This is a cross sectional study, carried out during the period from April 2016 to November 2017. 416 patients with type 2 diabetes mellitus were enrolled in this study (194 male and 222 female). Fasting blood sample was obtained to measure the blood glucose, glycated hemoglobin, and lipid profile. Patients were referred to ophthalmological assessment for the diagnosis of diabetic retinopathy. Body mass index and waist circumference were measured by standardized procedure. TyG index was calculated according to a published formula. Statistical analysis was performed by using SPSS
Results: Seventy patients had diabetic retinopathy (28 male and 42 female).TyG index was higher in patients with diabetic retinopathy, the prevalence of diabetic retinopathy increased across TyG index quartiles (p=0.000). The correlation between TyG index and the presence of retinopathy was significant (r = 0.247, P=0.000) after adjusting for the confounders. Area under the curve showed that TyG index has a good discriminating power to predict the presence of diabetic retinopathy.
Conclusion: TyG index could be used as an indicator of the presence of diabetic retinopathy. It shows a good association with diabetic retinopathy
Keywords
Triglycerides Glucose Index, Diabetic Retinopathy, Type 2 Diabetes Mellitus, Insulin Resistance.
- Impact of Serum Apolipoprotein B Measurements on the Risk Management of Atherosclerotic Cardiovascular Disease
Authors
1 Dept. of Clinical Biochemistry, University of Baghdad, IQ
2 Alkindy College of Medicine, University of Baghdad, IQ
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 2268-2274Abstract
Background: Studies have indicated that serum Apolipoprotein B (Apo B) was superior to LDL-C and Non-HDL-C in risk management of Atherosclerotic Cardiovascular Disease (ASCVD).
Objectives: The present study was designed to explore the impact of introducing serum Apo B measurement as an additional target, on antilipidemic treatment policy.
Methods: Patients attended the obesity research and therapy unit (ORTU), besides staff and undergraduate students at Al-Kindy College of Medicine, were participate in this cross-sectional study. Lipid profile and Apo B analysis were performed. Participants were stratified according to the classic major ASCVD risk factors endorsed by guidelines.
Results: Comparing (75) obese to (36) non-obese subgroups, significant differences were demonstrated in lipid profile parameters (P< 0.05). Serum Apo B levels were evidently higher in obese patients, (P> 0.05). In multiple regression model, Non-HDL-C was the only significant independent predictor of serum Apo B levels. According to guidelines, serum Apo B was a treatment target only for (9) patients. When serum Apo B was introduced as a third treatment target, additional antilipidemic treatments were need to be initiated in (36) out of the (69) participants already achieving treatment targets.
Conclusions: Introduction of Apo B measurement in the management of ASCVD increases the number of patients in whom antilipidemic treatment should be initiated. The extent of this increase is partially determined by the discordance rate between Apo B and LDL-C in the studied population.