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Kalaiselvi, V. S.
- Serum Hepcidin as a Marker of Anemia in Chronic Kidney Disease
Authors
1 Post Graduate, Department of Biochemistry, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, IN
2 Professor and HOD, Department of Biochemistry, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, IN
3 Professor, Department of Biochemistry, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 3928-3933Abstract
Background: In CKD, there is a dynamic and tenacious loss of renal capacity which at last leads on to end organize renal malady (ESRD). Sickliness is a typical confusion of CKD and creates before ESRD. Hepcidin is known to be the focal controller of iron homeostasis in the body. It is up-controlled by aggravation and downregulated by iron deficiency. Past work has demonstrated that serum hepcidin levels were expanded in patients with CKD. Comprehension of hepcidin hormone and its job in iron digestion could prompt new treatments for CKD-related frailty. It is conceivable that expanded hepcidin fixations may cause ironconfined erythropoiesis additionally in CKD-related pallor.
Aim and Objectives: The aim of the study is to estimate the levels of hepcidin in CKD patients and to check the correlation of hepcidin to anemia in chronic kidney disease.
Method: This cross-sectional investigation was led at the Department of Biochemistry, Central Laboratory, Sree Balaji Medical College and Hospital, Chromepet, Chennai during January 2017 - June 2018 among 50 patients of incessant kidney sickness in the age gathering of 18-60 years. The blood tests were gathered utilizing vacutainer framework. Tests for serum hepcidin, urea and creatinine were gathered in red bested plain vacuum tube. The examples were centrifuged at 3000 rpm for 15 minutes. The examples were then prepared, and qualities were gotten. The information were examined utilizing SPSS bundle.
Results: The mean values of s. Hepcidin and s. ferritin were found to be increased in the study population. The mean values of s. Iron, s. TIBC, s. Transferrin levels and hemoglobin were lower in the study population.
Conclusion: Hepcidin levels are elevated in CKD and hepcidin is a predictor of iron stores since it correlated well with the markers of iron status, serum iron and ferritin levels.
Keywords
Chronic Kidney Disease (CKD), Hepcidin.
- Serum Hepcidin Levels in Chronic Kidney Disease
Authors
1 Post Graduate, Department of Biochemistry, Sree Balaji Medical College an Hospital, Bharath Institute of Higher Education and Research, Chennai, IN
2 Professor and HOD, Department of Biochemistry, Sree Balaji Medical College an Hospital, Bharath Institute of Higher Education and Research, Chennai, IN
3 Professor, Department of Biochemistry, Sree Balaji Medical College an Hospital, Bharath Institute of Higher Education and Research, Chennai, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 3934-3937Abstract
Background: In CKD, the dynamic and tenacious loss of renal capacity which eventually leads on to end arrange renal malady (ESRD). Iron deficiency is a typical entanglement of CKD and creates before ESRD. Hepcidinis considered as the headliner of iron homeostasis in the body. It is up-managed by aggravation and downregulated by pallor. Past work has demonstrated that serum hepcidin levels were expanded in patients with CKD. This was astounding as these patients had a constant incendiary state and concurrent iron deficiency. It is conceivable that expanded hepcidin focuses may cause iron-confined erythropoiesis likewise in CKD-related weakness.
Aim and Objectives: The aim of the study is to estimate the levels of serum hepcidin in patients with chronic kidney disease.
Methods: This cross-sectional examination was directed at the Department of Biochemistry, Central Laboratory, Sree Balaji Medical College and Hospital, Chromepet, Chennai during January 2017 - June 2018 among 50 patients of incessant kidney illness in the age gathering of 18-60 years. The blood tests were gathered utilizing vacutainer framework. Tests for serum hepcidin, urea and creatinine were gathered in red bested plain vacuum tube. The examples were centrifuged at 3000 rpm for 15 minutes. The examples were then processed,and qualities were gotten. The information were investigated utilizing SPSS bundle.
Results: In CKD patients, serum hepcidin levels are found to be elevated and found to be positively correlating with serum urea and creatinine values.
Conclusion: Serum hepcidin levels are elevated in CKD patients which could be responsible for the iron restricted erythropoiesis and resistance to erythropoietin stimulating agents in CKD.