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Anti-inflammatory Potential of Dapsone Loaded Chitosan Nanoparticles in Streptozotocin-Induced Experimental Dementia


Affiliations
1 Punjabi University, Patiala,, India
2 PCTE Groups of Institutes, Ludhiana,, India
 

The potential of dapsone loaded characterized chitosan nanoparticles (CSNP) as a targeted delivery was investigated in memory deficits associated with dementia of Alzheimer disease type. Streptozotocin (STZ) in two doses (3 mg/kg on 1st and 3rd day) via intracerebroventricular route was used to induce dementia in swiss albino mice. The results showed that administration of STZ significantly impaired learning and memory based on Morris water-maze (MWM) test and raised myeloperoxidase (MPO) level along with neutrophils infiltration density (based on brain myeloperoxidase activity along with histological studies). Dapsone (1 mg/kg & 2 mg/kg for 11 days) loaded CSNP significantly attenuated STZ induced memory impairment as well as brain MPO activity along with increased neutrophils infiltration.
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  • Anti-inflammatory Potential of Dapsone Loaded Chitosan Nanoparticles in Streptozotocin-Induced Experimental Dementia

Abstract Views: 60  |  PDF Views: 58

Authors

V. Saluja
Punjabi University, Patiala,, India
D. Chopra
Punjabi University, Patiala,, India
N. Singh
Punjabi University, Patiala,, India
B.S. Sekhon
PCTE Groups of Institutes, Ludhiana,, India

Abstract


The potential of dapsone loaded characterized chitosan nanoparticles (CSNP) as a targeted delivery was investigated in memory deficits associated with dementia of Alzheimer disease type. Streptozotocin (STZ) in two doses (3 mg/kg on 1st and 3rd day) via intracerebroventricular route was used to induce dementia in swiss albino mice. The results showed that administration of STZ significantly impaired learning and memory based on Morris water-maze (MWM) test and raised myeloperoxidase (MPO) level along with neutrophils infiltration density (based on brain myeloperoxidase activity along with histological studies). Dapsone (1 mg/kg & 2 mg/kg for 11 days) loaded CSNP significantly attenuated STZ induced memory impairment as well as brain MPO activity along with increased neutrophils infiltration.

References