International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN)

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Analgesic and Anti-inflammatory Activity of Ficus glomerata in Experimental Animal Models


Affiliations
1 Shree Devi College of Pharmacy, Kenjar, Mangalore,, India
2 NGSM Institute of Pharmaceutical Sciences, Paneer, Mangalore,, India
 

The anti-inflammatory and analgesic activity of various extracts of Ficus glomerata Roxb. were evaluated in experimental animals. We have determined the anti-inflammatory and analgesic activity of various extracts of the dried fruits of Ficus glomerata by oral administration at doses of 200 and 400 mg/kg of body weight to healthy animals. The extracts were studied for their anti-inflammatory activity in carageenan induced hind paw edema in rats and the paw volume wasmeasured plethysmometrically after 3 hours of injection. The extracts were also evaluated for analgesic activity using Eddy’s hot plate method in mice. The extracts of Ficus glomerata significantly reduced carageenan-induced hind paw edema in rats. The extracts showed significant analgesic activity, evidenced by increase in the reaction time by the Eddy’s hot plate method in mice. The extracts showed a similar anti-inflammatory and analgesic effect compared to standard drugs indomethacin and diclofenac sodium, respectively. The present results indicated that the ethanolic extract of Ficus glomerata exhibited significantly more activity than other extracts in reducing the pain and inflammation in experimental models.

Keywords

Ficus glomerata; anti-inflammatory; analgesic; pain; paw edema; writhing.
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  • Chandana C, Jayanti D, Bhaben B, Acheenta G, Prabodh B and Mangala L (2011). Analgesic and antinociceptive activity of hydroethanolic extract of Drymaria cordata Willd. Ind J Pharmacol 43(2):121-125.

  • Channabasavaraj KP, Badami S and Bhojraj S (2008). Hepatoprotective and antioxidant activity of methanol extract of Ficus glomerata. J Nat Med 62:379-383.

  • Forestieri AM, Monforte MT, Ragusa S, Trovato A and Lauk L (1996). Anti-inflammatory, analgesic and antipyretic activity in rodents of plant extracts used in African medicine. Phytother Res 10(2):100-106.

  • Gracy M, Baby PS and Ancy J (2011). Standardization of conventional propagation techniques for four medicinal species of genus Ficus linn. Indian J Nat Prod Resour 2(1):88-96.

  • Kalpesh G, Nema R, Kori M, Sharma C and Virendra S (2008). Anti-inflammatory and analgesic activity of Balanites aegyptiaca in experimental animal models. Int J Green Pharm 214-217.

  • Kar A (2003). Pharmacognosy and Pharmabiotechnology, 2nd ed. New age International Publishers, India, pp 5-11.

  • Kar A, Choudhary BK and Bandyopadhyay NG (2003). Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 84(1):105-108. Khan N and Sultana S (2005). Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats. Life Sci 77:1194-1210.

  • Kokate CK, Purohit AP, Gokhale SB (2008). Pharmacognosy, Nirali Prakashan. 42nd ed. 1. pp.1-1.7

  • Mandal SC, Saha BP and Pal M (2005). Studies on anti-bacterial activity of Ficus racemosa extract Linn. Phytother Res 14:278- 280.

  • Mate GS, Naikwade NS, Magdum CS, Chowki AA and Patil SB (2008). Evaluation of anti-nociceptive activity of Cissus quadrungularis on albino mice. Int J Green Pharm 118-121.

  • Mohammed A, Koteshwar P, Licto T and Jagadish K (2007). Evaluation of analgesics and anti-inflammatory activity of Sudard, a poly-herbal formulation. Iran J Pharmacol Ther 6(1):71-75.

  • Nadkarni KM (2002): Indian Materia Medica, Bombay Popular Prakashan: 1, pp 518-548.

  • OECD/OCED 423 (2001). OECD guidelines for testing of chemicals-acute oral toxicity-up and down procedure: Dec 17, 1-26.

  • Pulok KM, Das J, Balasubramanian R, Kakali S, Pal M and Saha BP (1996). Preparation and evaluation of a herbal uterine tonic. Phytother Res 10(7):619-621.

  • Rao CH, Verma AR, Vijayakumar M and Rastogi S (2008). Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats. J Ethnopharmacol 17:115(2):323-326.

  • Sandhya S, Sudhakar K, Vinod , Banji D, Banji O, Saikiran M (2011). Evaluation of analgesic, anti-inflammatory and membrane stabilizing potency of female plant of Borassus flabellifer L. Indian Drugs 48(04):36-41.

  • Shikha P, Latha PG, Suja SR, Anuja GI, Shyamal S, Shine VJ, Sini S, Krishnakumar NM and Rajasekharan S (2010). Anti-inflammatory and analgesic activity of Barringtonia racemosa Roxb. fruits. Ind J Nat Prod Resour 1(3):356-361.

  • Somnath N, Sandeep B, Nilophar S and Chandrakant S (2008). Evaluation of anti-nociceptive and anti-inflammatory activity of stems of Gynandropsis pentaphylla Linn. Int J Green Pharm 87- 90.

  • Sreelekshmi R, Latha P, Arafat M, Shyamal S, Shine V, Anuja G, Suja S and Rajasekharan S (2007). Anti-inflammatory ,analgesic and anti-lipid peroxidation studies on stem bark of Ficus religiosa Linn. Nat Prod Rad 6(5): 377-381.

  • The Wealth of India: A dictionary of Indian raw materials and industrial products. CSIR New Delhi.2002: IV: F-G: 35-36

  • Vogel HG (2006). Drug discovery and evaluation: Safety and Pharmacokinetic assay. -Springer-New York, pp 19-21.

  • Vonshak A, Barazani O, Sathiyamoorthy P, Shalev R, Vardy Y and Golan-Goldhirsh A (2003). Screening of south Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytother Res 17(9):1123-1125.

  • Warokar AS, Ghante MH, Duragkar NJ and Bhusari KP (2010). Anti-inflammatory and anti-oxidant activities of methanolic extract of Buchanania Lanzan Kernel. Ind J Phar Educ Res 44(4):363-368.


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  • Analgesic and Anti-inflammatory Activity of Ficus glomerata in Experimental Animal Models

Abstract Views: 73  |  PDF Views: 78

Authors

C. Menezes
Shree Devi College of Pharmacy, Kenjar, Mangalore,, India
G. Kunal
Shree Devi College of Pharmacy, Kenjar, Mangalore,, India
N. Reema
Shree Devi College of Pharmacy, Kenjar, Mangalore,, India
D. Satyanarayana
NGSM Institute of Pharmaceutical Sciences, Paneer, Mangalore,, India
K. Jagadish
Shree Devi College of Pharmacy, Kenjar, Mangalore,, India

Abstract


The anti-inflammatory and analgesic activity of various extracts of Ficus glomerata Roxb. were evaluated in experimental animals. We have determined the anti-inflammatory and analgesic activity of various extracts of the dried fruits of Ficus glomerata by oral administration at doses of 200 and 400 mg/kg of body weight to healthy animals. The extracts were studied for their anti-inflammatory activity in carageenan induced hind paw edema in rats and the paw volume wasmeasured plethysmometrically after 3 hours of injection. The extracts were also evaluated for analgesic activity using Eddy’s hot plate method in mice. The extracts of Ficus glomerata significantly reduced carageenan-induced hind paw edema in rats. The extracts showed significant analgesic activity, evidenced by increase in the reaction time by the Eddy’s hot plate method in mice. The extracts showed a similar anti-inflammatory and analgesic effect compared to standard drugs indomethacin and diclofenac sodium, respectively. The present results indicated that the ethanolic extract of Ficus glomerata exhibited significantly more activity than other extracts in reducing the pain and inflammation in experimental models.

Keywords


Ficus glomerata; anti-inflammatory; analgesic; pain; paw edema; writhing.

References