International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN)

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Analytical Characterization of a Controlled Release Polymeric Suspension of Norfloxacin


Affiliations
1 Department of Pharmaceutics, India
2 Department of Pharmaceutical Chemistry, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela - 769015, Orissa,, India
 

Qualitative analysis of a mucoadhesive polymeric (hydroxypropyl methylcellulose, HPMC) suspension of norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. The characterization of ultrasonicated formulation was performedby Fourier Transform Infrared Spectroscopy (FTIR), Raman spectroscopy, X-ray powderdiffraction (XRD) and scanning electron microscopy (SEM) analyses. For interpretation, FTIR(400-4000 cm-1 region) and Raman (140-2400 cm-1 region) spectra were used. XRD data of pure drug, polymer and the mucoadhesive polymeric suspension were obtained using a powder diffractometer, scanned from a Bragg’s angle (2θ) of 10˚ to 70˚. In addition, particle dispersion was studied using SEM techniques. The results from FTIR and Raman spectroscopic analyses of the mucoadhesive suspension suggested that carboxylic groups of norfloxacin and hydroxylgroups of HPMC undergo chemical interaction leading to esterification and hydrogen bonding. The XRD data indicated the retention of the crystalline nature of norfloxacin in the mucoadhesive suspension. Moreover, the SEM image analysis suggested that in the formulation, maximum particles exhibited network like structure to produce pseudoplastic flow. From our analysis, it may be concluded that it is feasible to prepare a homogeneous, uniformly dispersed, pharmaceutically stable controlled release norfloxacin suspension that has better bioavailability and penetration capacity.

Keywords

HPMC; FTIR; mucoadhesive suspension; norfloxacin; raman spectroscopy.
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  • Analytical Characterization of a Controlled Release Polymeric Suspension of Norfloxacin

Abstract Views: 68  |  PDF Views: 55

Authors

S. Sahoo
Department of Pharmaceutics, India
C.K. Chakraborti
Department of Pharmaceutics, India
S. Naik
Department of Pharmaceutical Chemistry, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela - 769015, Orissa,, India

Abstract


Qualitative analysis of a mucoadhesive polymeric (hydroxypropyl methylcellulose, HPMC) suspension of norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. The characterization of ultrasonicated formulation was performedby Fourier Transform Infrared Spectroscopy (FTIR), Raman spectroscopy, X-ray powderdiffraction (XRD) and scanning electron microscopy (SEM) analyses. For interpretation, FTIR(400-4000 cm-1 region) and Raman (140-2400 cm-1 region) spectra were used. XRD data of pure drug, polymer and the mucoadhesive polymeric suspension were obtained using a powder diffractometer, scanned from a Bragg’s angle (2θ) of 10˚ to 70˚. In addition, particle dispersion was studied using SEM techniques. The results from FTIR and Raman spectroscopic analyses of the mucoadhesive suspension suggested that carboxylic groups of norfloxacin and hydroxylgroups of HPMC undergo chemical interaction leading to esterification and hydrogen bonding. The XRD data indicated the retention of the crystalline nature of norfloxacin in the mucoadhesive suspension. Moreover, the SEM image analysis suggested that in the formulation, maximum particles exhibited network like structure to produce pseudoplastic flow. From our analysis, it may be concluded that it is feasible to prepare a homogeneous, uniformly dispersed, pharmaceutically stable controlled release norfloxacin suspension that has better bioavailability and penetration capacity.

Keywords


HPMC; FTIR; mucoadhesive suspension; norfloxacin; raman spectroscopy.

References