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Anti-aging: Review and Experimental Clinical Study of Bioavailable Calcium−Probiotics and their Effect on Reversing Osteopenia, Osteoporosis, and other Common and Chronic Health Conditions


Affiliations
1 President, International Media and Cultures Inc., 1250 S. Parker Rd., Ste. #203, Denver, Colorado 80231,, United States
2 Managing Director, ADFAC Labs, Pvt. Ltd., Plot No. 133, Road No. 15, Jubilee Hills, Hyderabad, A.P.,, India
 

This review highlights the innovative anti-aging strategies through effective use of calcium supplements. With the advent of pharmacology, modern medical technology and scientificadvances in food and nutrition, the longevity of human being significantly improved. However, living long or anti-aging does not make any sense unless people maintain excellent healthand quality of life. Thus, maintaining good health is the prime requirement for anti-aging. Two diseases that rob the physical fitness of the people are sarcopenia (muscle loss) andosteoporosis (loss of bone mineral density). Both of these wasting diseases can be effectively controlled with proper nutrition, life style changes, and medical supplementation. This article describes the calcium supplementation and its importance in reversing and preventing osteomalacia and osteoporosis. It particularly focuses on the bioavailable calcium and the mechanism of calcium absorption in the gastrointestinal tract (GIT). The calcium transport patterns (trans-cellular and para-cellular), sites of maximum absorption of calcium in the GIT, the role of probiotics, vitamin D and dairy peptides to improve absorption of calcium have beenbriefly discussed. It is clearly evident that not all the calcium supplements available in the market are bioavailable. The role of calcium in controlling hypertension, cholesterol, triglycerides, obesity and reduction of colon cancer has been described. The merits of administering combination regimens of bioavailable calcium and probiotics have also beenelaborated. Specific but limited clinical data has been presented demonstrating the effect of bioavailable calcium, fortified with vitamin D and probiotics with or without isoflavones, on reversing the osteopenia and controlling the osteoporosis associated symptoms. In conclusion,bioavailable calcium formulations hold promise as effective calcium supplements for better health.

Keywords

Osteopenia; osteoporosis; sarcopenia; trans-cellular; para-cellular; probiotics; isoflavones.
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  • Abrams SA and Atkinson SA (2003). Calcium, magnesium, phosphorus and vitamin D fortification of complementary foods. J Nutrition 133:2994-2999.

  • Agerback M, Gerdes LV and Richard B (1995). Hypocholesterolaemic effect of new fermented milk products in healthy middle aged men. Eur J Clin Nutrition 49:346-352.

  • Anderson JJ (1996). Calcium, phosphorous and human bone development. J Nutrition 126:1153S-1158S.

  • Avioli IV (1990). Therapy induced osteoporosis (Type III osteoporosis). In: Osteoporosis: physiological basis, assessment, and treatment, edited by HF Deluca and R Mazess, New York: Elsevier, 17.

  • Bengmark S (1998). Ecological control of the gastro intestinal tract. The role of Probiotic flora. Gut 42:2-7.

  • Bergman C, Gary-Scott D, Chen JJ and Meacham S (2009). What is next for the dietary reference intakes for bone metabolism related nutrients beyond calcium: phosphorous, magnesium, vitamin D and fluoride? Crit Rev Food Sci Nutrition 49:136-144.

  • Bierenbaum ML, Fleischamn Al and Raichelson RI (1972). Long term human studies on the lipid effects of oral calcium. Lipids 7:202-206.

  • Blake GM, Lesiecki EM, Kendler DM and Fogelman I (2007). A review of strontium renelate and its effect on DXA scans. J Clin Densitometry 10:113-119.

  • Brechner J and Armstrong WD (1941). Relation of gastric acidity to alveolar bone resorption. Proc Soc Exp Biol Med 48:98-100.

  • Bronner F (1996). Cytoplasmic transport of calcium and other inorganic ions. Comp Biochem Physiol 115:313-317.

  • Bronner F and Pansu D (1999). Nutritional aspects of calcium absorption. J Nutrition 129:9-12.

  • Camara-Martos F and Amaro-Lopez MA (2002). Influence of dietary factors on calcium bioavailability: a brief review. Biol Trace Element Res 89:43-52.

  • Code of Federal Regulations Food and Drugs (2001). Published by office of the Federal Register, Notational Archives and Records Administration, U.S. Government printing office, Washington, D.C., U.S.A.

  • Duflos C, Bellaton C, Pansu D and Bronner F (1995). Calcium solubility, intestinal sojourn time and Para cellular permeability codetermine passive calcium absorption in rats. J Nutrition 125:2348-2355.

  • Eberhardt Metzger C (2003). Cancer: out of control. Future-The Aventis magazine 1:6-10.

  • Epstein O, et al., (1982). Vitamin D, hydroxyapatite, and calcium gluconate in treatment of cortical bone thinning in postmenopausal women with primary biliary cirrhosis. Am J Nutrition 36:426-430.

  • Fuller R (1989). Probiotics in man and animals. J Appl Bacteriol 66:365-378.

  • Gaby AR (1994). Preventing and reversing osteoporosis. Prima publishing, Rocklin, California.

  • Gilliland SE, Nelson CR and Maxwell C (1985). Assimilation of Cholesterol by Lactobacillus acidophilus. Appl Environ Microbiol 49:377-381.

  • Goldin BR (1986). The Metabolism of the Intestinal Micro Flora and its relationship to dietary fat, colon and breast cancer. Prog Clin Bio Res 222:655-685.

  • Hansen M, Sandstrom B, Jensen M and Sorensen SS (1979). Effects of casein phosphopeptides on zinc and calcium absorption from bread meals. J Trace Elements Med Biol 11:143-149.

  • Hernandez-Avila M, et al., (1991). Caffeine, moderate alcohol intake, and risk of fracture of the hip and forearm in middleaged women. Am J Clin Nutrition 54:157-163.

  • Hunt JN and Johnson C (1983). Antacid induced calcium loss. Arch Internal Med 150:2037-2039.

  • Khanal RC and Nemere I (2008). Regulation of intestinal calcium transport. Ann Rev Nutrition 28:179-196.

  • Krook L et al., (1972). Human periodontal disease. Morphology and response to calcium therapy. Cornell Vet 62:32-53.

  • Madera LL (1997). The chameleon within: improving antigen delivery. Science 277:910-911.

  • Marie PJ (2006). Strontium renelate: a physiological approach for optimizing bone formation and resorption. Bone 38:10-14.

  • Marcus R (1987). Calcium intake and skeletal integrity: is there a critical relationship? J Nutrition 117:631-635.

  • Matkovic V and Heaney RP (1992). Calcium balance during human growth: evidence for threshold behavior. Am J Clin Nutrition 55:992-995.

  • McCaroon DA and Morris CD (1985). Blood pressure response to oral calcium with milk to moderate hypertension. Ann Intern Med 103:825-831.

  • McFarlan GA, and Munro A (1997). Helicobacter Pylori and gastric cancer. Bv J Surg 84:1990-199.

  • McIntosh GH (1966). Probiotic and colon cancer prevention. Asia Pacific J Clin Nutrition 5:48-52.

  • Miller JZ et al., (1988). Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents. Am J Clin Nutrition 48:1291-1294.

  • Molteni, et al., (1990). Bone Mineral density in adult celiac patients and the effect of gluten-free diet from childhood. Am J Gastroenterol 85:51-53.

  • Mora S, et al., (1993). Effect of Gluten-free diet on bone mineral content in growing patients with celiac disease. Am J Clin Nutrition 57:224-228.

  • Nagengast FM, Grubben MJAL and Van Muster IP (1995). Role of bile acids in colorectal carcinogenesis. Eur J Cancer 31A:1067- 1070.

  • Naidu AS (2009). Bio-replenishment for bone health. Bio-rep network media, Pomona, California.

  • Nicar MJ and CYC Pak (1985). Calcium Bio-availability from carbonate and calcium citrate. J Clin Endocrinol Metab 61:391- 393.

  • Nilsen KH, Jayson MIV and Dixon ASJ (1978). Microcrystalline calcium hydroxyapatite compound in corticosteroid-treated rheumatoid patients: a controlled study. Bv Med J 2:1124. Nishi Y (1996). Zinc and growth. J Am College Nutrition 15:340- 344.

  • Nordin BE, Need A and Morris H (2004). Effect of age on calcium absorption in postmenopausal women. Am J Clin Nutrition 80:998-1002.

  • Powell JJ, Jugdaohsingh R and Thompson RPH (1999). The regulation of mineral absorption in the gastrointestinal tract. Proc Nutrition Soc 58:147-153.

  • Recker RR (1985). Calcium absorption and achlorhydria. New Engl J Med 313:70-73.

  • Reddy BS (1998). Prevention of colon cancer by Pre and Probiotics. Evidence from laboratory studies. Brit J Nutrition 80:8219- 8223.

  • Reddy MS, Washam CJ, Reinbold GW and Vedamuthu ER (1973). Immunogenic properties of slime from propionibacteria. J Milk Food Technol 36:200-201.

  • Reddy MS, Reddy DRK and Prasad NAV (2000). Herbal and pharmaceutical drugs enhanced with Probiotics. U.S. patent 6,080,401:1-48.

  • Reddy MS and Reddy DRK (2004). Probiotics, biotechnology, and Ayurvedic herbs-Complementary and alternative medicine. AAPI Journal May/June issue: 32-33.

  • Reddy MS and Reddy DRK (2005). Proyurveda (Probiotic + Ayurveda) on curing the acute and chronic diseases, without any side effects-Integrated medicine program. Presented at the 23rd Annual AAPI (American Association of Physicians of Indian Origin), June 15-19, Houston, Texas, U.S.A.

  • Reddy MS and Reddy DRK (2007). Improving the health and longevity with probiotics and Ayurveda (Proyurveda™). America Bharathi (A U.S. publication of American Telugu Association). October-December issue: 16-27.

  • Reddy MS and Reddy DRK (2008). Usefulness of probiotics in complications of antibiotic overuse Clostridium difficile (C. Diff) and methicillin resistant Staphylococcus aureus (MRSA) and lactose intolerance. Presented at the 26th annual AAPI (American Association of Physicians of Indian Origin), June 26- 29, Las Vegas, Nevada, USA.

  • Reddy MS and Reddy DRK (2009). Probiotic Therapy. AAPI Journal March issue: 28-29.

  • Resnick IM, Sealey JE and Laragh JH (1983). Short and long term oral calcium alters blood pressure (BP) in essential hypertension. Fed Voc 42:300.

  • Rowland IR, Mallett AK and Wise A (1985). The effect of diet on mammalian gut flora and its metabolic activities. Crit Rev Toxicol 16:31-103.

  • Slattery ML, Sorenson AW and Ford MH (1988). Dietary calcium intake as a mitigating factor in colon caner. Am J Epidemiol 128:504-514.

  • Spencer H, et al., (1982). Effect of small doses of aluminum-containing antacids on calcium and phosphorus metabolism. Am J Clin Nutrition 36:32-40.

  • Spencer H, et al., (1985). Alcohol-osteoporosis. Am J Clin Nutrition 41:847.

  • Spencer and Kramer L (1983). Antacid-induced calcium loss. Arch Inter Med 143:657.659.

  • St-Arnaud R (2008). The direct role of vitamin-D on bone homeostasis. Arch Biochem Biophysics 473:225-230.

  • Stein WD (1992). Facilitated diffusion of calcium across the intestinal epithelial cell. J Nutrition 122:651-656.

  • Takeda E, Taketani Y and Sawada N (2004). The regulation and function of phosphate in the human body. Biofactors 21:345- 355.

  • Talmage RV and Mobley HT (2007). Calcium homeostasis: reassessment of the action of parathyroid hormone. Gen Comp Endocrinol 156:1-8.

  • Wasserman RH, Chandler JS and Meyer S.A. 1992. Intestinal calcium transport and calcium extrusion processes at the basolateral membrane. J Nutrition 122:662-671.

  • Wargovich MJ and Baer RA (1989). Basic and clinical investigations of dietary calcium in the prevention of colorectal cancer. Prev Med 18:672-679.

  • Zamel MB (2003). Symposium: Dairy product components and weight regulation; mechanism of dairy modulation of adiposity. J Nutrition 133: 252S-256S.


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  • Anti-aging: Review and Experimental Clinical Study of Bioavailable Calcium−Probiotics and their Effect on Reversing Osteopenia, Osteoporosis, and other Common and Chronic Health Conditions

Abstract Views: 72  |  PDF Views: 62

Authors

M.S. Reddy
President, International Media and Cultures Inc., 1250 S. Parker Rd., Ste. #203, Denver, Colorado 80231,, United States
D.R.K. Reddy
Managing Director, ADFAC Labs, Pvt. Ltd., Plot No. 133, Road No. 15, Jubilee Hills, Hyderabad, A.P.,, India

Abstract


This review highlights the innovative anti-aging strategies through effective use of calcium supplements. With the advent of pharmacology, modern medical technology and scientificadvances in food and nutrition, the longevity of human being significantly improved. However, living long or anti-aging does not make any sense unless people maintain excellent healthand quality of life. Thus, maintaining good health is the prime requirement for anti-aging. Two diseases that rob the physical fitness of the people are sarcopenia (muscle loss) andosteoporosis (loss of bone mineral density). Both of these wasting diseases can be effectively controlled with proper nutrition, life style changes, and medical supplementation. This article describes the calcium supplementation and its importance in reversing and preventing osteomalacia and osteoporosis. It particularly focuses on the bioavailable calcium and the mechanism of calcium absorption in the gastrointestinal tract (GIT). The calcium transport patterns (trans-cellular and para-cellular), sites of maximum absorption of calcium in the GIT, the role of probiotics, vitamin D and dairy peptides to improve absorption of calcium have beenbriefly discussed. It is clearly evident that not all the calcium supplements available in the market are bioavailable. The role of calcium in controlling hypertension, cholesterol, triglycerides, obesity and reduction of colon cancer has been described. The merits of administering combination regimens of bioavailable calcium and probiotics have also beenelaborated. Specific but limited clinical data has been presented demonstrating the effect of bioavailable calcium, fortified with vitamin D and probiotics with or without isoflavones, on reversing the osteopenia and controlling the osteoporosis associated symptoms. In conclusion,bioavailable calcium formulations hold promise as effective calcium supplements for better health.

Keywords


Osteopenia; osteoporosis; sarcopenia; trans-cellular; para-cellular; probiotics; isoflavones.

References