International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN)

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Solubility Enhancement Techniques for Poorly Water-Soluble Drugs


Affiliations
1 Department of Pharmaceutics, S.M.B.T. College of Pharmacy, Nandi Hills, Dhamangaon, Nashik, India ., India
2 S.M.B.T. Institute of D. Pharmacy, Nandi Hills, Dhamangaon, Nashik, India., India
 

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for optimum pharmacological response. Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Poor aqueous solubility is a major problem encountered with formulation development of new chemical entities. There are over 40% of new chemical entities that exhibit poor solubility and low bioavailability. As per BCS classification system, these drugs comes under BCS class II that show poor solubility and high permeability. The bioavailability of these drugs can be dramatically improved by increasing the solubility of these drugs. This review article highlights a number of techniques for enhancing the solubility of poorly water-soluble drugs.

Keywords

Solubility, BCS class II drugs, solubility enhancement, bioavailability
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  • Solubility Enhancement Techniques for Poorly Water-Soluble Drugs

Abstract Views: 70  |  PDF Views: 58

Authors

Amol S. Deshmukh
Department of Pharmaceutics, S.M.B.T. College of Pharmacy, Nandi Hills, Dhamangaon, Nashik, India ., India
Kundan J. Tiwari
S.M.B.T. Institute of D. Pharmacy, Nandi Hills, Dhamangaon, Nashik, India., India
Vijay R. Mahajan
Department of Pharmaceutics, S.M.B.T. College of Pharmacy, Nandi Hills, Dhamangaon, Nashik, India ., India

Abstract


Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for optimum pharmacological response. Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Poor aqueous solubility is a major problem encountered with formulation development of new chemical entities. There are over 40% of new chemical entities that exhibit poor solubility and low bioavailability. As per BCS classification system, these drugs comes under BCS class II that show poor solubility and high permeability. The bioavailability of these drugs can be dramatically improved by increasing the solubility of these drugs. This review article highlights a number of techniques for enhancing the solubility of poorly water-soluble drugs.

Keywords


Solubility, BCS class II drugs, solubility enhancement, bioavailability

References