International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN)

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Mechanistic Evaluation of Antinociceptive Effects of Bioactive Guided Fractions of Barleria prionitis


Affiliations
1 G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, 500028, Telangana, India ., India
2 Faculty of Pharmacy, University College of Chemical Technology, Osmania University, Hyderabad, Telangana, India ., India
 

Barleria prionitis Linn.(Acanthaceae) is a prickly shrub and traditionally whole plant is used as anti-inflammatory, expectorant, analgesic, diuretic, antirheumaticand antidiabetic. This study was conducted to investigate the antinociceptive and CNS depressant activity of ethanolic extract and the fractions of B. prionitis in mice. Ethanol extract and its fractions were tested at a dose of 200 and 400 mg/kg. Ethanol, petroleum ether and chloroform fractions demonstrated significant antinociceptive activity at 400 mg/kg and significantly increased the latency in hot plate test and the action was antagonised by naloxone, indicating a potential opioid-like mechanism. In conclusion, the ethanol, pet ether and chloroform fractions of B. prionitis markedly demonstrated the antinociceptive action. The CNS depressant and good protective effect on pain stimuli suggest that the possible mechanisms appear to be due to involvement of opioid and/or peripheral receptors.

Keywords

Antinociceptive activity; analgesia; morphine; naloxone; Barleria prionitis.
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  • Mechanistic Evaluation of Antinociceptive Effects of Bioactive Guided Fractions of Barleria prionitis

Abstract Views: 69  |  PDF Views: 63

Authors

Azmathunnisa Begum
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, 500028, Telangana, India ., India
Sama Venkatesh
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, 500028, Telangana, India ., India
Rajesh Bolleddu
Faculty of Pharmacy, University College of Chemical Technology, Osmania University, Hyderabad, Telangana, India ., India
Ravi Alvala
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, 500028, Telangana, India ., India
D. Jaya Prakash
Faculty of Pharmacy, University College of Chemical Technology, Osmania University, Hyderabad, Telangana, India ., India

Abstract


Barleria prionitis Linn.(Acanthaceae) is a prickly shrub and traditionally whole plant is used as anti-inflammatory, expectorant, analgesic, diuretic, antirheumaticand antidiabetic. This study was conducted to investigate the antinociceptive and CNS depressant activity of ethanolic extract and the fractions of B. prionitis in mice. Ethanol extract and its fractions were tested at a dose of 200 and 400 mg/kg. Ethanol, petroleum ether and chloroform fractions demonstrated significant antinociceptive activity at 400 mg/kg and significantly increased the latency in hot plate test and the action was antagonised by naloxone, indicating a potential opioid-like mechanism. In conclusion, the ethanol, pet ether and chloroform fractions of B. prionitis markedly demonstrated the antinociceptive action. The CNS depressant and good protective effect on pain stimuli suggest that the possible mechanisms appear to be due to involvement of opioid and/or peripheral receptors.

Keywords


Antinociceptive activity; analgesia; morphine; naloxone; Barleria prionitis.

References