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Therapeutics of Bioactive Compounds from Medicinal Plants and Honeybee Products against Cancer


Affiliations
1 Department of Biosciences (UIBT), Chandigarh University, Mohali 140 413, India
2 Department of Botany, Panjab University, Chandigarh 160 014, India
 

Every year, more than 12 million people are diagnosed with cancer worldwide. Cancer diagnosis is difficult for anybody to bear, and dealing with treatment is sometimes more complicated than the disease itself. When it comes to cancer treatment choices, chemotherapy is the most well-known since it is frequently used and recommended by specialists all over the world. On the other hand, chemotherapy is recognized for destroying healthy cells, and this destruction led to several negative impacts on the body. Recent advancements in biology have allowed scientists to better study the possible use of other methods, including phytotherapy and apitherapy for treating or managing many malignant conditions. Phytotherapy and apitherapy are among the best alternatives to chemotherapy as plants and honeybee products are chief sources of phytochemicals with anticancer properties. For example, hesperidin, melittin, apamin, artepillin, 10-hydroxy-2-decenoic acid (10-HDA), Major Royal Jelly Proteins (MRJP), jelleins, royalisin and caffeic acid phenethyl ester are important plant and bee engineered product constituents which by inducing apoptosis and arresting cell cycle control the proliferation of cancer cells. In general, this review highlights problems related to cancer treatment using chemicals. It discusses phytotherapy and apitherapy as an alternative to chemotherapy, while plants and bee products rich in natural anticancer compounds have greater potency to treat cancer.

Keywords

Apitherapy, Bee engineered products, Chemotherapy, Phytochemicals, Phytotherapy, Side effects.
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  • DeVita VT Jr & Chu E, A history of cancer chemotherapy, Cancer Res, 68 (2008): 8643‒8653, https://doi: 10.1158/0008-5472.CAN-07-6611.
  • Altun I & Sonkaya A, The most common side effects experienced by patients were receiving first cycle of chemotherapy, Iran J Public Health, 47 (2018) 1218‒1219.
  • Kumar P V, Vishwabhan S & Vishal S, A review on recent approaches for cancer treatment, J Pharm Res, 5 (2012) 274‒276.
  • Munstedt K & Mannle H, Bee products and their role in cancer prevention and treatment, Complement Ther Med, 51 (2020) 102390, https://doi.org/10.1016/j.ctim.2020.102390.
  • Tamura K, Saito H, Asakura H, Kohji O, Jun T, Toru H & Nobu A, Recombinant human soluble thrombomodium to treat disseminated intravascular coagulation in solid tumors: results of a one arm prospective trial, Int J Clin Oncol, 20 (2015) 821‒828.
  • Campos J F, dos Santos U P, Macorini F B, Felipe de Melo A M M, Balestieri J B P, Paredes-Gamero E J, Cardoso C A L, de Picoli Souza K & dos Santos E L, Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae), Food Chem Toxicol, 65 (2014) 374‒380.
  • Al-Amri A, Alzahrani R S, Alhajri K, Alqarzea S M, Alzahrani F & Alturky S, Complementary and alternative medicine among cancer patients and its complications: local experience, IJMDC, 5 (2021) 2103‒2107, doi:10.24911/IJMDC.51-1634153885.
  • Badolato M, Carullo G, Cione E, Aiello F & Caroleo M C, From the hive: Honey, a novel weapon against cancer, Eur J Med Chem, 142 (2017) 290‒299.
  • Ahmad F, Seerangan P, Mustafa M Z, Osman Z F, Abdullah J M & Zamzuri I, Anti-cancer properties of Heterotrigona itama sp. honey via induction of apoptosis in malignant glioma cells, Mal J Med Sci, 26 (2019) 30‒39.
  • Amjad M T, Chidharla A & Kasi A, Cancer chemotherapy, [Updated 2022 Mar 3], in StatPearls [Internet], Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK564367/
  • Rahman & Mahbub, Metabolic pathways and chemotherapy drugs, 2016, 10.2174/9781681081656116070003.
  • Arslan F T, Basbakkal Z & Kantar M, Quality of life and chemotherapy-related symptoms of Turkish cancer children undergoing chemotherapy, Asian Pac J Cancer Prev, 14 (2013) 1761‒1768.
  • Partridge A H, Burstein H J, Winer E P, Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer, J Natl Cancer Inst Monogr, 30 (2001) 135‒142.
  • Schnell F M, Chemotherapy-induced nausea and vomiting: The importance of acute antiemetic control, Oncologist 8 (2003) 187‒198.
  • Farrell C, Brearley S G, Pilling M & Molassiotis A, The impact of chemotherapy-related nausea on patients’ nutritional status, psychological distress and quality of life, Support Care Cancer, 21 (2013) 59‒66.
  • Moradian S & Howell D, Prevention and management of chemotherapy-induced nausea and vomiting, Int J Palliat Nurs, 21 (2015) 216‒218.
  • Haidinger R & Bauerfeind I, Long-term side effects of adjuvant therapy in primary breast cancer patients: results of a web-based survey, Breast Care (Basel), 14 (2019) 111‒116.
  • Schirrmacher V, From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment, Intl J Oncol, 54 (2019) 407‒419.
  • Liu Y Q, Wang X L, He D H & Cheng Y X, Protection against chemotherapy and radiotherapy induced side effects: A review based on the mechanisms and therapeutic opportunities of phytochemical, Phytomed, 80 (2021) 153402.
  • Lin S R, Chang C H, Hsu C F, Tsai M J, Cheng H, Leong M K & Ping-Jyun S, Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence, Br J Pharmacol, 177 (2020) 1409‒1423.
  • Barlow J, Wright C, Sheasby J, Turner A & Hainsworth J, Self-management approaches for people with chronic conditions: A review, Patient Edu Counsel, 48 (2002) 177‒187.
  • Godfrey C, Harrison M B, Lysaght R, Lamb M, Graham I D & Oakley P, Care of self–care by other–care of other: The meaning of self-care from research, practice, policy and industry perspectives, Int J Evid Based Healthc, 9 (2011) 3‒4.
  • Aranda S, Jefford M, Yates P, Gough K, Seymour J, Francis P, Baravelli C, Breen S & Schofield P, Impact of a novel nurseled prechemotherapy education intervention (ChemoEd) on patient distress, symptom burden, and treatment-related information and support needs: Results from a randomised, controlled trial, Ann Oncol, 23 (2012) 222‒231.
  • Haghpanah S, Amini M, Kherad M & Sadeghimehr R, Knowledge and practice of patients with breast cancer about complication of chemotherapy, J Res Health Sci, 6 (2006) 28‒32.
  • Saraswat N, Chopra A, Sood A, Kamboj P & Kumar S, A descriptive study to analyze chemotherapy-induced hair loss and its psychosocial impact in adults: our experience from a tertiary care hospital, Indian Dermatol Online J, 10 (2019) 426‒430.
  • Rosman S, Cancer and stigma: Experience of patients with chemotherapy-induced alopecia, Patient Educ Couns, 52 (2004) 333‒339.
  • Williams J, Woods C & Cunningham-Warburton P A narrative study of chemotherapy-induced alopecia, Oncol Nurs Forum, 26 (1999) 1463‒1468.
  • Arunachalam S S, Shetty A P, Panniyadi N, Meena C, Kumari J, Rani B, Das P & Kumari S, Study on knowledge of chemotherapy’s adverse effects and their self-care ability to manage - the cancer survivor’s impact, Clin Epidemiol Glob Health, 11 (2021) 100765.
  • Protiere C, Evans K & Camerlo J, Efficacy and tolerance of a scalp-cooling system for prevention of hair loss and experience of breast cancer patients treated by adjuvant chemotherapy, Support Care Cancer, 10 (2002) 529‒537.
  • Bajracharya N, Karki P, Sapkota S, Bastakoti S, Yagol N, Khan G M, Shakya R & Rao B S, Prevalence pattern of cancer and handling of cytotoxic drugs, Kathmandu University, J Sci Eng Technol, 2 (2006) 1‒7.
  • Athavale A, Athavale T & Roberts D M, Antiemetic drugs: What to prescribe and when, Aust Prescr, 43 (2020) 49‒56.
  • Mock V, Atkinson A, Barsevick A, Cella D, Cimprich B, Cleeland C, Donnelly J, Eisenberger M A, Escalante C, Hinds P, Jacobsen P B, Kaldor P, Knight S J, Peterman A, Piper B F, Rugo H, Sabbatini P & Stahl C, Cancer-related fatigue clinical practice guidelines in oncology, J Natl Comp Cancer Network, 1 (2003) 308‒331.
  • Littlewood T J, Bajetta E, Nortier J W R, Vercammen E & Rapoport B, Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, doubleblind, placebo-controlled trial, J Clin Oncol, 19 (2001) 2865‒2874.
  • Gabrilove J L, Cleeland C S, Livingston R B, Sarokham B, Winer E & Einhorn L, Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: Improvements in hemoglobin and quality of life are similar to three-times weekly dosing, J Clin Oncol 19 (2001) 2875‒2882.
  • Wickham R J, Managing constipation in adults with cancer, J Adv Pract Oncol, 8 (2017) 149‒161. 36 Helen H P & Jun B J, A comparison of sennosides-based bowel protocols with and without docusate in hospitalized patients with cancer, J Palliat Med, 11 (2008) 575‒581.
  • Rodriguez-Wallberg K A & Oktay K, Options on fertility preservation in female cancer patients, Cancer Treat Rev, 38 (2012) 354‒361.
  • Zeltzer L K, Cancer in adolescents and young adults psychosocial aspects, Long-term survivors, Cancer, 71 (1993) 3463‒3468.
  • Wu H & Pang Q, The effect of vitamin D and calcium supplementation on falls in older adults: a systematic review and meta-analysis, Orthopade, 46 (2017) 729‒736.
  • Dawson-Hughes B, Vitamin D and muscle function, J Steroid Biochem Mol Biol, 173 (2017) 313‒316.
  • Dhaliwal R & Aloia J F, Effect of vitamin D on falls and physical performance. Endocrinol, Metab, Clin North Am, 46 (2017) 919‒933.
  • Dent S F, Kikuchi R, Kondapalli L, Khan R I, Brezden- Masley C, Barac A & Fradley M, Optimizing cardiovascular health in patients with cancer: A practical review of risk assessment, monitoring, and prevention of cancer treatmentrelated cardiovascular toxicity, Am Soc Clin Oncol Educ Book, 40 (2020) 501‒515.
  • Rock C L, Doyle C, Demark-Wahnefried W, Meyerhardt J, Courneya K S, Schwarrtz A L, Bandera E V, Hamilton K K, Grant B, McCullough M, Byers T & Gansler T, Nutrition and physical activity guidelines for cancer survivors, CA Cancer J Clin, 62 (2012) 243‒274.
  • Chlebowski R T, Aiello E & McTiernan A, Weight loss in breast cancer patient management, J Clin Oncol, 20 (2002) 1128‒1143.
  • Kroenke C H, Fung T T, Hu F B & Holmes M D, Dietary patterns and survival after breast cancer diagnosis, J Clin Oncol, 23 (2002) 9295‒9303.
  • Kwan M L, Weltzien E, Kushi L H, Castillo A, Slattery M L & Caan B J, Dietary patterns and breast cancer recurrence and survival among women with early-stage breast cancer, J Clin Oncol, 27 (2009) 919‒926.
  • Charles J, Chaperot L, Hannani D, Costa J B, Templier I, Trabelsi S, Gil H, Moisan A, Persoons V, Hegelhofer H, Schir E, Quesada J L, Mendoza C, Aspord C, Manches O, Coulie P G, Khammari A, Dreno B, Leccia M T & Plumas J, An innovative plasmacytoid dendritic cell line-based cancer vaccine primes and expands antitumor T-cells in melanoma patients in a first-in-human trial, Oncoimmunology, 9(1) (2020) 1738812, doi:10.1080/2162402X.2020.1738812.
  • Parasramka M A & Gupta S V, Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells, J Oncol, (2012) 709739. 49 Ma H, Carpenter CL, Sullivan-Halley J & Bernstein L, The roles of herbal remedies in survival and quality of life among long-term breast cancer survivors - results of a prospective study, BMC Cancer, 11 (2011) 222.
  • McLay J S, Stewart D, George J, Rore C & Heys S D, Complementary and alternative medicines use by Scottish women with breast cancer, What, why and the potential for drug interactions?, Eur J Clin Pharmacol, 68 (2012) 811– 819.
  • Yan Z, Wang H, Liu L, Guohua D U, Chen R, Study on in vitro anti-tumor activity of triterpenoids from Ganoderma lucidum, Int J Lab Med, 38 (2017) 633–634.
  • Pink J J, Wuerzberger-Davis S, Tagliarino C, Planchon S M, Yang X, Froelich C J & Booth D A, Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during β- lapachone-mediated apoptosis, Exp Cell Res, 255 (2000) 144–155.
  • Liu M H, Ko C H, Ma N, Tan P W, Fu W M & He J Y, Chemical profiles, antioxidant and anti-obesity effects of extract of Bambusa textilis McClure leaves, J Funct Foods, 22 (2016) 533–546.
  • Abu-Dahab R, Afifi F, Kasabri V, Majdalawi L & Naffa R, Comparison of the antiproliferative activity of crude ethanol extracts of nine salvia species grown in Jordan against breast cancer cell line models, Pharmacogn Mag, 8 (2012) 319–324.
  • Huang P H, Huang C Y & Chen M C, Emodin and Aloe- Emodin suppress breast cancer cell proliferation through ER α Inhibition, Evid-Based Complement Altern Med, (2013) 376123.
  • Mandal S & Stoner G D, Inhibition of Nnitrosobenzylmethylamine- induced esophageal tumorigenesis in rats by ellagic acid, Carcinogenesis, 11 (1990) 55–61.
  • Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F & Pizza C, The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line, Anticancer Res, 21 (2001) 2457–2461.
  • Shirode A B, Bharali D J, Nallanthighal S, Coon J K, Mousa S A & Reliene R, Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention, Int J Nanomedicine, 10 (2015) 475.
  • Ghasemzadeh, A, Jaafar H Z, Rahmat A, Devarajan T, Evaluation of bioactive compounds, pharmaceutical quality, and anticancer activity of curry leaf (Murraya koenigii L.), Evid-based Complement Altern Med (2014) 1–8.
  • Mgbeahuruike E E, Yrjonen T, Vuorela H & Holm Y, Bioactive compounds from medicinal plants: Focus on Piper species, S Afr J Bot, 112 (2017) 54‒69.
  • Wargovich M J, Anticancer properties of fruits and vagatables, Hortic Sci, 35 (2000) 573–574.
  • Lu J N, Panchanathan R, Lee W S, Kim H J, Kim D H, Choi Y H, Anthocyanins from the fruit of Vitis coignetiae Pulliat inhibit TNF-augmented cancer proliferation, migration, and invasion in A549 cells, Asian Pac J Cancer Prev, 18(11) (2017) 2919–2923.
  • Liu Y, Zhu P, Wang Y, Wei Z, Tao L, Zhu Z, Sheng X, Wang S, Ruan J, Liu, Z. Cao Y, Shan Y, Sun L, Wang A, Chen W & Lu Y, Antimetastatic therapies of the polysulfide diallyl trisulfide against triple-negative breast cancer (TNBC) via suppressing MMP2/9 by blocking NF-κB and ERK/MAPK signaling pathways, PLOS ONE, 10 (2015) e0123781.
  • Wu C H, Ho Y S, Tsai C Y, In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter, Int J Cancer, 124 (2009) 2210‒2219.
  • Eswaraiah G, Peele K A, Krupanidhi S, Kumar R B & Venkateswarulu T C, Identification of bioactive compounds in leaf extract of Avicennia alba by GC-MS analysis and evaluation of its in-vitro anticancer potential against MCF7 and HeLa cell lines, J King Saud Univ Sci, 32 (2020) 740‒744.
  • Castro-Puyana M, Pérez-Sánchez A & Valdes A, Pressurized liquid extraction of Neochloris oleoabundans for the recovery of bioactive carotenoids with anti-proliferative activity against human colon cancer cells, Food Res Int, 99 (2017) 1048‒1055.
  • Lee J, Cho K, Flaxseed sprouts induce apoptosis and inhibit growth in MCF-7 and MDA-MB-231 human breast cancer cells, In Vitro Cell Dev Biol Anim, 48 (2012) 244–250. 68 Seki T, Hosono T & Hosono-Fukao T, Anticancer effects of diallyl trisulfide derived from garlic, Asia Pac J Clin Nutr, 17 (2008) 249‒252.
  • Jia L, Jin H, Zhou J, Chen L, Lu Y, Ming Y, Yu Y, A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways, BMC Complement Altern Med, 13 (2013) 1-1.
  • Thangapazham R L, Passi N & Maheshwari R K, Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cells, Cancer Biol Ther, 6 (2007) 1938–1943.
  • Nadaf S J & Killedar S G, Curcumin nanocochleates: Use of design of experiments, solid state characterization, in vitro apoptosis and cytotoxicity against breast cancer MCF-7 cells, J Drug Deliv Sci Technol, 47 (2018) 337–350.
  • Lee Y R, Chen M & Lee J D, Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway, Science, 364 (2019) 6441.
  • Wong S, Che C M & Leung K W, Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview, Nat Prod Rep, 32 (2015) 256–272.
  • Kuttan R, Bhanumathy P, Nirmala K & George M C, Possible anticancer activity of turmeric, Cancer Lett, 29 (1985) 197–202.
  • Rwigemera A, Mamelona J, Martin L J, Comparative effects between fucoxanthinol and its precursor fucoxanthin on viability and apoptosis of breast cancer cell lines MCF-7 and MDA-MB-231, Anticancer Res, 35 (2015) 207–219.
  • Jayaprakasha G K, Mandadi K K, Poulose S M, Jadegoud Y, Gowda G N, Patil B S, Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf., Bioorg Med Chem, 15 (2007) 4923‒4932.
  • Patel B, Das S, Prakash R & Mohammad Y, Natural bioactive compound with anticancer potential, Int J Chem Pharm Sci, 1 (2010) 32‒41.
  • Lin Y, Collier A C, Liu W, Berry M J & Panee J, The inhibitory effect of bamboo extract on the development of 7, 12-dimethylbenz [a] anthracene (DMBA)-induced breast cancer, Phytother Res, 22 (2008) 1440‒1445.
  • Pryme F, Bardocz S, Pusztai A & Ewen S W B, Suppression of growth of tumour cell lines in vitro and tumours in vivo by mistletoe lectins, Histol Histopathol, 21 (2006) 285–299.
  • Record I R & Dreosti I E, Protection by tea against UV-A + B-induced skin cancers in hairless mice, Nutr Cancer, 32 (1998) 71–75.
  • Qi W, Weber C R, Wasland K, Savkovic S D, Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity, BMC Cancer, 11 (2011) 1‒9.
  • Efferth T, Saeed M E M, Mirghani E, Alim A, Yassin Z, Saeed E, Khalid H E & Daak S, Integration of phytochemicals and phytotherapy into cancer precision medicine, Oncotarget, 8 (2017) 50284–50304, doi: 10.18632/oncotarget.17466.
  • Woll S, Kim S H & Efferth T, Animal plant warfare and secondary metabolite evolution, Nat Prod Bioprospect, 3 (2013) 1‒7.
  • Liu R H, Potential synergy of phytochemicals in cancer prevention: Mechanism of action, J Nutr, 134 (2004): 3479S‒3485S.
  • Donaldson M S, Nutrition and cancer: A review of the evidence for an anti-cancer diet, Nutr J, 3 (2004) 3‒19.
  • Sengupta A, Ghosh S, Bhattacharjee S & Das S, Indian food ingredients and cancer prevention - an experimental evaluation of anticarcinogenic effects of garlic in rat colon, Asian Pac J Cancer Prev, 5 (2004) 126‒132.
  • Prakash O, Kumar A, Kumar P & Ajeet P, Anticancer potential of plants and natural products: A review, Am J Pharm Sci, 1 (2013) 104‒115, doi: 10.12691/ajps-1-6-1.
  • Şengü I F & Vatansev H, Overview of apitherapy products: Anti-cancer effects of bee venom used in apitherapy, Int J Tradit Complement Med Res, 2 (2021) 36‒48.
  • Pasupuleti V R, Sammugam L, Ramesh N & Gan S H, Honey, propolis and royal jelly: a comprehensive review of their biological actions and health benefits, Oxid Med Cell Longev, (2017) 1259510, doi: 10.1155/2017/1259510
  • Zheng Y, Electrochemical determination of antioxidant activity of different bee products, Int J Electrochem Sci, 14 (2019) 3663‒3672, doi: 10.20964/2019.04.09.
  • Luo X, Dong Y, Gu C, Zhang X & Ma H, Processing technologies for bee products: An overview of recent developments and perspectives, Front Nutr, 8 (2021) 727181.
  • Rana A & Parmar A S, Re-exploring silver nanoparticles and its potential applications, Nanotechnol Environ Eng, 2022 (2022), https://doi.org/10.1007/s41204-022-00301-w.
  • Premratanachai P & Chanchao C, Review of the anticancer activities of bee products, Asian Pac J Trop Biomed, 4 (2014) 337‒344.
  • Wehbe R, Frangieh J, Rima M, Obeid D El, Sabatier J M & Fajloun Z, Bee venom: Overview of main compounds and bioactivities for therapeutic interests, Molecules, 24 (2014) 2997.
  • Kwon N Y, Sung S H, Sung H K & Park J K, Anticancer activity of bee venom components against breast cancer, Toxins (Basel), 14 (2022) 460.
  • Rady I, Siddiqui I A, Rady M & Mukhtar H, Melittin a major peptide component of bee venom, and its conjugates in cancer therapy, Cancer Lett, 402 (2017) 16‒31.
  • Gajski G & Garaj-Vrhovac V, Melittin: A lytic peptide with anticancer properties, Environ Toxicol Pharm, 36 (2017) 697‒705.
  • Zheng J, Lee H L & Ham Y W, Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B, Oncotarget, 6 (2015) 44437‒44451.
  • Duffy C, Sorolla A, Wang E, Golden E & Woodward E, Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer, Precis Oncol, 4 (2020) 24.
  • Kim D H, Lee H W & Park H W, Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner, BMB Rep, 53 (2020) 419‒424.
  • Zhao J, Hu W, Zhang Z, Zhou Z & Duan J, Bee venom protects against pancreatic cancer via inducing cell cycle arrest and apoptosis with suppression of cell migration, J Gastrointest Oncol, 2 (2022) 847‒858.
  • Pavel C I, Mărghitaş L A, Bobiş O, Dezmirean D S & Şapcaliu A, Biological activities of royal jelly-review, J Anim Sci Biotechnol, 44 (2011) 108‒118.
  • Ahmad S, Campos M G, Fratini F, Altaye S Z & Li J , New insights into the biological and pharmaceutical properties of royal jelly, Int J Mol Sci, 21 (2020) 382‒389.
  • Miyata Y & Sakai H Anti-Cancer and protective effects of royal jelly for therapy-induced toxicities in malignancies, Int J Mol Sci, 19 (2018) 3270.
  • Al-Kahtani S & Taha E K A, Effect of harvest time on royal jelly yield and chemical composition, J Kansas Entomol Soc, 93 (2020) 132‒139.
  • Li S, Tao L, Yu X, Zheng H & Wu J, Royal jelly proteins and their derived peptides: Preparation, properties, and biological activities, J Agric Food Chem, 69 (2021) 14415‒14427.
  • Kimura Y, Antitumor and antimetastatic actions of various natural products, Stud Nat Prod Chem, 34 (2008) 35‒76.
  • Miyata Y, Ohba K, Matsuo T, Mitsunari K & Sakai H, A randomized, double-blinded clinical trial of royal jelly intake for anticancer effects and suppressing adverse events in renal cell carcinoma patients treated with tyrosine kinase inhibitors, J Clin Oncol, 38 (2020) 697.
  • Sobral F, Sampaio A, Falcão S, João M & Queiroz R P, Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal Filipa, Food Chem Toxicol, 94 (2016) 172–177.
  • Salama S, Shou Q, Abd El-Wahed A A, Elias N & Xiao J, Royal jelly: Beneficial Properties and synergistic effects with chemotherapeutic drugs with particular emphasis in anticancer strategies, Nutrients, 14 (2022) 4166.
  • Saralaya S, Jayanth B S, Thomas N S & Sunil S M, Bee wax and honey-a primer for OMFS, Oral Maxillofac Surg, 25 (2022) 1–6.
  • Fratini F, Cilia G, Turchi B & Felicioli A, Beeswax: A minireview of its antimicrobial activity and its application in medicine, Asian Pac J Trop Med, 9 (2016) 839‒843.
  • Nainu F, Masyita A, Bahar M A, Raihan M, Prova S R, Mitra S, Emran T B & Simal-Gandara J, Pharmaceutical prospects of bee products: special focus on anticancer, antibacterial, antiviral and antiparasitic properties, Antibiotics, 10 (2021) 822.
  • Hashem N M, Hassanein E M & Simal-Gandara J, Improving reproductive performance and health of mammals using honeybee products, Antioxidants, 10 (2021) 336.
  • Teixeira E W, Negri G, Meira R M, Message D & Salatino A, Plant origin of green propolis: Bee behavior, plant anatomy and chemistry, Evid Based Complement Alternat Med, 2 (2005) 85‒92, doi:10.1093/ecam/neh055.
  • Silva-Carvalho R, Baltazar F & Almeida-Aguiar C, Propolis: A complex natural product with a plethora of biological activities that can be explored for drug development, Evid Based Complement Alternat Med, 3 (2015) 29.
  • Simone-Finstrom M & Spivak M, Propolis and bee health: The natural history and significance of resin use by honey bees, Apidologie, 41 (2010) 295‒311.
  • Campos J F, Dos Santos H F, Bonamigo T, de Campos Domingues N L, de Picoli Souza K & Dos Santos E L, stingless bee propolis: New insights for anticancer drugs, Oxid Med Cell Longev, (2021) 2169017, doi:10.1155/2021/2169017.
  • Torres A R, Sandjo L P, Friedemann M T, Tomazzoli M M, Maraschin M, Mello C F & Santos A R S, Chemical characterization, antioxidant and antimicrobial activity of propolis obtained from Melipona quadrifasciata and Tetragonisca angustula stingless bees. Braz J Med Biol Res, 51 (2018) 7118‒7210.
  • Cisilotto J, Sandjo L P, Faqueti L G, Fernandes H, Joppi D, Biavatti M W & Creczynski-Pasa T B, Cytotoxicity mechanisms in melanoma cells and UPLC-QTOF/MS2 chemical characterization of two Brazilian stingless bee propolis: uncommon presence of piperidinic alkaloids, J Pharm Bio med Anal, 149 (2018) 502‒511.
  • Desamero M J, Kakuta S, Tang Y, Chambers J K, Uchida K, Estacio M A, Cervancia C, Kominami Y, Ushio H, Nakayama J, Nakayama H & Kyuwa S, Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma, Sci Rep, 9 (2019) 19635, doi:10.1038/ s41598-019-55465-4.
  • Hueso-Falcón I, Girón N, Velasco P, Amaro-Luis J M, Ravelo A G, de las Heras B & Hortelano S, Estevez-Braun, Synthesis and induction of apoptosis signaling pathway of ent-kaurane derivatives, Bioorg Med Chem, 18 (2010) 1724‒1735, doi: 10.1016/j.bmc.2009.11.064.
  • Souto E B, Zielinska A, Souto S B, Durazzo A, Lucarini M, Santini A, Silva A M, Atanasov A G, Marques C, Andrade L N & Severino P, (+)-Limonene 1,2-Epoxide- Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line, Int J Mol Sci, 21 (2020) 1449, doi: 10.3390/ijms21041449.
  • Umthong S, Phuwapraisirisan P, Puthong S & Chanchao C, In vitro antiproliferative activity of partially purified Trigona laeviceps propolis from Thailand on human cancer cell lines, BMC Complement Altern Med, 1 (2011) 1‒8.
  • Kustiawan P M, Phuwapraisirisan P, Puthong S, Palaga T, Arung E T & Chanchao C Propolis from the stingless bee Trigona incisa from East Kalimantan, Indonesia, induces In Vitro cytotoxicity and apoptosis in cancer cell lines, Asian Pac J Cancer Prev, 16 (2015) 6581‒6589, doi:10.7314/apjcp.2015.16.15.6581.
  • Chiu H F, Han Y C, Shen Y C, Golovinskaia O, Venkatakrishnan K & Wang C K, Chemopreventive and chemotherapeutic effect of propolis and its constituents: A mini-review, J Cancer Prev, 25 (2020) 70‒78, doi: 10.15430/JCP.2020.25.2.70.
  • Doğan H, Silici S & Ozcimen A A, Biological effects of propolis on cancer, Turk J of Food and Agri Sci, 8 (2020) 573‒579.
  • Rana A, Antibacterial, antifungal and antihelminthic properties of ethanolic, methanolic and water extracts of pollen, J Pharm Res Int, 33 (2021) 78‒88, doi.org/10.9734/ jpri/2021/v33i53B33682.
  • Rana A & Kumar N R, Antioxidative potential of propolis on Staphylococcus aureus infected BALB/c mice: A biochemical study, Indian J Biochem Biophys, 59 (2022) 1006‒1015.
  • Rana A, Kumar N R & Kaur J, Therapeutic effect of propolis on Staphylococcus aureus induced oxidative stress in kidney of BALB/c mice: a biochemical and histopathological study, Indian J Exp Biol, 60 (2022a) 597‒606
  • Rana A, Kumar N R & Kaur J, Therapeutic effect of propolis on Staphylococcus aureus induced oxidative stress in spleen of BALB/c mice: A biochemical and histopathological study, Indian J Nat Prod Resour, 13 (2022b) 1‒13.
  • Orrenius S, Gogvadze V & Zhivotovsky B, Calcium and mitochondria in the regulation of cell death, Biochem Biophy Res Comm, 460 (2015) 72‒81.
  • D’arcy M S, Cell death: A review of the major forms of apoptosis, necrosis and autophagy,” Cell Biol Intl, 43 (2019) 582‒592.
  • Sepúlveda C, Núñez O, Torres A, Guzmán L & Wehinger S, Antitumor activity of propolis: Recent advances in cellular perspectives, animal models and possible applications, Food Rev Intl, 36 (2020) 429‒455.
  • Berghe T V, Linkermann A, Jouan-Lanhouet S, Walczak H & Vandenabeele P, Regulated necrosis: The expanding network of non-apoptotic cell death pathways, Nature Rev Mol Cell Biol, 15 (2014) 135‒147.
  • Pasparakis M & Vandenabeele P, Necroptosis and its role in inflammation, Nature, 517 (2015) 311‒320.
  • Czabotar P E, Lessene G, Strasser A & Adams J M, Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy, Nat Rev Mol Cell Biol, 15 (2014) 49‒63.
  • Rana & Kumar, Antioxidative potential of pollen, propolis and bee bread against damage caused by Staphylococcus aureus in liver and kidney of BALB/c mice: A biochemical study, J Sci Ind Res, 82 (2023) 652‒660.
  • Thakur M & Nanda V, Composition and functionality of bee pollen: A review, Trends Food Sci Technol, 98 (2020) 82‒106.
  • Gardana C, Del Bo C, Quicazán M C, Corrrea A R & Simonetti P, Nutrients, phytochemicals and botanical origin of commercial bee pollen from different geographical areas, J Food Compos Ana, 73 (2018) 29‒38.
  • Abdelnour S A, Abd El-Hack M E, Alagawany M, Farag M R & Elnesr S S, Beneficial impacts of bee pollen in animal production, reproduction and health, J Anim Physiol Anim Nutr, 103 (2019) 477‒484.
  • Sattler J A G, de Melo I L P, Granato D, Araújo E, da Silva de Freitas A, Barth O M, Sattler A & de Almeida-Muradian L B, Impact of origin on bioactive compounds and nutritional composition of bee pollen from southern Brazil: A screening study, Food Res Int, 77 (2015) 82‒91.
  • Sattler J A G, De-Melo A A M, Nascimento K S D, Melo I L P D, Mancini-Filho J, Sattler A & Almeida-Muradian L B D, Essential minerals and inorganic contaminants (barium, cadmium, lithium, lead and vanadium) in dried bee pollen produced in Rio Grande do Sul State, Brazil, Food Sci Technol, 36 (2016) 505‒509.
  • Nassar A M K, Salim Y M M, Eid K S A, Shaheen H M, Saati A A, Hetta H F, Elmistekawy A & Batiha G E, Ameliorative effects of honey, propolis, pollen, and royal jelly mixture against chronic toxicity of sumithion insecticide in white albino rats, Molecules, 25 (2016) 2633, doi:10.3390/molecules25112633.
  • Komosinska-Vassev K, Olczyk P, Kaźmierczak J, Mencner L & Olczyk K, Bee pollen: Chemical composition and therapeutic application, Evid Based Complement Altern Med, 3 (2015) 297425.
  • Kostić A Ž, Milinčić D D, Gašić U M, Nedić N & Stanojević S P, Polyphenolic profile and antioxidant properties of beecollected pollen from sunflower (Helianthus annuus L.) plant, LWT, 112 (2019) 108244.
  • Aw Yong P Y, Islam F, Harith H H, Israf D A, Tan J W & Tham C L, The Potential use of honey as a remedy for allergic diseases: A mini review, Front Pharmacol, 11 (2021) 599080, doi:10.3389/fphar.2020.599080.
  • Santos-Buelga C & González-Paramás A M, Chemical composition of honey, in Bee Products-Chemical and Biological Properties edited by J M Alvarez-Suarez (Springer International Publishing: Cham, Switzerland) 4 (2021) 43‒82.
  • Samarghandian S, Farkhondeh T & Samini F, Honey and health: A review of recent clinical research, Pharmacogn Res, 9 (2017) 121‒127.

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  • Therapeutics of Bioactive Compounds from Medicinal Plants and Honeybee Products against Cancer

Abstract Views: 19  |  PDF Views: 17

Authors

Anita Rana
Department of Biosciences (UIBT), Chandigarh University, Mohali 140 413, India
Harjit Kaur Bajwa
Department of Botany, Panjab University, Chandigarh 160 014, India

Abstract


Every year, more than 12 million people are diagnosed with cancer worldwide. Cancer diagnosis is difficult for anybody to bear, and dealing with treatment is sometimes more complicated than the disease itself. When it comes to cancer treatment choices, chemotherapy is the most well-known since it is frequently used and recommended by specialists all over the world. On the other hand, chemotherapy is recognized for destroying healthy cells, and this destruction led to several negative impacts on the body. Recent advancements in biology have allowed scientists to better study the possible use of other methods, including phytotherapy and apitherapy for treating or managing many malignant conditions. Phytotherapy and apitherapy are among the best alternatives to chemotherapy as plants and honeybee products are chief sources of phytochemicals with anticancer properties. For example, hesperidin, melittin, apamin, artepillin, 10-hydroxy-2-decenoic acid (10-HDA), Major Royal Jelly Proteins (MRJP), jelleins, royalisin and caffeic acid phenethyl ester are important plant and bee engineered product constituents which by inducing apoptosis and arresting cell cycle control the proliferation of cancer cells. In general, this review highlights problems related to cancer treatment using chemicals. It discusses phytotherapy and apitherapy as an alternative to chemotherapy, while plants and bee products rich in natural anticancer compounds have greater potency to treat cancer.

Keywords


Apitherapy, Bee engineered products, Chemotherapy, Phytochemicals, Phytotherapy, Side effects.

References