Informatics Publishing Limited

V. Kadam Trupti ¹, S. Waghmare Sneha ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Aloe vera is a herb disseminated all through the world. Aloe vera is one of the plant animal varieties which have numerous uses to humanity. It has been broadly utilized for a long time as an option solution furthermore as a corrective item. Due to its restoring, calming and mending properties, it has been utilized for different therapeutic diseases like peptic ulcers, digestive issues, skin bothering and different skin sores. An examination of writing uncovered some eminent pharmacological exercises of the plant, for example, mitigating, antiviral and antitumor, anxiolytic, hostile to maturing impact, sterile, improve safe framework, hypoglycemic, cytotoxic, antiulcer and antidiabetic impacts, antibacterial impact, cell reinforcement, cardiovascular impact, wound healing, antioxidant, antiseptic. Aloe vera is one of the plant animal categories which has various uses to humanity. It has been broadly utilized for ages as an option drug furthermore as an issue item. Likewise, it has been discovered to be useful in oral issues like gingivitis and periodontitis and different parasitic and viral infections. However, the employments of this plant are well known to people since quite a while now, still its uses in dentistry are not broad. The survey here underlines the incredible criticalness of this ordinarily discovered plant.

Keywords

Aloe vera, Pharmacological Activities, Chemical Constituents.

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S. Waghmare Sneha ¹, V. Kadam Trupti ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In the late years, exploratory and innovative progressions have been made in the innovative work of novel medication conveyance frameworks by overcoming physiological inconveniences, for example, short gastric habitation times and capricious gastric purging times. A few methodologies are as of now used in the prolongation of the gastric habitation times, including floating medication conveyance frameworks, swelling and stretching frameworks, polymeric bioadhesive frameworks, adjusted shape frameworks, high-thickness frameworks and other deferred gastric exhausting gadgets. The administration of sickness through solution is entering another period in which developing number of novel medication conveyance frameworks are continuously utilized and are accessible for helpful utilization. Oral maintained discharge gastroretentive measurements structures offer numerous favorable circumstances for medications with assimilation from upper parts of gastrointestinal tract and for those acting mainly in the stomach, enhancing the bioavailability of the pharmaceutical. Floating Gastroretentive Drug Delivery Systems (FGRDDS) is one among the gastroretentive measurements structures used to accomplish delayed gastric living arrangement time. The reason for composing this audit on skimming medication conveyance frameworks (FGRDDS) was to arrange the late writing with unique concentrate on the important instrument of floatation to accomplish gastric maintenance. The late advancements of FGRDDS including the physiological and definition variables influencing gastric maintenance, methodologies to plan single-unit and numerous unit coasting frameworks, and their arrangement and detailing angles are secured in point of interest. This survey likewise compresses the in-vitro strategies, in vivo studies to assess the execution and application of floating frameworks, and applications of these frameworks.

Keywords

Floating Gastroretentive Drug Delivery System (FGRDDS), Single Unit, Multiple Units, Recent Trends, In Vitro-In Vivo Evaluation.

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S. Zope Janhavi ¹, L. Sonawane Pradnya ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In recent years scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Floating drug delivery systems are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. Floating drug delivery systems are the systems which are retained in the stomach for a longer period of time and there by improve the bioavailability of drug. The single unit dosage forms have the disadvantage of a release all or nothing during emptying process while the multiple unit particulate system pass through the GIT to avoid the vagaries of gastric emptying and thus release the drug more uniformly. The uniform distribution of these multiple unit dosage forms along the GIT could result in more reproducible drug absorption and reduced risk of local irritation. The purpose of designing multiple-unit dosage form is to develop a reliable formulation that has all the advantages of a single-unit form and also is devoid of any of the above mentioned disadvantages of single unit formulations. This review explains briefly about advantages, disadvantages, mechanism, types, factors, evaluation and application of these systems.

Keywords

Gastro-Retentive Floating Drug Delivery System, Advantages, Disadvantages, Mechanism, Evaluation.

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Gunjan L. Zope ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In recent years the novel technology of floating drug delivery system formulations are designed for the new drugs for oral targeted drug delivery. The drugs are delivered by conventional dosage forms are having very short residence time, but the drugs which are act in stomach are have more residence time. The floating drug delivery systems are of particular interest for drugs that are locally active and narrow absorption window in stomach. Systems which are retained in the stomach for a longer period of time and there by improve the bioavailability of drugs. In this review the various advantages are given which are very important for controlled drug delivery system. Floating drug delivery systems have a bulk density less than gastric fluids. When the system floats on gastric contents the drug is released slowly at the desire rate from system. The polymers are suitable for floating drug delivery systems are covered in this review.

Keywords

Floating Drug Delivery System, Mechanism and types of FDDS, Evaluation of FDDS.

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A. B. Darekar ¹, S. Zope Janhavi ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

The world pharmaceutical industry has been changing profoundly in the last decade. Intensive globalization, increased competitiveness and the fight for global market shares create new challenges for pharmaceutical companies. Fast globalization definitively reinforces the consolidation of the world Pharmaceutical industry . The current shift in the marketing strategy is work by multinational Pharmaceutical Companies. It is now High - end development that is being carried out by leading companies. And, increasingly, other companies are finding themselves competing against, or working with, new innovation - based companies. My study focuses on objectives, importance, levels, theories, functions and types of pharmaceutical management and also pharmaceutical marketing, difference between general marketing and pharmaceutical marketing. Also study the overlook on Global Pharma Industry and Indian Pharma Industry. In this study the top 50 companies in 2009 and 2014 year are listed out. Also OTC segments and Pharmaceutical Policy are included in this article.

Keywords

Objectives, Importance, Functions, Difference between General Marketing and Pharmaceutical Marketing, Top 50 Companies in 2009 and 2014, OTC, Pharmaceutical Policy.

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L. Sonawane Pradnya ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

The recent patented literature has concluded that there is an increasing interest in the novel dosage forms which retained in stomach for a longer period of time. Bilayer floating drug delivery system is new era for development of controlled release formulation. Bilayer floating drug delivery system is combined principle of bilayer technology as well as floating tablet is suitable for two incompatible drugs. The dosage form contains one sustain release layer and other is immediate layer. The immediate release layer is used to maintain dose. The floating dosage form can be prepared as tablet, capsule by adding suitable ingredients as well as adding gas generating agents.

Keywords

Gastroretentive Dosage Forms, Bilayer Floating Drug Delivery System, Immediate Layer, Control Release Layer.

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T. V. Kadam ¹, A. B. Darekar ¹, S. B. Gondkar ², R. B. Saudagar ³

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In these studies describes a simple, accurate, precise and cost effective UV-visible spectrophotometric method for the estimation of Azelaic acid in pure and pharmaceutical formulations. The method is based on the measurement of absorbance of Azelaic acid solution in Phosphate buffer pH 6.8 at 204nm in the wavelength range of 200-400nm. The method obeys Beer's Lambert's law in the selected concentration range10-50 μg/ml in selected media. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery study shows that the method was not affected by the presence of common excipients in tablets. The parameters like linearity, precision, accuracy, sensitivity study i.e. limit of detection and limit of quantitation were studied according to International Conference on Harmonization (ICH) guidelines. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation which proves suitability of proposed method for routine estimation of Azelaic acid in pure and pharmaceutical formulations.

Keywords

UV-Visible Spectrophotometer, Method Development, Azelaic Acid.

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B. Desale Kishor ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Niosomes are non-ionic surfactant formation of vesicles by hydrating mixture of cholesterol and other lipids with or without incorporation. They are vesicular system that can be used as carriers of amphiphilic and lipophilic drugs. Niosomes are biodegradable, biocompatible, nonimmunogenic and exhibit flexibility in their structural characterization. Niosomes are preferred over liposomes because the former exhibit high chemical stability and economy. Different novel approaches used for delivering these drugs include liposomes, microspheres, nanotechnology, microemulision antibody loaded drug delivery, implantable pumps and niosomes. Niosomes are widely studied as an alternative to liposomes. They improve the therapeutic performance of the drug molecules by delayed clearance from the circulation, protecting drug from biological environment and restricting effects to target cells. This review article focuses on the advantages, disadvantages, preparation methods, factors affecting, characterizations, invitro methods, drug release kinetics, and application of niosomes.

Keywords

Niosomes, Vesicles, Biological Environment, Composition.

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Gunjan L. Zope ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In recent years the novel technology of floating drug delivery system formulations are designed for the new drugs for oral targeted drug delivery. The drugs are delivered by conventional dosage forms are having very short residence time, but the drugs which are act in stomach are have more residence time. The floating drug delivery systems are of particular interest for drugs drugs that are locally active and narrow absorption window in stomach. System which are retained in the stomach for a longer period of time and there by improve the bioavailability of drugs. In this review the various advantages are given which are very important for controlled drug delivery system. Floating drug delivery system have a bulk density less than gastric fluids. When the system floats on gastric contents the drug is released slowly at the desire rate from system. The polymers are suitable for floating drug delivery system are covered in this review.

Keywords

Floating Drug Delivery System, Mechanism and Types of FDDS, Evaluation of FDDS.

Full Text

     

S. Waghmare Sneha ¹, V. Kadam Trupti ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Systemic anti-infective agents are progressively utilized as a part of the treatment of periodontal contaminations. Whilst these medications are utilized basically on an experimental premise, a few doctors battle that discerning utilization of anti-infective ought to be the standard because of their wide ill-use and worldwide development of antiinfective safe living beings.

This is an audit of the standards and balanced anti-infective treatment, treatment objectives, drug conveyance courses and different anti-toxins utilized as a part of the administration of periodontal infections. The accessible information demonstrate, all in all, that mechanical periodontal treatment alone is satisfactory to enhance or determination the clinical condition as a rule, however adjunctive anti-infective agents, delivered systemically, can improve the impact of help in particular circumstances. This is especially valid for forceful periodontitis in patients with summed up systemic ailment that may influence host safety, and in the event of poor reaction to customary mechanical treatment. This article gives a redesign on systemic anti-infective treatment for the treatment of periodontitis.

Keywords

Anti-Infective Agents, Periodontitis, Metronidazole, Tetracycline, Clindamycin.

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V. Kadam Trupti ¹, S. Waghmare Sneha ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Acne vulgaris is a standout amongst the most widely recognized skin issue of pilosebaceous follicle described by papules, knobs, growths, comedones, pustules and regularly scars essentially scattered on the face, midsection and upper back. Pimple inflammation is a typical skin ailment that includes individual of all ages. Skin inflammation is delivered by the gram positive anaerobic microorganism (Propionibacterium acnes) and perceived as discharge framing microbes. Diverse parts of restorative plants and dermatological medications are utilized for the treatment of skin inflammation. In topical specialists; benzoyl peroxide, anti-infection agents, retinoids, and so on are the backbone of treatment; can be given in combination. While systemic treatment incorporates oral anti-microbials, hormonal therapy, and isotretinoin, contingent on the need of patients it must be chosen. Physical treatment in the type of injury evacuation, photograph help is likewise useful in few of them. Since different old and new topical and systemic specialists are accessible to treat acne vulgaris, it at some point confound treating dermatologist.

Keywords

Acne Vulgaris, Propionibacterium Acnes, Staphylococcus Epidermidis.

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