Informatics Publishing Limited

Rakesh Saini ¹, Saurabh Chaturvedi ¹, A. N. Kesari ¹, Rijuved Garg ², Amita Verma ³

Affiliations
1 Dept. of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-08020, (U. P.), IN
2 Department of Pharmacy, Aligarh College of Pharmacy, Aligarh (U.P), IN
3 Department of Pharmacy, Allahabad Agriculture Deemed University, Allahabad (U.P), IN

Abstract

1, 2, 3 benzotriazole derivative also show several pharmacological activities viz.example. Antimicrobial activity, Anti inflammatory, Anti analgesic activity, Anticancer etc. On the basis of our observation the parent research work was carried out to synthesize 1, 2, 3 triazole substituted 1, 3, 4 oxadiazoles and to further evaluate Analgesic activity. Synthesis of (ethyl 2- (1H Benzo [d] [1, 2, 3] triazole-1-yl] acetate) and (2H-benzo [d] [1,2,3] triazole-1-yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and ¹H-NMR specteoscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on albino rats. The present investigation deals with the synthesized compounds possessing good Analgesic activity.

Keywords

Hydrazine, Benztriazole, Analgesic Activity.

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Saurabh Chaturvedi ¹, Rakesh Saini ¹, A. N. Kesari ¹, Awani Rai ¹, Neelotma Maurya ¹, M. Shahar Yar ²

Affiliations
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN

Abstract

A new series of NSAID’S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.

Keywords

NSAID’S, Aspirin, Anti-Platelet Agents, Pyrrole.

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Rakesh Saini ¹, Awani K. Rai ¹, A. N. Kesari ¹, M. Shahar Yar ²

Affiliations
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, IN
2 Department of Pharmacy, Jamia Hamdurd, New Delhi, IN

Abstract

Synthesis of (ethyl 2-(1H Benzo [d] [1, 2, 3] triazole-1-yl] acetate) and (2H-benzo [d] [1, 2, 3] triazole -1-yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and ¹H-NMR spectroscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on Streptococcus aureus and Esteria coli. The present investigation deals with the synthesized compounds possessing good antimicrobial activity.

Keywords

Esterification, Benztriazole, Antimicrobial Activity.

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