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Kesari, A. N.
- Synthesis and Analgesic Activity of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles
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Authors
Affiliations
1 Dept. of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-08020, (U. P.), IN
2 Department of Pharmacy, Aligarh College of Pharmacy, Aligarh (U.P), IN
3 Department of Pharmacy, Allahabad Agriculture Deemed University, Allahabad (U.P), IN
1 Dept. of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-08020, (U. P.), IN
2 Department of Pharmacy, Aligarh College of Pharmacy, Aligarh (U.P), IN
3 Department of Pharmacy, Allahabad Agriculture Deemed University, Allahabad (U.P), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 292-295Abstract
1, 2, 3 benzotriazole derivative also show several pharmacological activities viz.example. Antimicrobial activity, Anti inflammatory, Anti analgesic activity, Anticancer etc. On the basis of our observation the parent research work was carried out to synthesize 1, 2, 3 triazole substituted 1, 3, 4 oxadiazoles and to further evaluate Analgesic activity. Synthesis of (ethyl 2- (1H Benzo [d] [1, 2, 3] triazole-1-yl] acetate) and (2H-benzo [d] [1,2,3] triazole-1-yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and 1H-NMR specteoscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on albino rats. The present investigation deals with the synthesized compounds possessing good Analgesic activity.Keywords
Hydrazine, Benztriazole, Analgesic Activity.- Synthesis and Evaluation of Pyrrole Derivative Conjugates of Aspirin as Anti-Platelet Agents
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Authors
Saurabh Chaturvedi
1,
Rakesh Saini
1,
A. N. Kesari
1,
Awani Rai
1,
Neelotma Maurya
1,
M. Shahar Yar
2
Affiliations
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 22-25Abstract
A new series of NSAID’S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.Keywords
NSAID’S, Aspirin, Anti-Platelet Agents, Pyrrole.- Synthesis and Biological Evaluation of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles
Abstract Views :230 |
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Authors
Affiliations
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, IN
2 Department of Pharmacy, Jamia Hamdurd, New Delhi, IN
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, IN
2 Department of Pharmacy, Jamia Hamdurd, New Delhi, IN