Informatics Publishing Limited

A. K. Meena ¹, Brijendra Singh ², Uttam Niranjan ², A. K. Yadav ², A. K. Nagaria ², Kiran ¹, A. Gaurav ², Vertika Gautam ², R. Singh ²

Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, Patiala-147001, Punjab, IN
2 School of Pharmaceutical Sciences, Shobhit University, Meerut, UP, IN

Abstract

Acacia nilotica (Linn.) Willd. Ex Del., is a medicinal tree, belonging to the Leguminosae family and sub-family Mimosaceae, a moderate sized, spiny, evergreen tree found throughout India, known to be rich in phenolics, consisting of condensed tannin and phlobatannin, gallic acid, (+) catechin, (-) epigallocatechin-7-gallate, and has been used for treatment of viral (colds, bronchitis), bacterial (diarrhoea), amoeboid (dysentery), fungal, bleeding piles and leucoderma diseases. The presented review summarizes the information concerning the botany, ethnopharmacology, phytochemistry, biological activity and toxicity of the Acacia nilotica Linn.

Keywords

Acacia nilotica (Linn.), Medicinal Tree, Ethnopharmacology, Toxicity.

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A. K. Meena ¹, Uttam S. Niranjan ², A. K. Yadav ², Brijendra Singh ², A. K. Nagaria ², A. Gaurav ², M. M. Rao ³

Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, Patiala-147001, Punjab, IN
2 School of Pharmaceutical Sciences, Shobhit University, Meerut, UP, IN
3 National Institute of Ayurvedic Pharmaceutical Research, Patiala –147001, Punjab, IN

Abstract

Vitex negundo Linn. is an large shrubs or small trees which is used in several traditional medicines to cure various diseases. This shrub has been known to posses hepatoprotective, antioxidant, anti-inflammatory, analgesic and antifungal activity. A wide range of chemical compounds including polyphenolic, terpenoids , glycosidic iridoids and alkaloids are present in this shrubs. Vitegnoside, negundoside, agunside, 5,3- dihydroxy-7,8,4-trimethoxy flavanone, 7,8-dimethyl herbacetin 3- rhamnoside etc. have been isolated from this plant. The presented review summarizes the information concerning the botany, ethnopharmacology, phytpchemistry, biological activity and toxicity of the Vitex negundo shrubs.

Keywords

Vitex negundo Linn, Antioxidant, Phytpchemistry, Antiinflammatory, Toxicity.

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Ajay Kumar Meena ¹, Uttam Singh ², Arjun Singh ³, Sudeep Mishra ³, M. M. Rao ¹, M. M. Padhi ³, Ramesh Babu ³, A. Gaurav ²

Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, Patiala- 147001, Punjab, IN
2 School of Pharmaceutical Sciences, Shobhit University, Meerut, UP, IN
3 Central Council for Research in Ayurveda and Siddha (CCRAS), Janakpuri, Delhi-110058, IN

Abstract

Vitex negundo Linn (Five-leaved chaste tree), Hindi-Nirgundi, Sanskrit-Sindhuvara, Tamil and Malyalam-Vennochi, Telugu-Nalla vavili and Punjabi-Marwan (Family: Verbenaceae), is an important medicinal plant found throughout India. All parts of this plant especially the leaf and ischolar_main extracts are being used in various formulations in Ayurveda and Unani systems of medicine. Vitex negundo Linn is pungent, bitter and astringent in taste and according to Ayurveda , it alleviates vata and kapha doshas, but aggravates pitta dosha. It possesses light and dry attributes. Its leaves and seeds are widely used externally for rheumatism and inflammations of joints and also reported to have insecticidal properties. Internally, decoction of its leaves is taken as diuretic, expectorant, vermifuge, tonic and febrifuge. The chemical components of the essential oil of leaf isolated from the plant are used to treat colds and coughing spells. Vitex negundo Linn is used in Classical Ayurvedic Preparations like Nirgundi kalka, Nirgundi ghrta, Nirgundi kvatha, Vranasodhana taila, Visagarbha taila etc. The evaluation studies of Pharmacopoeial standards, phytochemical parameters suggested that the observed physiochemical parameters are of great value in quality control and formulation development of Vitex negundo Linn. Physicochemical parameters like preliminary characteristics, toxic heavy metals, and aflatoxin analysis were carried out. The study revealed that the results on different parameters of the crude drug will be useful in identification and control of adulterations.

Keywords

Ayurveda, Vitex negundo Linn, Toxic Metals, Aflatoxin and Quality Control.

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