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A. Julius ¹, Ramachandran Vedasendiyar ², Archana Devakannan ³, Sujatha Rajaraman ⁴, Balamurugan Rangasamy ⁵, V. Saravanan ¹

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath University, Pallikaranai, Chennai-600 100, IN
2 Department of Biochemistry, Bharath University and Lab Incharge, Public Health and Preventive Medicine, Govt of Tamilnadu, IN
3 Public Health and Preventive Medicine, IN
4 Ashok Nagar, Tamilnadu, IN
5 Shree Manakula Vinayagar Medical College and Hospital, Pondicherry, IN
6 Department of Biochemistry, Sree Balaji Dental college and Hospital, Bharath University, Pallikaranai, Chennai-600 100, IN

Abstract

Objective is to study the Plants that have served as a rich source of medicine including anti-cancer drugs. Research has shifted from the study of using extracts of whole or parts of plants to single active principles. Identification of cytotoxic agents led to the development of anticancer therapeutics with significant success but having severe side effects. Recent advances in understanding the molecular basis of cancer and development of high thorough screening methodologies have led to the discovery of novel therapies in the form of target-based drugs. Plant metabolites like flavonoids have fewer side effects and predominantly act by their capacity to scavenge free radicals, enzyme inhibition, and/or antiproliferative activity. Hesperidin is a biologically active flavonoid, is commonly found in citrus fruits and is used in Chinese medicine. It has been shown to have several useful pharmacological properties including blood lipid lowering activity.

Keywords

Hesperidin, Citrus Fruits, Chemopreventive Activity, Liver Cancer, Reducing Cholesterol.

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K. Pramila ¹, A. Julius ²

Affiliations
1 Bharathiyar University, Coimbatore, IN
2 Department of Biochemistry, Sree Balaji Dental College and Hospital, Pallikaranai, Bharat Institute of Higher Education and Research (BIHER), IN

Abstract

The aim of this study focused on the beneficial effect of EGCG which possess direct antioxidant potential in scavenging the free radicals. Therefore, EGCG was considered as one of the natural antioxidant in improving the quality of life by preventing cardiovascular diseases.

Keywords

Antioxidant, Free Radicals, Cardiovascular Disease, Scavenging, EGCG-Epigallocatechin Gallate, 2,2 Diphenyl-1-Picrylhydrazyl (DPPH), Ferric Reducing Antioxidant Power (FRAP).

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K. Pramila ¹, A. Julius ²

Affiliations
1 Bharathiyar University, Coimbatore. Sree Balaji Dental College and Hospital, Bharat Institute of Higher Education and Research (BIHER), Pallikaranai, Chennai – 600100., IN
2 Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharat Institute of Higher Education and Research (BIHER), Pallikaranai, Chennai – 600100., IN

Abstract

This study shows the potential effect of EGCG in DCM induced rats by exerting anti- hyperglycemic, anti-hyperlipidemic and anti-fibrotic effects. Hence EGCG a natural occurring compound have important clinical implications in terms of prevention and progression of diabetic cardiomyopathy.

Keywords

DCM– Diabetic Cardiomyopathy, Anti-Hyperglycemic, Anti-Hyperlipidemic, Anti-Fibrotic, EGCG- Epigallocatechin Gallate.

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A. Julius ¹, B. Durga ²

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College & Hospital, BIHER, IN
2 Department of Biochemistry, Prince Shri Venkateshwara Arts and Science College, Chennai, IN

Abstract

From ancient period, the plants are used as a treatment for dreadful disease due to the presence of medicinal value. Even in modern generation, many herbal plants are focused in research field to brief about its higher potential of efficacy in curing & also reducing the side effects. In this study, we reviewed the traditional plant physalis minima Linn which is commonly called as native gooseberry are used in treating several disease due to the presence of phytochemical constituent having properties such as anti-inflammatory,antioxidant, anti-proliferative, antibacterial. This paper will give brief review about the all parts of the plant of physalis species to signify the good efficacy on the disease condition.

Keywords

Physalis Minima, Phytochemical Constituent, Anti-Inflammatory, Antioxidant, Anti-Proliferative, Antibacterial.

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A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. Raghavendra Jayesh ⁴, Shobakishore ⁵

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, IN
3 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai,, IN
4 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, IN
5 Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Diabetes and aging are associated with reduced vascular endothelial function, 20 controls and 20 subjects with type 2 diabetes age 40 participated, a series of experiments were conducted to examine the interrelationship between age, Type 2 Diabetes Mellitus and endothelial renal function. This complication is first manifested as an increase in UAE [microalbuminuria] which progresses to over albuminuria and then to renal failure In subjects with diabetes age < 40 were more prone to nephropathy which progress to End Stage Renal Disease [ESRD]

Keywords

Diabetes Mellitus, Aging, Type 2 Diabetes Mellitus, ESRP, Nephropathy.

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A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. Raghavendra Jayesh ³, Shobakishore ⁴

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, Chennai, IN
3 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai, IN
4 Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Diabetes Nephropathy is a major microvascular complication of Diabetes Mellitus and the most common cause of End Stage Renal Disease (ESRD) worldwide. Hyperglycemia, a well recognized pathogentic factor of long term complications of Diabetes Mellitus, generates ROS. This attenuates antioxidative mechanisms through glycation of the scavenging enzymes. Excess amount of ROS modulate activation of protein kinaseC, mitogin activated protien kinares and various cytokines and transcription factors which eventually cause increased expression of extracellular matrix (ECM) genes with progression of fibrosis and end stage renal disease. Therefore, this study was carried out to investigate oxidant and antioxidant status in Diabetic patients for manifesting the progression to diabetic nephropathy.

Keywords

Diabetic Nephropathy, Hyperglycemia, Reactive Oxygem Species, Extracellular Matrix, Oxidative Stress.

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A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. RaghavendraJayesh ³, Shobakishore ⁴

Affiliations
1 Department of Biochemistry, SreeBalaji Dental College and Hospital Bharath Institute of HigherEducation and Research, (Bharath University),Narayanapuram, Pallikaranai, Chennai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, Chennai, IN
3 Department of Prosthodontics, SreeBalaji Dental College and Hospital, Bharath Instituteof Higher Education and Research, (Bharath University),Narayanapuram, Pallikaranai, Chennai, IN
4 Department of Pathology, SreeBalaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Tamm Horsfall Protein or Uromodulin is the most abundant urinary glycoprotein that has a protective function in the bladder mucosal layer. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Using ELISA, the autoantibody level of Tamm Horsfall Protein in serum was determined in Hypertensive Patients and control subjects. A significant percentage of hypertensive subjectshave a greater risk of renal stone formation, with high autoantibodies level to Tamm Horsfall Protein in serum when compared to control subjects. Hence THP acts as a potential biomarker for nephrolithiasis in Hypertensive patients.

Keywords

Tamm Horsfall Protein Hypertension ELISA Autoantibody Nephrolithiasis.

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Sudha Jimson ¹, S. Jimson ², S. Leena Sankari ¹, Lokesh Bhanumurthy ³, A. Julius ⁴

Affiliations
1 Professor, Department of Oral Pathology, Sree Balaji Dental College & Hospital, Chennai, IN
2 Professor & Head, Department of Oral & Maxillofacial Surgery, Tagore Dental College & Hospital, Chennai, IN
3 Reader, Department of Oral & Maxillofacial Surgery, Tagore Dental College & Hospital, Chennai, IN
4 Professor & Head, Department of Biochemistry, Sree Balaji Dental College & Hospital, Chennai, IN

Abstract

Radicular cyst is the common odontogenic inflammatory cyst which arises from the cell rest of malassez. It is asymptomatic and swelling proceeds solely indicating cortical plate expansion radicular cyst is the consequence of pulpal necrosis. The management of radicular cyst is aided by clinical, FNAC and radiographic examination. Diagnosis is confirmed by histopathological examination. Treatment options are based on the extent of the lesion, structure, origin and clinical/systemic condition of the patient. Untreated cyst may expand causing local tissue destruction and further pathological deformity. Management includes non-surgical endodontics and surgical methods like endodontic surgery, decompression, marsupialization or enucleation. This article briefly discusses the clinical features, etiopathogenesis and treatment options for management of radicular cysts.

Keywords

Cyst, MTA, Pathogenesis, Periapical.

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