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Mahdi, Abbas Ali
- Seminal Plasma Lipid Profiles and Lipid Peroxide Levels in Infertile Men
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Affiliations
1 Departments of Biochemistty and Anatomy, K.G.'s Medical College, Lucknow-226 003, IN
2 Department of Biochemistry, K.G. Medical College, Lucknow-226 003, IN
1 Departments of Biochemistty and Anatomy, K.G.'s Medical College, Lucknow-226 003, IN
2 Department of Biochemistry, K.G. Medical College, Lucknow-226 003, IN
Source
Journal of Endocrinology and Reproduction, Vol 3, No 1&2 (1999), Pagination: 20-28Abstract
The present study was undertaken to evaluate the seminal plasma lipids and lipid peroxide levels in fertile and normospermic infertile, azoospermic, oligospermic and asthenospermic men. Spermatozoa and seminal plasma contain considerable amount of lipids, in particular cholesterol and phospholipids, and thus susceptible to oxidative damage. The results show a significant reduction in total lipid and phospholipid levels in normospermic infertile men. Alteration in the lipid content of seminal plasma may adversely affect the membrane structure required for the occurrence of capacitation and acrosome reaction and also lead to an altered sperm function. Moreover, the results also showed significantly elevated seminal plasma lipid peroxide levels in all infertile men, remarkably in normospermic infertile men. It Is concluded that in unexplained infertile couples, one of the reasons for failure of normal fertilisation process may be the perturbed seminal plasma lipid content brought about by free radical mediated lipid peroxidation.Keywords
Infertility, Lipids, Lipid Peroxides, Seminal Plasma.
- Association Between Circulating Inflammatory and Anti-Inflammatory Proteins and Risk of Development of Type II Diabetes Mellitusin Indian Obese Children
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Authors
Himani Kulshrestha
1,
Vani Gupta
1,
Sameeksha Mishra
1,
Supriya Mishra
1,
Shelly Awasthi
2,
Abbas Ali Mahdi
3
Affiliations
1 Department of Physiology, King George’s Medical University, Lucknow (U.P.), IN
2 Department of Paediatrics, King George Medical University, Lucknow (U.P.), IN
3 Department of Biochemistry, King George Medical University, Lucknow (U.P.), IN
1 Department of Physiology, King George’s Medical University, Lucknow (U.P.), IN
2 Department of Paediatrics, King George Medical University, Lucknow (U.P.), IN
3 Department of Biochemistry, King George Medical University, Lucknow (U.P.), IN
Source
International Journal of Medical Sciences, Vol 11, No 1-2 (2018), Pagination: 1-7Abstract
Background and aim: Anti-inflammatory IL-10, omentin-1 and inflammatory visfatin dysregulation play a role in the development of metabolic syndrome. The objective of this study was to evaluate the association between circulating IL-10, omentin-1 and visfatin concentration and risk of development of type II diabetesin obese with MS children.Methods:Total of 220 obese were enrolled in our case-control study. They were divided according to NCEP ATP III criteria into obese without MS (control) and obese with MS (case) based on their BMI-percentile, obese children subdivided into overweight, obese, severally obese on the basis of BMI (percentile). Fasting blood sample was collected to determine biochemical parameters. Serum IL-10, omentin-1and visfatin plasma level was assessed by ELISA kit method. Association of these proteins with biochemical and anthropometric parameters were studied. Results: Obese children with MS showed a borderline significant decrease in serum IL-10 levels, Omentin-1 levels however, significantly increased in visfatin levels as compared to without MS obese children. In correlation analysis, we found all the three proteins were significantly corelated with BMI (percentile) but visfatin was also corelated with fasting plasma glucose. Interpretation and conclusions: Our study supports the hypothesis that abnormal production of IL- 10, omentin-1 and visfatin may contribute to the development of obesity in children, the correlation between MS and the BMI (percentile) may be an effective parameter in identifying obese children and adolescents at risk for MS. Screening the cases with BMI (percentile) for MS is an important factor for establishing an early diagnosis of diabetes.Risk of development of MS may be a diagnostic parameter for obesity-related complications such as Type II DM.Keywords
Interleukin 10, Type II Diabetes Mellitus, HOMA-IR, Obesity, Omentin- 1, Visfatin.References
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