Informatics Publishing Limited

Ajay Kumar Meena ¹, Himanshu Sehgal ¹, M. M. Rao ¹, P. Panda ¹, M. M. Padhi ²

Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, Patiala - 147001, Punjab, IN
2 Central Council for Research in Ayurveda and Siddha, Janakpuri, Delhi- 110058, IN

Abstract

The scientific basis for the statement that plant and their active constituents play an important role in the prevention diseases is continuously advancing. Most sacred herb in Indian mythology, Bael (Bilva), word Bilva means that kills all the diseases has several medicinal properties. As mentioned in Dhanvantri nigantu, in 10^th century that the unripe fruit is sangrahi, the research also shows the same result that unripe fruit is most effective remedy for chronic diarrhea and dysentery without fever. The present review deals with its history, origin, distribution, cultivators, nutritive value, phytochemical properties and therapeutic uses of Aegle marmeolus. It is antidysentary, anti diarrheal, antimicrobial, antipyretic, anti inflammatory, analgesic, cardio protective, antidiabetic, anticancerous, antispermatogenic, radio protective and also cures peptic ulcer and respiratory infections.

Keywords

Aegle marmeolus, Anticancerous, Phytochemical, Diarrhea.

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Ajay Saxena ¹, Pravin Kumar Rai ², Ajay Kumar Meena ¹, Anupam Srivastava ¹, Priyanka Pandey ³, Kiran Shrivastava ⁴, Shikha Sharma ⁵, Gyanendra Dutt Shukla ⁶

Affiliations
1 Department of AYUSH, Ministry of Health and Family Welfare, New Delhi - 110023, IN
2 CCIM, Janakpuri, New Delhi – 110058, IN
3 CGHS, Wellness Center, Devnagar, New Delhi, IN
4 Dravyaguna Department, Kanpur University, (UP), IN
5 National institute of Ayurveda, Jaipur (Raj.), IN
6 Rishikul P G Ayurvedic College, Haridwar (UK), IN

Abstract

In this mechanical era of very fast life style everyone has to face mental and physical stress and nobody has time to spend for his own health purpose. Hence to obey Dincharya and Rutucharya is far away from them. Shift duties, excessive travelling, irregular dietary habits, junk and fast foods etc. are some of the common causes which help in vitiation of Vatadosas. Considering all the above factors, it is very obvious that the ratio of Vatavyadhies is increased and Sandhivata(osteoarthritis) is one of them.

A series of 20 patients suffering from Sandhigata Vata vis-a-vis Osteoarthritis were randomly selected from O.P.D. and I.P.D. of Panchkarma P.G. Department, Rishikul Govt. Ayurvedic P.G. College and Hospital, Hardwar, Uttarakhand, for the purpose of clinical trials of present study. Out of 20 patients, only 16 patients could complete their full follow-up i.e. 3 months. 04 patients had left against their medical advice. Observation and results were drawn on the basis of pain, swelling, tenderness, crepitus, restriction of joint movement, joint stiffness, severity index of OA, VAS scale of pain and health satisfaction criteria. After full observation of therapies, it was found that no. of patient unchanged was 0, whereas, observed mild improvement was found in 5 patients (31.25 %), moderate improvement in 8 patients (50 %) and marked improvement was observed in 3 patients (18.75 %).

 

Keywords

Ayurved, Panchkarma, Sandhigata Vata, Dashmoola, Patients.

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Ajay Kumar Meena ¹, Anshul Sinha ², S. C. Verma ³, M. D. Gupta ², M. M. Padhi ⁴

Affiliations
1 NRIASHRD, CCRAS, Aamkho, Gwalior, (MP), IN
2 National Research Institute for Ayurveda- Siddha Human Resource Development, Gwalior, IN
3 Central Council for Research in Ayurvedic Science, Janakpuri, Delhi –110058, IN
4 Central Council for Research in Ayurvedic Science, Janakpuri, Delhi – 110058, IN

Abstract

Plant derived spices are generally used in foods for flavoring and medicinal purposes. Spices have been shown to possess medicinal value, such as antimicrobial activity, antioxidant, anticancer, anti-inflammatory activity etc. Several spices particularly Tejpatta (Cinnamomum tamala), Souff (Foeniculum vulgare), Jeera (Cuminum cyminum), Methi (Trigonella foenum-graecum), Ajwain (Trachyspermum ammi), Dhaniya (Coriandrum sativum), Kali Mirch (Piper nigrum), Kalonji (Nigella sativa) are used extensively in the Indian diet and in ayurvedic medicines. Development of standard procedure through HPTLC is a new approach which may lead to proper standardization of different spices and ayurvedic drugs based on fingerprinting characteristics. HPTLC Fingerprinting technique is widely employed in pharmaceutical industry in process development, identification and detection of adulterants in herbal product and helps in identification of pesticide content, mycotoxins and in quality control of spices and herbs. The study revealed specific identities for spices/herbal drugs taken which will be useful in identification and control to adulterations of the drugs.

Keywords

Spices, Herbal Drugs, Quality Control, HPTLC Fingerprints, Ayurvedic Medicines.

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Shahin Khan ¹, Ajay Kumar Meena ², Ajay Saluja ¹

Affiliations
1 A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy, Anand, IN
2 Central Council for Research in Ayurvedic Science, Janakpuri, New Delhi, IN

Abstract

Ayurveda has abundant collection of effective formulations against diseases. The polyherbal formulation contains Vernonia anthelmintica, Curcuma longa, Piper longum, Mallotus philippinensis, Operculina turpethum, Terminalia chebula, Butea monosperma, and Red ochre. The present study deals with anthelmintic evaluation of ayurvedic formulation. Various concentrations of polyherbal formulation (10 mg/ml, 20 mg/ml and 30 mg/ml) in 50 ml of normal saline were taken. The results were compared with standard albendazole (10mg/ml, 20mg/ml and 30 mg/ml) and control was taken as normal saline (0.9% NaCl). The results were expressed in terms of time in minutes for the paralysis and time of death of the worms. Paralysis and death time were analyzed using one way ANOVA analysis using Graph pad prism 2.01 Software. The study indicates that polyherbal formulation shows more potent anthelmintic activity than standard reference.

Keywords

Polyherbal Formulation, Krumighattini Tablet, Anthelmintic Activity, Albendazole.

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Ajay Kumar Meena ¹, Brijendra Singh ², Vijay Simha ², V. Gautam ², M. M. Rao ¹

Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, Patiala - 147001 (Punjab), IN
2 School of Pharmaceutical Sciences, Shobhit University, Meerut, UP, IN

Abstract

Ashwagandha is a reputed drug mentioned in the ancient books of Ayurveda and Siddha for the treatment of stress, hypertension, rejuvenative, sound sleep, brain functions and reducing the high cholesterol levels. It is a stout shrub that reaches a height of 170 cm (5.6 ft). For the standardization of this drug Physico-chemical and Phyto-chemical parameters were carried out such as moisture content, ash values, pH values, extractability in water and alcohol were carried out. Thin Layer Chromatography studies were also carried out to ascertain the quality of this drug. The present study summarizes the difference in two places of Withania somnifera Dunal. This study also helps to identify the right place for cultivation of medicinal plants and quality assessment.

Keywords

Withania somnifera Dunal, Ayurveda, Physicochemical, Standardization, Quality.

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Sunil Kumar ¹, Surrinder Koul ², Ajay Kumar Meena ³, A. K. Saxena ⁴, O. P. Suri ⁵, K. L. Dhar ⁵

Affiliations
1 Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, 142 001,, IN
2 Department of Bio-organic Chemistry, IIIM, Jammu Tawi 180001, IN
3 National Institute of Ayurvedic Pharmaceutical Research, Moti Bagh Road, Patiala, IN
4 Division of Pharmacology, IIIM, Jammu Tawi, 180001, IN
5 Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, 142 001, IN

Abstract

Plants, source of various bioactive compounds have played crucial role in development of several clinically useful anticancer agents' viz., vincristin, vinblastin, camptothecin derivatives and taxol. Combretastatin, a potent anticancer molecule was first isolated from plant. In this continuation a series of combretastatin analogues has been synthesized on the basis of our butterfly model with two wings as aryl groups and connecting carbon chain as the body. In present study we have synthesized combretastatin analogues of different substitutions, showed potent anticancer activity against different cell lines in different fashion according to substitution. Compound 6 showed marked anticancer activity against colo-205 cell lines (colon cancer).

Keywords

Combretastatin, Antitumor, Phenyl Acetic Acid, Tubulin Inhibitor.

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Ajay Kumar Meena ¹, Uttam Singh ², Arjun Singh ³, Sudeep Mishra ³, M. M. Rao ¹, M. M. Padhi ³, Ramesh Babu ³, A. Gaurav ²

Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, Patiala- 147001, Punjab, IN
2 School of Pharmaceutical Sciences, Shobhit University, Meerut, UP, IN
3 Central Council for Research in Ayurveda and Siddha (CCRAS), Janakpuri, Delhi-110058, IN

Abstract

Vitex negundo Linn (Five-leaved chaste tree), Hindi-Nirgundi, Sanskrit-Sindhuvara, Tamil and Malyalam-Vennochi, Telugu-Nalla vavili and Punjabi-Marwan (Family: Verbenaceae), is an important medicinal plant found throughout India. All parts of this plant especially the leaf and ischolar_main extracts are being used in various formulations in Ayurveda and Unani systems of medicine. Vitex negundo Linn is pungent, bitter and astringent in taste and according to Ayurveda , it alleviates vata and kapha doshas, but aggravates pitta dosha. It possesses light and dry attributes. Its leaves and seeds are widely used externally for rheumatism and inflammations of joints and also reported to have insecticidal properties. Internally, decoction of its leaves is taken as diuretic, expectorant, vermifuge, tonic and febrifuge. The chemical components of the essential oil of leaf isolated from the plant are used to treat colds and coughing spells. Vitex negundo Linn is used in Classical Ayurvedic Preparations like Nirgundi kalka, Nirgundi ghrta, Nirgundi kvatha, Vranasodhana taila, Visagarbha taila etc. The evaluation studies of Pharmacopoeial standards, phytochemical parameters suggested that the observed physiochemical parameters are of great value in quality control and formulation development of Vitex negundo Linn. Physicochemical parameters like preliminary characteristics, toxic heavy metals, and aflatoxin analysis were carried out. The study revealed that the results on different parameters of the crude drug will be useful in identification and control of adulterations.

Keywords

Ayurveda, Vitex negundo Linn, Toxic Metals, Aflatoxin and Quality Control.

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