Informatics Publishing Limited

Anagha Ranade ¹, Shivani Gayakwad ², Shridhar Chougule ², Amey Shirolkar ³, Sudesh Gaidhani ⁴, Sharad D. Pawar ²

Affiliations
1 Department of Ayurveda, and Regional Ayurveda Institute for Fundamental Research, Pune 411 038, IN
2 Department of Pharmacology, Regional Ayurveda Institute for Fundamental Research, Pune 411 038, IN
3 National Center for Cell Science, Pune 411 007, IN
4 Central Council for Research in Ayurvedic Sciences, New Delhi 110 058, IN

Abstract

Gut microbiota has tremendous potential to influence human physiology in terms of health and disease. Factors like improper diet, lifestyle and stress contribute in development of dysbiosis. Ayurveda emphasizes on the importance of mahasrotasa (GIT system) and its homeostasis in maintenance of health. Pharmacokinetic principles of Ayurvedic pharmacology include Vipaka, commonly referred to as ‘postdigestive irreversible process’ which is closely associated with biotransformation of drugs caused by microbiota. There is evidence that the metabolism of polyphenols by the microbiota can influence their bioactivity. Consequently, inter-individual variation in microbial metabolism could have implications for health benefits of phytochemicals.

Keywords

Ayurveda, Gut Microbiota, Pharmacokinetics, Metabolic Programmes.

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