Informatics Publishing Limited

Gaurav Tiwari ¹, Ruchi Tiwari ², Awani K. Rai ², Vachaspati Dubey ², Anil Sharma ³, Pranay Wal ², Ankita Wal ²

Affiliations
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
3 Gyan Vihar University, Jaipur, Rajasthan, IN

Abstract

Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have revolutionised the therapeutic strategies for the management of periodontal disease progression. The rationale for use of antibiotics in periodontal therapy is based on the concept that bacteria are the primary cause of periodontal diseases and thus treatment should be directed towards controlling the bacterial flora.. The effectiveness of mechanical debridement of plaque and repeated topical and systemic administration of antibacterial agents are limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. Systemic administration of drugs leads to therapeutic concentrations at the site of infection, but for short periods of time, forcing repeated dosing for longer periods. Local delivery of antimicrobials has been investigated for the possibility of overcoming the limitations of conventional therapy. The use of sustained release formulations to deliver antibacterials to the site of infection (periodontal pocket) has recently gained interest. This review summarises the recent developments in the field of intra-pocket drug delivery systems and identifies areas where further research may lead to a clinically effective intra-pocket delivery system.

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Gaurav Tiwari ¹, Awani K. Rai ², Vachaspati Dubey ², Anil Sharma ³, Pranay Wal ², Ankita Wal ²

Affiliations
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), IN
3 Suresh Gyan Vihar University, Jaipur, Rajasthan, IN

Abstract

Chronopharmaceutics covers the fundamentals of the various aspects of chronopharmaceutics in the fields of chronobiology, chronogenetics, chronophysiology, chronopathology, chronopharmacology, chronotherapeutics, chronotoxicology and chronobiotics, and chronopharmaceutical drug delivery research. It discusses different and specific controlled-release systems that are triggered by electrics, diffusion, and chemical-activation and concludes with a description of the regulatory issues along with formulation and manufacturing.Due to advances in chronobiology, chronopharmacology, and global market constraints, the traditional goal of pharmaceutics (e.g. design drug delivery systems with a constant drug release rate) is becoming obsolete. However, the major bottleneck in the development of drug delivery systems that match the circadian rhythm (chronopharmaceutical drug delivery systems: ChrDDS) may be the availability of appropriate technology. The last decade has witnessed the emergence of ChrDDS against several diseases. The increasing research interest surrounding ChrDDS may lead to the creation of a new subdiscipline in pharmaceutics known as chronopharmaceutics. This review introduces the concept of chronopharmaceutics, addresses theoretical/formal approaches to this sub-discipline, underscores potential disease-targets, revisits existing technologies and examples of ChrDDS. Future development in chronopharmaceutics may be made at the interface of other emerging disciplines such as system biology and nanomedicine. Such novel and more biological approaches to drug delivery may lead to safer and more efficient disease therapy in the future.

Keywords

Chronopharmaceutics, Chronopharmacology, Chronotherapeutics, Drug Delivery, Technologies.

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Ankita Wal ¹, Pranay Wal ¹, Rashmi Saxena Pal ¹, Anurag Singh ²

Affiliations
1 Pharmacy Deptartment, PSIT, Kanpur, IN
2 Research Scholar, Pharmacy Deptartment, PSIT, Kanpur, IN

Abstract

Background: India, because of its lavish cultural heritage is rich in its traditional knowledge of treatment of ailments in various forms for the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness. Objective: India having vast ethnic variability, has different disease prevalence patterns. Therefore an attempt has been made to review the practice of different systems of medicines or CAM. Material and Methods: All other forms of treatments (regarded as complementary or alternative medicine) such as homeopathy, herbal therapy, acupuncture, acupressure, magnet, massage, yoga, naturopathy, mud, aroma, colour and gem therapy have been reviewed in detail for its literature available from the various sources. Result: CAM in the form of therapies can also be organized into different categories, which provides safer solution to various complications in the utmost gentle manner. Conclusion: The future prospects of CAM are very promising in India and the need is to study out and implement these systems of medicine in a systemic and planned way.

Keywords

Complementary, Alternative, Therapy, Medicine.

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Pranay Wal ¹, Rashmi Saxena Pal ¹, Ankita Wal ¹, Yogendra Pal ¹

Affiliations
1 Pharmacy Dept., PSIT, Kanpur, IN

Abstract

AIM: To evaluate the features of plant based Diabmag sugar alternate. OBJECTIVE: To analyze Diabmag, herbal based sweetener on various parameters. MATERIALS AND METHODS:120 subjects were randomly selected, at a health camp held at a renowned park at Kanpur. A questionnaire was asked to be completed by the participants that included questions about various aspects of Diabmag formulation. RESULTS: Taste, intensity, practicality and after taste were analyzed on the basis of results of questionnaire. CONCLUSION: Diabmag is a safe, efficient and compatible sugar alternate.

Keywords

Diabmag, Questionnaire, Sugar, Safe, Alternate.

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Rashmi Saxena Pal ¹, Nikita Saraswat ¹, Yogendra Pal ¹, Pranay Wal ¹, Ankita Wal ¹, A. K. Rai ¹

Affiliations
1 NH-2, Bhauti, Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur (U.P) 209305, IN

Abstract

Background: According to WHO (World Health Organization), more than 50 million pre-school children and approximately 2 billion adults are overweighed and more than half a billion are obese. Obesity is a matter of concern for population worldwide. For the treatment of obesity, the use of Ayurveda, as well as traditional forms of medication, has turned widely popular amongst the Indians. In fact, the world population is adopting many traditional medications, herbs, and formulations as a part of the lifestyle to cure obesity. Natural sources have always proved to bring long-term results as well as considered to be efficacious and safe as compared to the trending weight-loss product market. Objective: The objective of the paper is to evaluate and proclaim the effectiveness of extract of powdered poly herbs prepared in the laboratory from sources such as Ajowan fruit, Cinnamon bark, Leaves of pomegranate, Garlic buds and dried fruits of black pepper which could be potential anti-obesity source. Methods: The experiment was performed on Wistar male rats four weeks old weighing approx. 200-250g. They were administered the prepared herbal extract for evaluating the anti-obesity action. Throughout the experiment, the rats were divided into six groups with 6 rats in each group. Group I was considered as Normal Control Group hence normal pellet diet was given and no drug was administered to the rats of this group. Obesity was induced through HFD (high-fat diet) in standard and treated groups (Group II to VI). Group II was not given any medication to reduce obesity whereas a standard dose of Orlistat 5 mg/kg b. wt and was administered in Group III. Groups IV, V, VI were administered with Alcoholic Extracts containing different concentrations of Poly Herbal Powder and the anti-obesity action was recorded. The food intake, body weight, serum lipid profiles like, total TG, total serum cholesterol (TC), High-density lipoprotein (HDL), Low-density lipoprotein (LDL), Very Low-density lipoprotein VLDL, Blood glucose. Results: The average results of all groups were noted, plotted and analyzed where the results pointed out the anti-obesity activity in all groups. The standard group reported anti-obesity action whereas the treated groups with the maximum concentration was reported to be comparatively goodin anti-obesity action as compared to the standard group. Conclusions: The results concluded that the formulated herbal extract from powdered sources of dried herbs proved to be effective in the treatment of obesity. Multiple parameters were evaluated which directly pointed out that the extract is effective in relieving from the problem of obesity. The most effective treatment of the three concentrations of the prepared herbal extract was found to be Group VI HFD + Prepared Extract 200 mg/kg b. wt.

Keywords

Obesity, Polyherbal Extract, High-Fat Diet (HFD), High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Herbal Extract, Serum Total Cholesterol (TC).

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