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Bag, Arijit
- A Study of Changes in Liver Function, Pancreatic Enzyme Levels, and Creatine Phosphokinase Level in Cases of Acute Organophosphorus Poisoning
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Authors
Arijit Bag
1,
Kaushik Ghosh
1,
Ambarish Bhattacharya Saumyajit Ghosh
1,
Amitava Acharyya
2,
Mrinal Pal
3
Affiliations
1 Departments of Medicine, Burdwan Medical College, Burdwan - 713104, West Bengal, IN
2 Howrah, West Bengal, IN
3 Department of Biochemistry, Burdwan Medical College, Burdwan - 713104, West Bengal, IN
1 Departments of Medicine, Burdwan Medical College, Burdwan - 713104, West Bengal, IN
2 Howrah, West Bengal, IN
3 Department of Biochemistry, Burdwan Medical College, Burdwan - 713104, West Bengal, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 3 (2015), Pagination: 70-75Abstract
Organophosphorus (OP) compounds are widely used insecticides in this part of the world. Organophosphorus compounds are responsible for a majority of suicidal attempt in India due to its easy availability. To determine the effect of organophosphorus compounds on hepatobiliary, pancreas, and muscular system and association of biochemical markers of respective systems to determine the outcome. This is a single-center, observational, prospective study conducted on 150 organophosphorus (OP) poisoning patients diagnosed clinically and with circumferential evidence. After admission, relevant biochemical markers of respective systems were done with standard guidelines. In patients where abnormality was found in serum amylase and lipase levels, ultrasonography and/or contrast-enhanced computed tomography evaluation of abdominal organs was done as per clinical indication. Among 150 patients, 17 (11.33%) patients succumbed to death. A significant association was observed between lipase level and treatment outcome. The odds ratio of death among high-level lipase group was 11.54 times higher than normal lipase group. Only four patients developed isolated creatine phosphokinase elevation with features suggestive of rhabdomyolysis. Isolated hepatic enzyme derangements found in only one case, whereas 5 patients had concurrent elevated lipase level. Organophosphorus-induced pancreatitis with or without hepatitis is often overlooked in acute poisoning which may be fatal. An early intervention often reverses this dreaded complication.Keywords
Chemical Hepatitis, Creatine Phosphokinase, Lipase, Organophosphorus Poisoning.
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- Transition Probability Approach for Direct Calculation of Coefficients of Configuration Interaction Wave Function
Abstract Views :187 |
PDF Views:68
Authors
Affiliations
1 Division of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741 246, IN
1 Division of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741 246, IN
Source
Current Science, Vol 113, No 12 (2017), Pagination: 2325-2328Abstract
To reduce the computation cost of configuration interaction (CI) method, a novel technique is used to calculate the coefficients of doubly excited determinants directly from orbital energies, orbital overlap matrix and electron population obtained from Hartree–Fock level run. This approach to approximate the coefficients of CI wave function is termed as transition probability approximated CI (TPA-CI). In principle, calculated dynamical electron correlation energies of TPA-CI and full CI (FCI) are equivalent. It is observed that computed TPA-CI correlation energies of hydrogen, water, ammonia and ozone are close to the FCI values, within 5% error. The potential energy curve of hydrogen molecule is also studied, and it is found that the energy is minimum at its equilibrium bond length.Keywords
Configuration Interaction, Potential Energy Curve, Transition Probability Approximation, Wave Function.Full Text
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