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Kamath, Asha
- Role of Serum HIF-1alpha and VEGF-A as an Angiogenic Factors in Women with Heavy Menstrual Bleeding
Authors
1 Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal - 576104, Karnataka, IN
2 Melaka Manipal Medical College, Manipal University, Manipal – 576104, Karnataka, IN
3 Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal - 576104, Karnataka, IN
4 Department of Community Medicine, Kasturba Medical College, Manipal University, Manipal - 576104, Karnataka, IN
Source
Indian Journal of Science and Technology, Vol 9, No 37 (2016), Pagination:Abstract
Aim: The purpose of this study to evaluate the levels of potent angiogenic factors, such as VEGF-A (Vascular Endothelial Growth Factor-A) and HIF-1 alpha (Hypoxia Induced Factor) in patients with Heavy Menstrual Bleeding (HMB). In addition, serum copper and ceruloplasmin as modulator of angiogenesis were investigated. We evaluated haemoglobin concentration and ET (Endometrial Thickness) as clinical and laboratory features of disease to investigate role of angiogenesis in etiology of HMB. Methods/Analysis: This case-control study was conducted on 120 females aged between 22-48 years with history of bleeding excessively for more than 3 months and 120 control samples. 5 ml of blood sample was collected from HMB patients and controls. Serum HIF-1 alpha, VEGF-A were measured by ELISA kit method. Copper was estimated using 3,5-dibromo-2-pyridylazo-N-ethyl-N-3 sulphopropyl aniline. Ceruloplasmin was estimated using P-Phenylenediamine (PPD) oxidase method. Endometrial thickness was obtained from Ultrasonography (USG). Hemoglobin was estimated using Drabkin’s method. Findings: We observed higher concentration of VEGF-A as well as HIF-1 alpha in patient with HMB as compared to healthy women. The ROC (Receiver Operating Characteristic) curve was used to obtain optimal cutoff of VEGF-A as well as HIF-1 alpha to discriminate the HMB. Conclusion: Increase serum HIF-1alpha, VEGF-A and copper might be seen as predictors of HMB and increase efficacy of treatment.Keywords
ET (Endometrial Thickness), HIF-1 Alpha (Hypoxia Induced Factor), HMB (Heavy Menstrual Bleeding), VEGF-A (Vascular Endothelial Growth Factor-A).- An Observational Study on Factors Associated with Pre- Eclampsia/Gestational Hypertension among Pregnant Women Attending a Tertiary Care Hospital at Udupi
Authors
1 Assistant Professor, Symbiosis Institute of Health Sciences, Symbiosis International University, Pune, IN
2 Associate Professor, Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, IN
3 Professor and HOD, Department of OBG, Dr. TMA Pai Hospital, Udupi, Manipal Academy of Higher Education, Manipal, IN
4 Professor & Head, Department of Data Science, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, IN
Source
Indian Journal of Public Health Research & Development, Vol 11, No 2 (2020), Pagination: 218-223Abstract
Introduction: Pre-Eclampsia and Gestational Hypertension are often categorised under the complicated hypertensive disorders in pregnancy. The present study was carried out to observe the maternal age distribution, family history of hypertension, blood group distribution, gravida status, gestational age at delivery and baby weight distribution among healthy pregnant women and pregnant women with PE/GH attending a tertiary care hospital at Udupi district.
Methodology: After obtaining the consent from pregnant women fulfilling the criteria for the study, details on maternal age distribution, family history of hypertension, blood group distribution, gravida status, gestational age at delivery and baby weight distribution were obtained from the patient records. Healthy pregnant were defined as those who had no complications in pregnancy till delivery and cases were defined as the ones who developed GH/PE anytime after 20 weeks of gestation.
Results: The present study identified that among Control 16.7% and among Case 29% had family history of hypertension. Larger percentage of women had blood group of O+ among control whereas it was B+ among case. Among Case, 48.6% women delivered at ≤37 weeks. The babies born to Control women had a birth weight of 3.07 ± 0.38 kg as compared to babies born to women with Gestational Hypertension/Pre-eclampsia which was 2.6 ± 0.32 kg.
Conclusion: The study could identify the distribution pattern of maternal age, family history of hypertension, blood group, gravida status, gestational age at delivery and baby birth weight and among healthy pregnant women and pregnant women with PE/GH attending a tertiary care hospital at Udupi district.