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Ahirwar, B.
- Effect of Terminalia chebula Fruits on Lipid Profiles of Rats
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Journal of Natural Remedies, Vol 3, No 1 (2003), Pagination: 31-35Abstract
Objective: To study the effect of Terminalia chebula on serum lipids in hyperlipidemic rats. Methods: The hypolipidemic action of T. chebula has been studied in normal rats and in atherogenic (cholesterol containing) diet induced hyperlipidemic albino rats. Results: In atherogenic diet induced hyperlipidemic model, the rats receiving alcoholic extract of immature (IMF), mature (MF) fruits and ethyl acetate soluble fraction (immature fruits) of T. chebula treatment showed marked reduction in total cholesterol (TC) (p<0.05), total triglyceride (TG) (p<0.001), total protein (TP) (p<0.001) and elevation in high density lipoprotein cholesterol (HDL-C) (p<0.001). In normocholesterolemic model, the feeding of ethanolic extract (immature fruits) lowered the levels of TC, TG, TP and increased level of HDL-C. Conclusions: The ethanolic extract and ethyl acetate fraction were found to possess significant hypolipidemic activity. The most active extract of T. chebula is ethyl acetate fraction of immature fruits, which was able to bring high serum lipid to normal level. The present study brings forth the efficacy of < as a hypolipidemic agent.Keywords
Terminalia chebula, Hypolipidemic Activity, Cholesterol, Triglyceride- Antioxidant and Hepatoprotective Activity of Root extract of Baliospermum montanum (Willd) Muell Arg
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Authors
B. Ahirwar
1,
D. Ahirwar
2
Affiliations
1 Institute of Pharmacy, Guru Ghasidas University, Bilaspur (C.G.), IN
2 School of Pharmacy, Chouksey Engineering College, Bilaspur (CG), IN
1 Institute of Pharmacy, Guru Ghasidas University, Bilaspur (C.G.), IN
2 School of Pharmacy, Chouksey Engineering College, Bilaspur (CG), IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2705-2711Abstract
The hydroalcoholic extract of Baliospermum montanum Muell Arg ischolar_main was screened for their possible hepatoprotective and antioxidant effect. Carbon tetrachloride (CCl4) and ethanol were used to produce liver toxicity. The hydroalcoholic extract of plant ischolar_main was administered and biochemical parameters were estimated. Concurrently, silymarin was used as a standard hepatoprotective agent. The ischolar_main extract was also studied for in vitro total antioxidant capacity by ABTS assay. The results indicated that biochemical parameter changes produced by CCL4 and ethanol were restored to normal by the hydroalcoholic extract. The hydroalcoholic extract showed significant (p<0.05) protection of liver cell against CCL4 and ethanol-induced hepatocellular injury in a dose-dependent manner. The effects of hydroalcoholic extract were comparable with silymarin. Hepatoprotection produced by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation. The antioxidant potential of the extract may be attributed to the presence of phenolic and flavonoid compounds. The ischolar_main extract of Baliospermum montanum Muell Arg. exhibited significant antioxidant and hepatoprotective activity.Keywords
Antioxidants Activity, Ethanol, Hepatoprotective Activity, Baliospermum montanum Muell Arg.References
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