A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Jayakar, B.
- Anti-ulcer Effect of Bauhinia variegata Linn. in Rats
Authors
Source
Journal of Natural Remedies, Vol 3, No 2 (2003), Pagination: 215-217Abstract
Objective: To evaluate the ulcer protective effect of alcoholic extract of Bauhinia variegata in rats. Materials and methods: The anti-ulcer activity of alcoholic extract of B. variegata was evaluated against gastric ulcer induced by pyloric ligation and aspirin induced ulcer model in rats. The stomach was incised along with greater curvature and examined for ulcer. Effect of alcoholic extract of B.variegata on volume of gastric secretion, total, free acidity and ulcer index in pylorus ligated and aspirin induced ulcer rat was determined. Results: Oral administration of alcoholic extract of B. variegata decreased the volume of gastric secretion, total, free acidity and ulcer index with respect to control. Conclusion: The alcoholic extract of B. variegata possesses significant (P< 0.001) ulcer protective activity.Keywords
Anti-ulcer, Bauhinia variegata, Pyloric Ligation, AspirinFull Text
- Absorption Correction Method for Estimation of Amlodipine Besylate and Olmesartan Medoxomil in Combined Tablet Dosage Form
Authors
1 Vinayaka Mission College of Pharmacy, Salem-636008, Tamilnadu, IN
2 SRM College of Pharmacy, Kattankulathur-603203, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 7 (2011), Pagination: 1100-1102Abstract
A new, simple, accurate and sensitive UV - spectrophotometric absorption correction method has been developed for simultaneous determination of amlodipine besylate and olmesartan medoxomil in combined tablet dosage form. Methanol and distilled water were used as solvents. The wavelengths selected for the analysis were 363nm and 258 nm for amlodipine besylate and olmesartan medoxomil, respectively. Beer's law obeyed the concentration range of 1.25- 6.25 μg/ ml and 5 - 25 μg/ml for amlodipine besylate and olmesartan medoxomil respectively. The method was validated stastically.
Keywords
Amlodipine Besylate, Olmesartan Medoxomil, Absorption Correction Method, ICH Guidelines.
- Antitumor Activity and Antioxidant Role of Ethanolic Extract of Pseudarthria viscida Linn against Ehrlich Ascites Carcinoma
Authors
1 JKK Nataraja College of Pharmacy, Komarapalayam, Namakkal District, Tamil Nadu 638183, IN
2 Nandha College of Pharmacy, Erode, Tamil Nadu 638 052, IN
3 Department of Pharmaceutics, Seventh of April University, Al-Zawia City, LY
4 Vinayaka Missions College of Pharmacy, Salem, Tamil Nadu, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 110-113Abstract
The study was aimed at evaluating the antitumor and antioxidant activities of ethanol extract of Pseudarthria viscida (Family: Fabaceae) against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The ethanol extract of Pseudarthria viscida (EEPV) was administered at the doses of 100 and 200 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of EEPV on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters were estimated. Treatment with EEPV decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of EEPV decreases the level of lipid peroxidation and protein content and significantly increased the level of antioxidant enzymes such as Catalase (CAT), Glutathione (GSH) and Superoxide dismutase (SOD). These observations are suggestive of the protective effect of EEPV against Ehrlich Ascites Carcinoma (EAC).