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Jayalakshmi, B.
- Synthesis And Biological Evaluation of New S-Mannich Bases of 3-Methyl-4-Phenyl-3,4,5,6,7,8, Hexahydroquinazoline-2(1h)-Thione
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, JKKMMRF College of Pharmacy, B. Komarapalayam, Namakkal, Tamil Nadu – 638 183, IN
1 Department of Pharmaceutical Chemistry, JKKMMRF College of Pharmacy, B. Komarapalayam, Namakkal, Tamil Nadu – 638 183, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1573-1577Abstract
The chalcone was synthesized from cyclohexanone and an aromatic aldehyde by aldol condensation reaction, followed by cyclisation with thiourea results in hexahydro quinazoline. The third position is methylated by using methyl iodide, finally the mannich reaction was carried out with five different amines at second position of the hexahydro quinazoline to get five different S-Mannich bases. All the 5 synthesized new compounds were studied for their physiochemical characters. And their structures were confirmed by spectral studies (IR, NMR). These new derivatives were evaluated for analgesic and anti-inflammatory activity.
Keywords
S-Mannich Bases, Quinazoline, Chalcone.
- Simultaneous Estimation of Montelukast Sodium and Levocetrizine Hydrochloride by UV-Visible Spectrometry
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Authors
Affiliations
1 Department of Pharmaceutical Analysis, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam 638 183, Namakkal (DT), Tamilnadu, IN
1 Department of Pharmaceutical Analysis, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam 638 183, Namakkal (DT), Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 104-109Abstract
Two methods for simultaneous estimation of Montelukast sodium and Levocetrizine HCl in two component solid dosage forms have been developed. The methods employ the application of absorption corrected for interference, the first order derivative method. All these methods utilize methanol as a solvent. In absorption corrected for interference method montelukast sodium shows maximum absorption at a wavelength of 280.2 nm ,and levocetrizine HCl at 232.2 nm, where the linearity ranges for both the drugs were 5-30 μg/ml. At the wavelength of montelukast sodium levocetrizine HCl shows zero absorbance but at the wavelength of levocetrizine HCl, montelukast sodium shows some absorbance from this method the amount of montelukast sodium were determined at 280.2 nm, while at the wavelength of levocetrizine HCl we get the total absorption of both the drug, the amount of levocetrizine HCl were determined by applying the absorption corrected for interference method. In First order derivative method, the absorbance values at 270.8 nm and 224 nm of first derivative spectrum was used for the estimation of montelukast sodium and levocetrizine HCl respectively without mutual interference. This method obeyed Beers law in the concentration range of 10-60 μg / ml for montelukast sodium and 10-35 μg / ml for levocetrizine HCl, the results of analysis of both method have been validated statistically and recovery studies confirmed the accuracy of the proposed method.
Keywords
Montelukast, Levocetrizin, and UV.- Simultaneous Estimation of Nitazoxanide and Ofloxacin by RP-HPLC Method
Abstract Views :176 |
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Authors
Affiliations
1 Department of Pharmaceutical Analysis, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam-638183, Namakkal (DT), Tamilnadu, IN
1 Department of Pharmaceutical Analysis, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam-638183, Namakkal (DT), Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 1062-1064Abstract
The present paper deals with the development of RP-HPLC method for the determination of Nitazoxanide and Ofloxacin in bulk and in formulation using UV detector. Selected mobile phase was a combination of 0.005 M tetra butyl ammonium hydrogen sulphate and acetonitrile in the ratio of 45:55 and the wavelength selected was 240 nm. The flow rate 1.0 ml/min, and the injection volume was 20 μl. The sepration was performed at ambient temperature. Retention time of Nitazoxanide and Ofloxacin was found to be 6.051and 2.106. Linearity of the method was found to be 400 to 600 mcg/ml and 160 to 240 mcg/ml for Nitazoxanide and Ofloxacin respectively. Accuracy of the method was determined through recovery studies by adding known quantities of standard drug to the pre analyzed test solution and was found to be 99.08-99.81% and 100.18-100.65% for Nitazoxanide and Ofloxacin respectively. This method was validated according to ICH guidelines.Keywords
Nitazoxanide, Ofloxacin and RP-HPLC.- Simultaneous Estimation of Montelukast Sodium and Levocetrizine Hydrochloride by RP-HPLC Method
Abstract Views :178 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Analysis, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam-638183, Namakkal (DT), Tamilnadu, IN
1 Department of Pharmaceutical Analysis, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam-638183, Namakkal (DT), Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 1069-1072Abstract
The present paper deals with the development of RP-HPLC method for the determination of montelukast sodium and levocetrizin hydrochloride in bulk and in formulation using UV detector. Selected mobile phase was a combination of acetonitril, methonal, and water (40:40:20) and the wavelength selected was 232 nm. The flow rate was kept at 1 ml/min, and the injection volume was 20 μl. The separation was performed at ambient temperature. Retention time of montelukast sodium was 11.81 min and for levocetrizine hydrochloride was 6.01 min. Linearity of the method was found to be 0.030 to 0.060 mg/ml for montelukast sodium and 0.030 to 0.060 mg/ml for levocetrizine hydrochloride with the regression coefficient of 0.991 and 0.994 for montelukast sodium and levocetrizine hydrochloride respectively. This method was validated according to ICH guidelines.Keywords
Montelukast, Levocetrizin and RP-HPLC.- A Statistical Analysis of the Impact of Farmer Producer Company (FPC) on Coconut Farmers in Coimbatore District
Abstract Views :355 |
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Authors
Affiliations
1 Department of Physical Sciences and Information Technology, Tamil Nadu Agricultural University, Coimbatore (T.N.), IN
1 Department of Physical Sciences and Information Technology, Tamil Nadu Agricultural University, Coimbatore (T.N.), IN
Source
International Research Journal of Agricultural Economics and Statistics, Vol 9, No 2 (2018), Pagination: 305-312Abstract
The Farmer Producer Company (FPC) can serve as a potential alternative to improve the socio-economic condition of the farmers. The present study was conducted with Velliangiri Uzhavan Producer Company Limited (VUPCL), located at Thondamuthur block in Coimbatore district. The primary data were collected through personal interview from 50 members and 50 non-members of selected Farmer Producer Company (FPC). The study revealed that membership in the company directly affected the socio-economic conditions of the coconut farmers in the study area. Using various statistical techniques it was found that members of the Farmer Producer Company (FPC) were highly benefitted compared to non-members of the company. A significant difference between the members and non-members was also observed in terms of socio-economic conditions.Keywords
FPC, VUPCL, Statistical Techniques, Socio-Economic Conditions.References
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- Moser, Lisa Weissenburger, Jane, Meza, Fang, Yu, Oyewale Shiyanbola, Debra J. Romberger and Tricia, D. Levan (2016). A principal factor analysis to characterize agricultural exposures among Nebraska veterans. J. Exposure Sci. & Environ. Epidemiol., 1-7.
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- Subhashree, Sahu, Sharma, J.P. and Burman, R.R. (2017). Socio-economic impact assessment of farms produce promotion society (FAPROS) of Punjab. Indian Res. J. Extn. Edu., 17 (1): 13-17.
- Susan, Kaaria, Martha, Osorio, Sophie, Wagner and Ambra, Gallina (2016). Rural women’s participation in producer organizations: An analysis of the barriers that women face and strategies to foster equitable and effective participation. J. Gender, Agric. & Food Security, 1 (2): 148-167.
- Trebbin, A. and Hassler (2012). Farmers’ producer companies in India: a new concept for collective action, Environment & Planning, 44: 411-427.
- Yamuna, S.M. and Ramya, R. (2016). Study of coconut cultivation and marketing in Pollachi taluk. Internat. J. Innovative Res. Medical Sci., 1(2): 2455-7188.
- Parasar, Rohit (2016). Micro level case study of producer companies,www.mse.ac.in/wp-content/uploads/2016/10/Rohit-Parasar.pdf
- Registration and Regulatory Requirements of Generic Drugs Marketing Authorization in “BRICS” Countries
Abstract Views :166 |
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Authors
Affiliations
1 Department of Pharmaceutical Regulatory Affairs, SRM Institute of Science and Technology, SRM College of Pharmacy, Kattankulathur-603203 Dist–Kancheepuram, IN
1 Department of Pharmaceutical Regulatory Affairs, SRM Institute of Science and Technology, SRM College of Pharmacy, Kattankulathur-603203 Dist–Kancheepuram, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 3 (2019), Pagination: 1403-1408Abstract
The comparative study of generic drug registration in BRICS, was to find out the differences among the guidelines. “BRICS” mainly refers to Brazil, Russia, India, china and South Africa. The regulatory requirements of each country is different from each other, “BRICS” has the fastest growing and largest emerging markets which shows the positive growth in the pharmaceutical companies. The medical regulatory system in the BRICS countries is increasing in the medical profession to safeguard and promote the medicine. The BRICS countries together is consider as important emerging economics, which has 40% of world population. To develop the universal health coverage, The BRICS countries of national institution agreed to join hands with (WHO), world health organization.Keywords
Regulatory Requirements, Registration Process, Brazil, Russia, India, China and South Africa (BRICS), Generic Products.References
- Marketing Authorization Available from: http://en.wikipedia.org/ wiki/Marketing authorization
- Brazilian National Health Vigilance Sanitaria Available from:
- http://www.ghtf.org/meetings/conferences/9thconference/presentations/latinamerican/waynebrodbeskow.pdf
- National Health Surveillance Agency: http://www.anvisa.gov.br/hotsite/genericos/legis/leis/6360_e.htm
- National Health Surveillance Agency: Resolution no nº 3.675 http://www.anvisa.gov.br/eng/legis/resol/136_03_ redc_e.htm
- National Health Surveillance Agency: http://www.puntofocal.gov.ar/notificotros_miembros/bra226_t.pdf
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- G. Sai Hanuja, B. Sai Kumari, M. V. Nagabhushanam, D. Nagarjuna Reddy, Brahmaiah Bonthagarala, Regulatory Requirements for Registration of Generic Drugs in “BRICS” Countries, International Journal of Pharmaceutical Science and Health Care, ISSN 2249 – 5738, Issue 6, Vol. 6, November-December 2016,20-40.
- B. Sai Kumari, G. Sai Hanuja, M.V. Nagabhushanam, D. Nagarjuna Reddy, Brahmaiah Bonthagarala, Current Regulatory Requirements for Registration of Medicines, Compilation and Submission of Dossier in Australian Therapeutic goods Administration, International Journal of Advanced Scientific and Technical Research ISSN 2249-9954, Issue 6 volume 6, November-December 2016, 144-157. 15.Shaik Salman Basha, S. M. Shakeel, M. V. Nagabhushanam, D. Nagarjuna Reddy, Brahmaiah Bonthagarala, The Assessment of Current Regulatory Guidelines for Biosimilars- A Global Scenario, World Journal of Pharmaceutical Research, ISSN 2277– 7105, volume 6, Issue 1, 351-369.
- S.M. Shakeel, Shaik Salman Basha, M.V. Nagabhushanam, D. Nagarjuna Reddy, Brahmaiah Bonthagarala, Comparison of Regulatory Requirements for Generic Drugs Dossier Submission in United States and Canada, International Journal of Pharmaceutical Science and Health Care, ISSN 2249 – 5738, Issue 6,Vol. 6 , November-December 2016, 1-19.
- Mounica N.V.N., Sharmila Reddy V, Anusha S, Evangeline L, Nagabhushanam M.V., Nagarjunareddy D, Brahmaiah B, Scale up and Post Approval Changes (SUPAC) Guidance for Industry: A Regulatory Note, ISSN: 2321 – 6794, DOI:https://doi.org/10. 22270/ijdra.v5i1.192, International Journal of Drug Regulatory Affairs; 2017, 5(1), 13-19.
- Sharmila Reddy V, Mounica N.V.N., Anusha S, Evangeline L, Nagabhushanam M.V., Nagarjunareddy D, Brahmaiah B, Regulatory Requirements of Similar Biologics for Marketing Authorization in India, ISSN: 2321–6794, DOI:https://doi.org /10.22270/ijdra.v5i1.193, International Journal of Drug Regulatory Affairs; 2017, 5(1), 20-24.