Informatics Publishing Limited

M. S. Saluja ¹, B. Sangameswaran ², A. Sharma ³, C. Dubey ³

Affiliations
1 Department of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, Rajasthan, IN
2 Department of Pharmacognosy, SRM University, Chennai, Tamilnadu, IN
3 Department of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, IN

Abstract

Present study was performed to explore the cytotoxic activity of various concentration (10- 200ug/ml) of Acetonic and 50% ethanolic Extract from the leaves of Cinnamomum tammala linn Against EAC and DAL cell lines using Trypan Blue method and to find out the phytoconsituents presented in leaves. Results found that both of extracts exhibited significant cytotoxity activity at 200ug/ml, but higher cytotoxic activity was found in acetonic extract.

Keywords

Cytotoxic Activity, Cinnamomum tammala Linn. Ehrlich Ascites Carcinoma (EAC) and Dalton’s Ascitic Lymphoma (DAL).

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V. H. Bhaskar ¹, M. Kumar ², B. R. Balakrishnan ², B. Sangameswaran ²

Affiliations
1 M.P. Patel College of Pharmacy, Kapadwanji, Gujarat-3876202, IN
2 Medicinal Plant Research Centre, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem-636008, Tamil Nadu, IN

Abstract

Certain (2E)-substituted-2-ethylidene-5,6-diphenylimidazo[2,1-b][1,3]thiazol-3-(2H)-ones (4a-f) have been synthesized by the condensation of 4,5-diphenylimidazoin-2-thiones (3) with different aromatic aldehydes and chloroacetic acid in presence of acetic anhydride, anhydrous sodium acetate and glacial acetic acid. These compounds were characterized by their analytical and spectral data. The title compounds were found to be efficient antibacterial agents on evaluation.

Keywords

Imidazothiazole, Biological Activity, Antibacterial Activity.

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