Informatics Publishing Limited

T. Ramanji Reddy , P. Ravi , B. V. R. Krishna , D. Padmavathi , Ch. Ajay Babu

Abstract

Prosolve, a new directly compressible vehicle consists of microcrystalline cellulose (98%) and colloidal silicon dioxide (2%). Piroxicam (20 mg) tablets, celecoxib (100 mg) tablets and aceclofenac (100 mg) tablets were formulated employing prosolve and three super disintegrants namely pregelatinised starch, sodium starch glycolate and croscarmellose sodium by direct compression method with a view to enhance their dissolution rate. In the micromeritic evaluation microcrystalline cellulose and its blends with other tablet ingredients exhibited excellent to good flow needed for direct compression. All the tablets formulated employing prosolve fulfilled the Pharmacopoeial standards with regard to various tablet characters. These tablets also gave 2 to 5 fold increase in the dissolution rate when compared to commercial tablets. Among the three disintegrants sodium starch glycolate gave higher dissolution rates when compared with both pregelatinised starch and croscarmellose sodium.

Keywords

Prosolve, Piroxicam, Celecoxib, Aceclofenac and Direct Compression Method.

Full Text

   

Ch. Ajay Babu , M. Prasada Rao , J. Vijaya Ratna

Abstract

Conventional drug delivery systems have little control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the process of osmosis. Osmotic devices are the most promising strategy based systems for controlled drug delivery. They are the most reliable controlled drug delivery systems and could be employed as oral drug delivery systems. The present review is concerned with the study of drug release systems which are tablets coated with walls of controlled porosity. When these systems are exposed to water, low levels of water soluble additive is leached from polymeric material i.e. semipermeable membrane and drug releases in a controlled manner over an extended period of time. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. In this paper, various types of osmotically controlled drug delivery systems and the basic components of controlled porosity osmotic pump tablets have been discussed briefly.

Keywords

Osmotic Pump, Controlled - Porosity Osmotic Pump Tablet, Semipermeable Membrane, Osmogent, Leachable Pore Formers.

Full Text