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Raju, D.
- Evaluation of Antitussive Activity of Alternanthera sessilis
Abstract Views :237 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacology, SRM College of Pharmacy, Kattankulathur, Kancheepuram Dt, Tamil Nadu-603319, IN
1 Department of Pharmacology, SRM College of Pharmacy, Kattankulathur, Kancheepuram Dt, Tamil Nadu-603319, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 4 (2012), Pagination: 233-235Abstract
The aim of the present study was to look at the antitussive activity of the ethanol extract of Alternanthera sessilis whole plant (EAS) by Sulfur dioxide gas induce model in mice. Results were revealed that the MESI was found to produce significant antitussive activity when compared with control and codeine phosphate in a dose dependent manner. The EAS produced 51.1 and 29.2% inhibition of SO2 induced cough at doses of 250 and 500mg/kg respectively the standard antitussive drug codeine phosphate(10 and 20mg/kg.p.o) showed 45.2 and 25.3 % inhibition respectively.Keywords
Alternanthera sessilis, Antitussive Activity, Sulfur Dioxide Gas Induce Model in Mice.
References
- Tripathi KD. Essentials of Medical Pharmacology. Jaypee Brothers, New Delhi, 1999; 4th edt: p.222.
- Goodman and Gillman's. The Pharmacological Basis of Therapeutics, McGraw-Hill, , 2005; 11th edt: p. 578.
- Sutovska M, Nosalova G, Franova S and Kardosova A. The antitussive activity of polysaccharides from Althaea officinalis, Arctium lappa and Prunus persica. Bratisl Lek Listy. 108 (2); 2007: 93-99.
- The Wealth of India. Raw materials, Vol 1(Revised), CSIR, New Delhi, 1985; 318-9. 5. Rastogi RP, Compendium of Indian medicinal plant, CDRI, Lucknow, 1993; 9th edt: p. 1970-9.
- Gupta AK. Indian medicinal plants, ICMR, New Delhi, 2004; 151-7.
- Sinha P, Arora VK, Wahi SP. Chemical investigation on Alternanthera sessilis. Indian Drug. 1; 1984: 139-40.
- Anandkumar BH, Sachidanand YN. Treatment of acne vulgaris with new polyherbal formulation clarina cream. Indian J Dermatol. 46; 2001: 1-3.
- Archana Borah, Yadav RNS and Unni BG. In vitro antioxidant and free radical scavenging activity of Alternanthera sessilis. IJPSR. 2 (6); 2011: 1502-1506
- Jalapue SS, Agarwal N, Patil MB, Chimkode R and Tripathi A. Antimicrobial and wound healing activities of leaves of Alternanthera sessilis. Int J Green Pharm. 2; 2008: 141-4.
- Srinivas Reddy C, Subhashini T and Krishnaveni B. Anti- Inflammatory Activity of Leaf Extracts of Alternanthera sessilis. Hygeia J D Med. 2(1); 2010: 54-57. Anand Sankar, Nikhila C, Lakshmiprasanna VC, Mobeena SK, Karunakar Kand Bharathi N. Evaluation of antitussive activity of Rosa centifolia. IJPSR. 2 (6); 2011: 1473-1475.
- Synthesis, Characterization and Pharmacological Evaluation of Ester Prodrugs of Naproxen
Abstract Views :190 |
PDF Views:80
Authors
V. Sai Saraswathi
1,
D. Saravanan
2,
J. Padmavathy
2,
I. Aparna Lakshmi
2,
D. Raju
3,
Ch. Praveen kumar
2,
C. R. Prakash
4
Affiliations
1 Vellore Institute of Technology, Vellore – 632 007, Tamil Nadu, IN
2 Ratnam Institute of Pharmacy, Pidathapolur, Nellore – 524 346, Andhra Pradesh, IN
3 SRM College of Pharmacy, SRM University, Kattankulathur, Chennai-603203, TamilNadu, IN
4 DCRN College of Pharmacy, Ilkollu, Andhra Pradesh, IN
1 Vellore Institute of Technology, Vellore – 632 007, Tamil Nadu, IN
2 Ratnam Institute of Pharmacy, Pidathapolur, Nellore – 524 346, Andhra Pradesh, IN
3 SRM College of Pharmacy, SRM University, Kattankulathur, Chennai-603203, TamilNadu, IN
4 DCRN College of Pharmacy, Ilkollu, Andhra Pradesh, IN
Source
Journal of Pharmaceutical Research, Vol 10, No 4 (2011), Pagination: 149-153Abstract
Naproxen suffers from the general side effects of NSAIDs, owing to presence of free carboxylic acid group. The study aimed to retard the adverse effects of gastrointestinal origin. Ten prodrugs of Naproxen were synthesized by amidation with N-Substituted-2-chloroacetamide. Purified synthesized prodrugs were characterized by their M.P., TLC, IR, 1H NMR, MS and elemental analysis. The purity of the synthesized prodrugs was monitored by HPLC. Synthesized prodrugs were subjected to acute oral toxicity studies, anti-inflammatory activity and reduced ulcerogenic activity. Marked reduction of ulcerogenic activity and anti-inflammatory activities were obtained in all cases as compared to Naproxen. Among synthesized prodrugs, viz. A-5, A-6 and A-8 showed significant anti-inflammatory activity and A-2 and A-5 showed reduced ulcerogenic activity compared to Naproxen. In acute oral toxicity studies, all synthesized prodrugs were found to be non toxic at dose of 2000 mg/kg.Keywords
Naproxen, Prodrugs, Glycolamide Ester Conjugates, Characterization, Pharmacological Activity.Full Text
- Hepatoprotective Activity of Vitex quinata Roots against Paracetamol-Induced Hepatic Injury in Rats
Abstract Views :184 |
PDF Views:0
Authors
V. Sreedhar
1,
L. K. Ravindra Nath
2,
N. Madana Gopal
3,
K. Venu Gopal
4,
D. Raju
3,
K. K. Rajasekhar
5
Affiliations
1 Deparment of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, IN
2 Department of Chemistry, Srikrishna Devaraya University, Anantapur, A.P, IN
3 Department of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, IN
4 Dept of Pharmacy, Nirmala College of Pharmacy, Kadapa, A.P, IN
5 Departement of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi-517503, A.P, IN
1 Deparment of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, IN
2 Department of Chemistry, Srikrishna Devaraya University, Anantapur, A.P, IN
3 Department of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, IN
4 Dept of Pharmacy, Nirmala College of Pharmacy, Kadapa, A.P, IN
5 Departement of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi-517503, A.P, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 2 (2011), Pagination: 77-81Abstract
Methanolic extracts of Vitex quinata ischolar_mains at 200, 400 and 800 mg/kg and silymarin was prepared and tested for its hepatoprotective effect against paracetamol induced hepatitis in rats. Alteration in the level of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, TPL, CHL, TPTN and ALP were tested in both treated and untreated groups. The methanolic extracts of Vitex quinata ischolar_mains at 200,400 and 800 mg/kg and silymarin showed a significant (P<0.05) decrease in all the elevated SGOT, SGPT, ALKP, TBL, CHL and significant increase (P<0.05) in TPTN and ALB levels produced by the toxicant Paracetamol.