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Pinkaew, Decha
- Ant-altherogenic Effects of Morelloflavone from Garcinia dulcis Leaves in Cholesterol Fed Rabbits
Authors
Source
Journal of Natural Remedies, Vol 8, No 2 (2008), Pagination: 151-159Abstract
A biflavonoid, morelloflavone isolated from leaves of Garcinia dulcis Kurz was investigated for its ability to reduce plasma lipids and prevent progression of atherosclerotic lesions in hypercholesterolemic rabbits. Male rabbits were divided into 6 groups. Group 1 received a regular diet, Group 2 received a regular diet with 0.02% (w/w) of G. dulcis derived morelloflavone, Group 3 was fed a diet containing 1% (w/w) cholesterol to induce hypercholesterolemia, and Group 4 to Group 6 had their 1% cholesterol diets supplemented with morelloflavone at concentrations of 0.005%, 0.01% and 0.02%, respectively. During a 4 month-experimental period, rabbits were monitored for their body weights and plasma cholesterol, triglycerides and thiobarbituric acid-reactive substances (TBARS) levels monthly and the extent of aortic atherosclerotic lesions were analysed at the end of the period. The levels of plasma cholesterol, triglycerides and TBARS as well as intimal thickening within aortas were increased in all animals fed with cholesterol diets. Such increases, however, were reduced in the presence of morelloflavone. The concentrations of morelloflavone that showed inhibitory effects in all cases were 0.005% and 0.01%, whereas the 0.02% dosage was ineffective.Keywords
Atherosclerosis, Atherosclerotic Lesion, Garcinia dulcis, Hypercholesterolemic Rabbit, Hypolipidemic Effect, Morelloflavone- Improved WOMAC Score Following Treatment with Nanoparticle Phyllanthus Amarus Phonophoresis Gel for Knee Osteoarthritis
Authors
1 Department of Physical Therapy, Chiang Mai University, Chiang Mai, TH
2 Department of Pharmaceutical Sciences,Chiang Mai University, Chiang Mai, TH
3 Department of Community Medicine, Chiang Mai University, Chiang Mai, TH
Source
Indian Journal of Public Health Research & Development, Vol 10, No 12 (2019), Pagination: 1623-1628Abstract
Objective: The aim of this study is to compare the effects of phonophoresis of nanoparticle Phyllanthus amarus phonophoresis gel (PP) and ultrasound therapy (US) in patients with osteoarthritis of knee (OA).
Method: OA knee patients (n=40) who had symptomatic knee pain were randomly allocated into 2 groups. There are US group (ultrasound group) and PP group (Phyllanthus amarus gel phonopheresis group)(20 in each group) were treated with an ultrasound program by using continuous mode, 1.0 W/cm2, 10 minutes per session, once daily and10 sessions. The nanoparticle Phyllanthus amarus gel was used in the PP group, while the US group was use the nondrug coupling gel. Pain and function assessment were measured by the visual analog scale (VAS) and the Western Ontario and McMaster Universities O-osteoarthritis Index (WOMAC), respectively.Moreover, the range of motion was used to measureby goniometers. Three primary outcomes were investigated before and after treatment 10 sessions.
Results: The VAS and total WOMAC scores were significantly increasedpost-treatment in both groups (P < 0.001). The PP group showed more significant improve VAS and total WOMAC scores than the US group (P<.001). However, ROM was not significant in both groups to compare to baseline.
Conclusion: The nanoparticle Phyllanthus amarus phonophoresis gelwas significantly reduced pain and improve knee functioning. Itis suggested as a new, effective method for treatment OA knee for relieving pain and improving function.