Informatics Publishing Limited

Deepa Thakur , C. R. Mukundan

Abstract

Hemispheric lateralization was assessed in schizophrenics and manics using dichotic listening tasks. The sample consisted of 113 schizophrenics, 11 manics and 20 normals. Laterality indices were determined for each of the three groups. Schizophrenics had a significant left ear advantage and mancis had a significant right ear advantage. As expected, the normals had a significant right ear advantage. The left ear advantage seen in schizophrenics may be an indication of a left hemisphere dysfunction. No definite evidence of a lateralized hemispheric dysfunction emerged with respect to the manics.

Keywords

Dichotic Listening, Lateralized Hemispheric Dysfunction, Schizophrenia, Manic Psychosis

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Hemant Badwaik ¹, S. Venkataraman ², Deepa Thakur ¹, Minu Vinod ¹, J. Raamamurthy ¹, Kiran Deshmukh ²

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), IN
2 K.M. College of Pharmacy, Madurai (T.N), IN

Abstract

Acetanilide was cyclized via Vilsmeier-Haack reagent to give 2- chloro -3- formyl quinoline. The aldehydic group was protected to prevent the preferential attack of nitrogen nucleophiles. The protection of aldehydic group in the present system was achieved with ethylene glycol to afford dioxolan derivative. Dioxolan derivative treated with nitro substituted phenyl hydrazine in alcoholic solution followed by deprotection of aldehydic group afforded the 2-(2-(2- nitrophenyl) hydrazinyl) quinoline-3-carbaldehyde and 2-(2-(2, 4-dinitrophenyl) hydrazinyl) quinoline-3- carbaldehyde. The synthesized derivatives were screened for antimicrobial activity.

Keywords

Vilsmeier–Haack Reagent, Dioxolan, 2-(2-(2, 4-Dinitrophenyl) Hydrazinyl) Quinoline-3- Carbaldehyde, Antimicrobial Agent.

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Suresh Rajput ¹, Dharamveer Sisodia ¹, Hemant Badwaik ², Deepa Thakur ², Kushagra Nagori ²

Affiliations
1 Ultra College of Pharmacy, Madurai (T.N), IN
2 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), IN

Abstract

A novel 5(4-(4-substituted)Aminobenzylidine)thiazolidine-2,4-dione derivatives were synthesized and characterized by IR and H-NMR spectral analysis. Antibacterial and antifungal activities of the compounds were assessed by in vitro growth inhibitory activity against Escherichia coli, Staphylococcus aureus, Asperigillus niger, Candida albicans by using the disc diffusion method. Most of all compounds exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli, while weak antifungal activity against Asperigillus niger and Candida albicans.

Keywords

Thiazolidine-2,4-dione, Antibacterial and Antifungal Activity, Disc Diffusion Method.

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