Informatics Publishing Limited

Devi Prasad Mandal ¹, Neeta Mohanty ¹

Affiliations
1 Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

Head and neck squamous cell carcinoma are usually associated with multiple premalignant lesions. This is derived from the idea of field effect in cancer. The concept of “FIELD CANCERIZATION” was introduced by Slaughter et al in 1953 while studying the presence of histologically altered tissue adjacent to oral squamous cell carcinoma (OSCC) cases. It explains the initiation of several primary tumours and locally recurrent cancer. Advance technology and cautious study design using suitable control is helpful in detection of important molecular biomarkers in genetically transmuted but histologically normal cells. These tumor specific biomarkers should improve clinical implications and effectiveness in early diagnosis and treatment modalities. In this review we discuss the perception, clinical implications and effectiveness of field cancerization in head and neck squamous cell carcinoma.

Keywords

Field Cancerization, Head and Neck Squamous Cell Carcinoma.

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Devi Prasad Mandal ¹, Neeta Mohanty ²

Affiliations
1 Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Oral & Maxillofacial Pathology & Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

Adenoid cystic carcinoma is an uncommon salivary gland tumor with high rate of recurrence and metastasis. The unpredicted clinical course is countered-back by regular clinical follow-up for at least >15 years. The traditional treatment protocol is surgery with postoperative radiotherapy to optimize local metastasis. Research has been carried out to understand the molecular biological process of the tumor that can cure the patients at high risk of recurrence. This article presents a case of sub-mandibular gland malignant neoplasm of a 34 years male patient.

Keywords

Adenoid Cystic Carcinoma (ACC), Salivary Gland Neoplasm.

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