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Authors
Affiliations
1 Department of Pharmacology & Toxicology, College of Veterinary Science, Hyderabad-500030, IN
2 Assistant professor, Dept. of Pharmacology & Toxicology, College of Veterinary Science, Tirupati -517 502, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 16, No 1 (2009), Pagination: 63-68
Abstract
A study was conducted on poultry to evaluate the oxidative stress due to ochratoxin and T-2 either alone or in combination. Broiler chicks were fed OTA @2ppm,T-2 @ 1ppm, Zingiber officinale (rhizome shade dried and powdered @ 0.5%, Curcuma longa rhizome @ 0.5%, toxichek @ 0.1% and activated charcoal @ 0.4% in feed in combinations of 20 groups. The study revealed a significant (p<0.05) increase in the activities of glutathione peroxidase, glutathione reductase, catalase and TBARS in toxic groups (OTA, T-2 and OTA+T-2). Results of the present study suggest that OTA and T-2 either alone or in combination induce oxidative stress and supplementation of Curcuma longa, Zingiber officinale, toxichek and activated charcoal in order showed amelioration by stabilizing the antioxidant defenses.
Keywords
Activated charcoal (AC), ochratoxin (OTA), trichothecene (T-2)
