Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Chakravarthi, G.
- Evaluation of Anti-depressant Activity of Methanolic Seed Extract of Avena Sativa L. in Mice
Abstract Views :372 |
PDF Views:2
Authors
Affiliations
1 K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
2 T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
3 College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela, IN
1 K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
2 T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
3 College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 4 (2013), Pagination: 212-217Abstract
The main objective of the study to evaluate the Anti-depressant activity of seeds extract of Avena sativa in Forced swim test (FST), Tail Suspension test (TST) and antagonism of Apomorphine induced hypothermia in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, glycosides, saponins, amino acids, gums and mucilage. MSEAS did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, MSEAS showed diminution of duration of immobility time in 100mg/kg but not in 200mg/kg. In antagonism of Apomorphine induced hypothermia model, Desipramine but not both doses of MSEAS significantly antagonised the Apomorphine induced hypothermia. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, MSEAS showed antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission and Antagonism of Apomorphine induced Hypothermia indicating, MSEAS was not acting through Adrenergic system.Keywords
avena Sativa, Antidepressant Activity, Forced Swim Test, Tail Suspension Test, Antagonising Apomorphine Induced Hypothermia
References
- Cheung, I.W.Y., Nakayama, S., Hsu, M.N.K., Samaranayaka, A.G.P., Li-Chan, E.C.Y. (2009). Angiotensin-I converting enzyme inhibitory activity of hydrolysates from oat (A. sativa) proteins by in silico and in vitro analyses. Journal of Agricultural and Food Chemistry, 57, 9234-9242.
- Danielle Ryan, Megan Kendall and Kevin Robards. (2007). Bioactivity of oats as it relates to cardiovascular disease. Nutrition Research Reviews, 20, 147–162. Dinesh Dhingra and Amandeep Sharma. (2006). “A review on antidepressant plants”. Natural Product Radiance, 5(2), 144-152.
- Galdino P M, Nascimento M.V.M, Sampaio B.L, Ferreira R.N, Paula J.R, Costa E.A. (2009). Antidepressant-like effect of Lafoensia pacari A. St.-Hil. ethanolic extract and fractions in mice. Journal of Ethnopharmacology, 124, 581–585.
- .Khandelwal KR. (2000). “Practical Pharmacognosy. Techniques and Experiments” Pune, Nirali Prakashan, 2, 149- 155.
- Khare C P. (2007). Indian Medicinal Plants an Illustrated Dictionary. Springer, 73-74.Kokate CK. (1994). “Practical Pharmacognosy”, New Delhi, Vallabh Prakashan, 4,110-111.
- Kulkarni S.K and Ashish Dhir. (2007). Effect of various classes of antidepressants in behavioral paradigms of despair. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31, 1248–1254.
- OECD 2001-Guideline on acute oral toxicity (AOT) Environmental health safety monograph series on testing and adjustment No.425.
- Ryan, D., Kendall, M., Robards, K. (2007). Bioactivity of oats as it relates to cardiovascular disease. Nutrition Research Reviews, 20, 147-162.
- Sanchez-Mateo C.C, Prado B, Rabanal R.M. (2002). Antidepressant effects of the methanol extract of several Hypericum species from the Canary Islands. Journal of Ethnopharmacology, 79, 119–127.
- Santosh P, Venugopl R, Nilakash A S, Kunjbihari S, Dr. Mangala L. (2011). Antidepressant Activity of methanolic extract of Passiflora foetida leaves in mice. Int J Pharm Pharm Sci, 3(1), 112-115.
- Santosh P, Venugopl R, Nilakash A S, Kunjbihari S, Dr. Mangala L. (2011). “Antidepressant activity of methanolic extract of Passiflora foetida leaves in mice”. Int J Pharm Pharm Sci, 3(1), 112-115.
- Shun C.W., Bligh, S.W.A., Chang, L.Z., Song, S.S., Zheng, T.W., Zhi, B.H., Crowder, J., Branford- White, C., Vella, C. (2008). Sulfated b-glucan derived from oat bran with potent anti-HIV activity. Journal of Agricultural and Food Chemistry, 56, 2624-2629.
- Singh Rudra Pratap, Jain Ritesh, Mishra Rahul, Tiwari Prasant. (2012). Anti depressant activity of Hydro alcoholic Extract of Zingiber officinale. International Research Journal of Pharmacy, 3 (2).
- Sudhakar Pemminati, Gopalakrishna H N, Ashok K Shenoy, Sudhanshu Sekhar Sahu, Shishir Mishra, Vinayak Meti, Nair Vinod. (2010). “Antidepressant activity of aqueous extract of fruits of Emblica officinalis in mice. Int J App Bio and Pharma Tech, 1(2), 449-454.
- Sur, R., Nigam, A., Grote, D., Liebel, F., Southall, M.D. (2009). Avenanthramides, polyphenols from oats, exhibit antiinflammatory and anti-itch activity. Archives of Dermatological Research, 300, 569-574.
- Trease G E, Evans MC. (1983). “Text book of Pharmacognosy” London, BailliareTindall, 12, 336.
- Anti Anti-obesity and Antihyperlipidemic Activity of Ougeinia oojeinensis (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals
Abstract Views :44 |
PDF Views:13
Authors
K. Jagadeeshwar
1,
R. Subhakara Raju
1,
G. Chakravarthi
1,
A. Rajasekhar Reddy
2,
G. S. N. Koteswara Rao
2,
Narender Malothu
1
Affiliations
1 KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, IN
2 Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra, IN
1 KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, IN
2 Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra, IN
Source
Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 545-554Abstract
The present study was planned to assess the anti-obesity efficacy of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Ougeinia oojeinensis (Roxb.) belonging to the family Fabaceae. The soxhlation method was employed to produce the extracts. Wistar rats were subjected to a high-fat diet for 40 days to induce obesity. Along with the high-fat diet, a standard drug Orlistat 50 mg/kg and various extracts of O. oojeinensis at 100 mg/kg and 200 mg/kg were administered for 40 days. The key markers like lipid profiles, SGOT, SGPT, glucose, body weight, food intake, body temperature, atherogenic index, coronary index, and weight of the organs were assessed. The anti-antioxidant properties like TBARS, GSH, GR, Gpx, SOD, and CAT were also estimated. The results revealed that O. oojeinensis with the doses 100 and 200 mg/kg showed significant Anti obese and hypolipidemic effects in rats fed with a high-fat diet.Keywords
Antihyperlipidemic Anti-Obesity, Antioxidant, Lipid Profile, O. oojeinensis.Full Text
References
- Obesity and overweight [Internet]. 2021. Available from: https://www.who.int/news-room/fact-sheets/ detail/obesity-and-overweight
- Zhao C, Castonguay TW. Effects of free access to sugar solutions on the control of energy intake, Food Rev Int. 2017; 33(2):105-22. https://doi.org/10.1080/87559129.2016.1149863
- Withrow D, Alter D. The economic burden of obesity worldwide: a systematic review of the direct costs of obesity. Obes Rev 2011; 12(2):131-41. https://doi.org/10.1111/j.1467-789X.2009.00712.x
- Naja F, Hwalla N, Itani L, Karam S, Sibai AM, Nasreddine L. A Western dietary pattern is associated with overweight and obesity in a national sample of Lebanese adolescents (13-19 years): a cross-sectional study. Br J Nutr. 2015; 114(11):1909-19. https://doi.org/10.1017/S0007114515003657
- Niemann B, Rohrbach S, Miller M, Newby D, Fuster V and Kovacic J. Oxidative stress and cardiovascular risk: obesity, diabetes, smoking, and pollution: Part 3 of a 3-Part Series. J Am Coll Cardiol. 2017; 70(2):230- 51. https://doi.org/10.1016/j.jacc.2017.05.043
- Khare CP. Indian herbal remedies. Rational western therapy, ayurvedic and other traditional usage, Botany. 2014.
- Sahu R, Dewangan D, Roy A and Namdev K. Antiinflammatory action of O. oojeinensis (Roxb.) Hochr. Bark by HRBC membrane stabilization. Res J Pharm Technol. 2008; 1(1):57-8.
- Samyal ML, Ahmed Z, Bhushan S. Overview of O. oojeinensis: Medicinal Plant. J Chem Pharm Sci. 2013; 6(2):73-7.
- Patwardhan S, Vadnal P, Kumar Singhai A, Somani R. Studies of hepatoprotective activity of ethanolic extract of Cassia fistula bark against CCL4 induced hepatic damage in Wistar rats. Pharmacologyonline. 2009; 2:50-63.
- Woods S, Seeley R, Rushing P, D’Alessio D, Tso P. A controlled high-fat diet induces an obese syndrome in rats. The J Nutr. 2003; 133(4):1081-7. https://doi.org/10.1093/jn/133.4.1081
- Jagadeeshwar K, Kulandaivelu U, GsnK Rao, Alavala RR, Panda SP. Evaluation of lipid lowering activity and anti-oxidant status of pithecellobium dulce in obesity induced rats. Indian J Pharm Sci. 2020; 82(6):1067-71. https://doi.org/10.36468/pharmaceutical-sciences.742
- Friedewald WT, Levey RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6):499-502. https://doi.org/10.1093/clinchem/18.6.499
- Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95(2):351-8. https://doi.org/10.1016/0003-2697(79)90738-3
- Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: Biochemical role as a component of glutathione peroxidase. Science. 1973; 179(4073):588-90. https://doi.org/10.1126/science.179.4073.588
- Bergmayer HU. Methods of enzymatic analysis. Verlag Chemie G.m.b.H., Weinheim/Bergstr. (Germany) and Academic Press, New York and London. Starch.1963; 15(7):237-74.
- McGown MW, Artuss JD, Strandbergh DR, Zak B. A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem. 1983; 29(3):538-43. https://doi.org/10.1093/clinchem/29.3.538
- Charles AW, John FK. Methods of enzymatic analysis, Metabolites 1: Carbohydrates. Br Polym J. 1985; 17(4):379. https://doi.org/10.1016/0308-8146(85)90039-1
- Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys. 1984; 21(2):130-2.
- Sinha AK. Colorimetric assay of catalase. Anal Biochem. 1972; 47(2):389-94. https://doi.org/10.1016/0003-2697(72)90132-7
- Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin- induced diabetic rats. Phytomedicine. 2006; 13(9-10):624-9. https://doi.org/10.1016/j.phymed. 2005.09.010
- Bais S, Singh GS, Sharma R. Antiobesity and hypolipidemic activity of Moringa oleifera leaves against high fat diet-induced obesity in rats. Adv Biol. 2014; 1-9. https://doi.org/10.1155/2014/162914
- Abbott RD, Wilson PW, Kannel WB, Castelli WP. High density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham Study. Arteriosclerosis. 1988; 8(3):207- 11. https://doi.org/10.1161/01.ATV.8.3.207
- Aune D, Sbhijit S, Sabrina S, Teresa N, Imre J, Romundastad P, et al. Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose-response meta-analysis of prospective studies. Eur J Epidemiol. 2017; 32(3):181- 92. https://doi.org/10.1007/s10654-017-0232-4
- Hariri N, Thibault L. High-fat diet-induced obesity in animal models. Nutr Res Rev. 2010; 23(2):270-99. https://doi.org/10.1017/S0954422410000168
- Sjostrom L. Review of the key results from the Swedish Obese Subjects (SOS) trial - A prospective controlled intervention study of bariatric surgery. J Intern Med. 2013; 273(3):219-34. https://doi.org/10.1111/joim.12012
- Kersten S. Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Reports. 2001; 2(4):282-6. https://doi.org/10.1093/embo-reports/ kve071
- Bederman IR, Steven F, Visvanathan C, James CA, Stephen FP. Triglyceride synthesis in epididymal adipose tissue. J Biol Chem. 2009; 284(10):6101-08. https://doi.org/10.1074/jbc.M808668200
- Parish S, Alison O, Robert C, Jemma CH, Michael RH, James DO, et al. Lipids and lipoproteins and risk of different vascular events in the mrc/bhf heart protection study. Circulation. 2012; 125(20):2469-78. https://doi.org/10.1161/CIRCULATIONAHA.111.073684
- Nakamura A, Terauchi Y. Lessons from mouse models of high-fat diet-induced NAFLD. Int J Mol Sci. 2013; 14; 21240-57. https://doi.org/10.3390/ijms141121240
- Mahluji S, Vahide EA, Majid M, Payahoo L, Alireza O, Samad EJG. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in Type-2 diabetic patients. Int J Food Sci Nutr. 2013; 64(6):682-6. https://doi.org/10.3109/09637486. 2013.775223
- David BA. Transaminases. FEBS Letters. 1985; 190:179-80. https://doi.org/10.1016/0014-5793(85) 80462-2