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G. Valli ¹, P. Karuppasamy ¹

Affiliations
1 The Standard Fireworks Rajaratnam College for Women, Sivakasi

Abstract

"A complex educational strategy designed to increase organisational effectiveness and wealth through planned intervention" - Dale S. Beech

Changes occur not only in technology but also in human values, attitudes, relationships, social system, organizational climate, culture etc. The organization has to meet the challenges of these changes by enhancing the professional skills, which in turn will lead to the organizational development. In an educational organization, in order to subsist in the competitive world, one such important factor involved is modernization of library by enhancing the library professional skills by adopting suitable strategic planning, which involve the Action Research Program. Library plays a vital role in the development of college status by providing a platform to do more research work and also the Human resource development. Hence modernization of library is an essential factor in an organizational development.

This paper deals with the various skills involved in enhancing the library professionals like technical, planning, organizational, conceptual, analytical, human and administrative skills, etc. and how the modernization of library plays a vital role in uplifting the status of the college while assessment for accreditation by National Accreditation and Assessment Council.

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G. Valli ¹, K. Ramu ², P. Mareeswari ²

Affiliations
1 Department of Chemistry, SFR College for Women, Sivakasi, Viruthunagar District, Tamil Nadu-626123, IN
2 Department of Chemistry, SFR College for Women, Sivakasi, IN

Abstract

The Schiff base 1,3-bis(2-hydroxybenzylidene)thiourea was prepared from salicylaldehyde and thiourea by condensation method using standard procedure. Analgesic and antipyretic activities 1,3-bis(2- hydroxybenzylidene)thiourea Schiff base were studied using albino rats of both the sexes. Animals were divided into three groups, each consisting of four animals. Group 1 served as control and group 2 received standard drug. Group 3 received 250 mg/kg of 1,3-bis(2-hydroxybenzylidene)thiourea . For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension. The analgesic activity was determined by tail immersion method. The results obtained showed that the Schiff base was found to exhibit analgesic, antipyretic activities. The analgesic activity of the Schiff base compared to the standard drug pentazocine was found to be higher in the first hour and then the activity decreases slowly. The reduction in the rectal temperature for this compound was observed to be less than the standard drug paracetamol. PASS prediction of 1,3-bis(2- hydroxybenzylidene)thiourea schiff base was found to exhibit Laccase inhibitor and Monophenol monooxygenase inhibitor activities greater than 90% and can also possessed other activities like Corticosteroid sidechain- isomerase inhibitor, 3-Hydroxybenzoate 4-monooxygenase inhibitor greater than 80%.

Keywords

Salicylaldehyde, Thiourea, Analgesic, Antipyretic and PASS.

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G. Valli ¹, R. Vijayalakshmi ², A. Vasanthi ², A. Thanga Thirupathi ³

Affiliations
1 Department of Chemistry, SFR College for women, Sivakasi, Tamil Nadu, IN
2 Department of Chemistry, SFR College for women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN

Abstract

Antipyretic and anti-inflammatory activities of different extracts of Odina woodier leaves were studied by observing decrease in rectal temperature and reduction in paw edema using albino rats of both sexes. Animals were divided into ten groups, each consisting of six animals. Group 1 served as control and Group 2 received the standard drug. Group 3-10 received various extracts of Odina woodier leaves. Group 3 received ethanol extracts of 200mg/kg and Group 4 received 400mg/kg. Group 5 and Group 6 received ethyl acetate extracts of 200mg/kg and 400mg/kg respectively. Similarly Group 7 and Group 8 received chloroform extracts of 200mg/kg and 400mg/kg. Group 9 received 200mg/kg and Group 10 received 400mg/kg petroleum ether extracts of Odina woodier leaves. For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension and for anti-inflammatory activity, inflammation was induced using 1% carageenan suspension. The results showed that all the extracts were found to have both antipyretic and anti-inflammatory activities. Among these four extracts, ethanol extract of 400 mg/kg have shown same antipyretic activity after four hours of drug administration as that of the standard Paracetamol drug which caused the reduction of temperature of 1.03 and 1.02 for the extracts and Paracetamol drug . 400mg/kg of ethyl acetate extract after two hours have shown higher anti-inflammatory activity (40.43%) with a probability < 0.001 than the chosen standard drug diclofenac sodium(39.75%) available as an anti-inflammatory drug in the market.

Keywords

Antipyretic, Anti-Inflammatory, Carageenan, Pyrexia and Odina Woodier.

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G. Valli ¹, P. Mareeswari ², K. Ramu ², A. Thanga Thirupathi ³

Affiliations
1 S.F.R. College for Women, Sivakasi, Viruthunagar District, Tamil Nadu, IN
2 Department of Chemistry, S.F.R College for Women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN

Abstract

The Schiff base 4-(4-hydroxy benzylidene amino)phenol was prepared from p-hydroxybenzaldehyde and 4-aminophenol by condensation method using standard procedure. Analgesic, antipyretic and CNS activities of 4-(4- hydroxy benzylidene amino) phenol Schiff base were studied using albino rats of both the sexes. Animals were divided into three groups, each consisting of four animals. Group 1 served as control and group 2 received standard drug. Group 3 received 250 mg/kg of 4-(4-hydroxy benzylidene amino) phenol. For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension. The analgesic activity was determined by tail immersion method. CNS depressant activity of the compound was measured by placing the rat individually in the actophotometer for 10 min. The results obtained showed that the Schiff base was found to exhibit analgesic, antipyretic and CNS activities. The analgesic activity of the Schiff base compared to the standard drug pentazocine was found to be higher in the first hour and then the activity decreases slowly. The reduction in the rectal temperature for this compound was observed to be less than the standard drug paracetamol. 4-(4-hydroxy benzylidene amino)phenol Schiff base of 250mg/kg possessed CNS stimulant activity with a probability <0.001. 4-(4-hydroxy benzylidene amino)phenol Schiff base was found to possess highest glutathione thiolesterase inhibitor activity as 86% and other activities greater than 80% as per the prediction using PASS (online bioactivity prediction software) .

Keywords

P-Hydroxybenzaldehyde, 4-Aminophenol, Analgesic, Antipyretic , CNS and PASS.

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G. Valli ¹, M. Jeyalakshmi ¹

Affiliations
1 Department of Chemistry, S.F.R College for Women, Sivakasi-626123, Tamil Nadu, IN

Abstract

Our present study deals with the finding of the phytochemical constituents present in Odina woodier leaf extracts. It was performed by generally accepted laboratory technique for qualitative determination. It was observed that alkaloids, flavanoids, tannins, steroids were present more in ethanol and methanol extract and were present in lesser amount in ethyl acetate extract. Other constituents like carbohydrate, phenolic compounds, proteins etc., were found to be absent in all the extracts. In-vitro anti oxidant study of DPPH radical scavenging at different concentration (25- 200 μg/ml) in methanol and ethyl acetate extract of Odina woodier leaf were measured. The radical scavenging effect was found to increase with increasing concentrations. The methanol extract showed the maximum activity of 96% at a concentration of 200μg/ml. The ethyl acetate extract showed the activity of 46% at a concentration of 200μg/ml.

Keywords

Odina woodier, DPPH, Antioxidant.

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