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M, Gokul Raj
- In vitro Study of Antioxidant, Antidiabetic and Antimicrobial Activities of Solanum Torvum Root
Authors
1 (Department of Biotechnology, Adhiyamaan College of Engineering, Hosur (Autonomous), Anna Univertsity, Chennai - 600 025, Tamil Nadu., IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 60, No 1 (2023), Pagination: 143-155Abstract
Diabetes mellitus is a metabolic disorder with characteristics of multiple aetiology of chronic hyperglycaemia. These effects include dysfunction and long-term degeneration of various organs. Characteristics of diabetes mellitus include polyuria, blurred vision, thirst, and weight loss. Many types of insulin are available, for example porcine insulin, beef insulin, and human insulin. Weight gain and hypoglycaemia are the most adverse effects of using insulin. Insulin binds to sulfonylurea receptors on β-cell plasma membranes. In this study, ethanolic extract of Solanum torvum root was used to study ATP-sensitive potassium channels, which lead to depolarized cell membranes. The ethanolic extract was also analysed for antioxidant activities by free radical 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging method. The different concentration of extracts exhibited varying result of radical scavenging activity using DPPH as substrate. The root of Solanum torvum exhibited significant α-amylase (79.56%) and α-glucosidase (80.58%) inhibitory activities at the concentration 100 μg/ml respectively when compared with standard acarbose drug. It also showed a good antioxidant activity with 65.47% when compared with standard ascorbic acid. The ethanolic extract of Solanum torvum root has a potential antimicrobial activity against Staphylococcus aureus and Candida tropicalis. Thus, Solanum torvum is a better source for natural antioxidant, anti-diabetic and anti-microbial activities due to presence of natural compounds in it.
Keywords
Antioxidant, Anti-Diabetic, Anti-Microbial, DPPH Assay, α-Amylase Assay, α-Glucosidase AssayReferences
- Yeh, G.Y., Eisenberg, D.M., Kaptchuk, T.J. and Phillips, R.S. Systematic review of herbs and dietary supplements for glycemic control in diabetes, Diabetes Care, 2003, 26, 1277-1294.
- Alarcon, A.F.J., Roman, R.R., Flores, S.J.L. and Aguirre, G.F. Investigation on the hypoglycaemic effects of extracts of four mexican medicinal plants in normal and alloxan-diabetic mice, Phytother. Res., 2022, 16, 383-386.
- Koech, K., Wachira, F.N., Ngure, R., Wanyoko, J., Bii, C. and Karori, S. Antimicrobial, synergistic and antioxidant activities of tea polyphenols. Afr. Crop Sci. J., 2014, 22, 837-846.
- Zimmet, P., Alberti, K.G. and Shaw, J. Global and societal implications of the diabetes epidemic. Nature, 2001, 414, 782-787.
- Danaei, G., Finucane, M.M., Lu, Y., Singh, G.M., Cowan, M.J. and Paciorek, C.J. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980; Systematic analysis of health examination surveys and epidemiological studies with 370 country years and 2.7 million participants. Lancet, 2011, 378, 31-40.
- Kearns, K., Dee, A., Fitzgerald, A., Doherty, E. and Perry, I.J. Chronic disease burden associated with overweight and obesity in Ireland; The effects of a small BMI reduction at population level. BMC. Pub. Healt., 2014, 14, 143.
- Ahmed, F., Kahalid, P., Khan, M.M., Rastogi, A.K. and Kidwai, J.R. Insulin like activity in (-)-epicatechin, Acta. Diaetol. Lat., 1989, 26, 291-300.
- Biney, E.E., Nkoom, M., Darkwah, W.K. and Puplampu, J.B. High-performance liquid chromatography analysis and antioxidant activities of extract of Azadirachta indica (neem) leaves. Pharmacogn. Res., 2019, 12, 29-34.
- Chopra. R.N., Nayar S.L. and Chopra. I.C., Glossary of Indian medicinal plants (New Delhi: National Institute of Science Communication, 1996.
- Deepti rathee, Permender Rathee, Akash Deep, Shetal Anandjiwala and Dharmender Rathee. HPTLC densitometric quantification of stigmasterol and Lupeol from Ficus religosa. Arab. J. Chem., 2015, 8, 366 -371.
- Braca, A., Sortino, C. and Politi, M. Antioxidant activity of flavonoids from Licaniali caniaeflora. J. Ethnopharmacol., 2002, 79, 379-381.
- McCue, P.P. and Shetty, K. Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylase in vitro. Asia pacific J. Clin. Nutr., 2004, 13, 101-106.
- Muneer, A.J., Sirajudeen, J. and Abdul vahith, R. In vitro anti-diabetic activity of Solanum erianthum. Int. J. Res. Analy. Rev., 2019, 6, 41-44.
- Kim, S.K., Jung, S.M., Ahn, K.H., Jeon, H.J., Lee, D.H., Jung, K.M., Jung, S.Y. and Kim, D.K. Identification of three competitive inhibitors for membrane-associated, Mg2+dependent and neutral 60 kDa sphingomyelinase activity. Arch. Pharm. Res., 2005, 28, 923-929.
- Cédric Sima Obiang, Rick Léonid Ngoua Meye Misso, Guy Roger Ndong Atome, Joseph Privat Ondo, Louis Clément Obame Engonga and Edouard Nsi Emvo. Phytochemical analyses, antimicrobial and antioxidant activities of stem bark extracts of Distemonanthus benthamianus H. Baill. and fruit extracts of Solanum torvum Swartz from Gabon. Asian Pacific J. Trop. Biomed., 2019, 9, 209-216.
- Waghulde, H., Kamble, S., Patankar, P., Jaiswal, B.S., Pattanayak, S., Bhagat, C. and Mohan, M. Antioxidant activity, phenol and flavonoid contents of seeds of Punica granatum (Punicaceae) and Solanum Torvum (Solanaceae). Pharmacol. online, 2011, 1, 193-202.
- Gandhi, G.R.P. and Sasikumar, P. Antidiabetic effect of Merremia emarginata Burm. F. in Streptozotocin induced diabetic rats. Asian Pacific J. Trop. Biomed., 2012, 2, 281- 286.
- Malvi, R., Jain, S., Khatri, S., Patel, A. and Mishra, S. A review on anti-diabetic medicinal plants and marketed herbal formulations. Int. J. Pharmaceu. Biolog. Arch., 2011, 2, 1347.
- Singhal, A.K., Naithani, V. and Bangar, O.P. Medicinal plants with a potential to treat Alzheimer and associated symptoms. Int. J. Nutr. Pharmacol. Neurolog. Dis., 2012, 2, 84-91.
- Abhishek, R.U., Thippeswamy, S., Manjunath, K. and Mohana, D.C. Antifungal and antimycotoxigenic potency of Solanum torvum Swartz. leaf extract: Isolation and identification of compound active against mycotoxigenic strains of Aspergillus flavus and Fusarium verticillioides. J. Appl. Microbiol., 2015, 119, 1624-1636.
- Chah, K.F., Muko, K.N. and Oboegbulem, S.I. Antimicrobial activity of methanolic extract of Solanum torvum fruit. Fitoterapia, 2000, 71, 187-189.