Abstract
As the environment becomes polluted more and more the number of pathogens causing diseases are also enormously increasing. With the increasing analytical techinques, more number of newer pathogens are discovered. As this number is going on increasing, the need for potential antibiotics is also increasing day by day. Having this point in mind, we have planned to synthesize some Schiff base transition metal complexes, to assess their antibacterial activity. So, we have prepared the transition metal complexes of the metal ions Fe(II), Cu(II), Hg(II),Co(II) and Zn(II) using the Schiff base derived from salicylaldehyde and p- methoxy aniline. The Schiff base was first prepared by condensing salicylaldehyde and p- methoxy aniline.Using this as the ligand, the Schiff base metal complexes were prepared with Fe(II), Cu(II), Hg(II), Co(II) and Zn(II) as metal ions. The structure of the ligand was confirmed by IR, UV-Visible and 1H- NMR spectra. The shift in the spectral bands of the ligands up on complexation was also confirmed by taking the spectra of complexes.Using this we have proposed the possible common structure for the complex. To access the antibacterial ability of these metal complexes, anti bacterial activity of Schiff base transition metal complexes against the bacterias Pseudomonas sp, Klebsiella sp, Bacillus sp, Staphylococcus sp, E.col, Micrococcus, Proteus sp, Pseudomonas fluorescence and Salomonella enterica are estimated by finding out their zone of inhibition using disc diffusion method. We have observed that higher antimicrobial activity of 8mm in mercury complex against bacillus sp.
