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Authors
Affiliations
1 Gyan Vihar School of Pharmacy, SGVU, Mahal Road, Jagatpura, Jaipur, IN
2 Lordshiva College of Pharmacy, Sirsa, Haryana, IN
3 Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 5 (2012), Pagination: 272-277
Abstract
Aim:- The present study is to formulate the matrix type transdermal patches of Nebivolol hydrochloride as a model drug with combination of HPMC K100M and ERS-100 to minimize the dose of the drug for lesser side effect.
Method:-Matrix type transdermal patches containing Nebivolol hydrochloride were prepared using two polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide was used as penetration enhancer. Major
Results:-The physicochemical parameters like weight variation, thickness, folding endurance, drug content, Percentage moisture absorption and Percentage moisture loss were evaluated. All prepared formulations indicated good physical stability and no skin irritation. In-vitro drug release and drug permeation studies of formulations were performed by using Franz diffusion cells. Formulation prepared with hydrophilic polymer containing permeation enhancer showed best in-vitro skin permeation through rat skin (Wistar albino rat) as compared to all other formulations.
Conclusions:- On the basis of in vitro drug release through skin permeation performance, Formulation F1 was found to be better than other formulations and it was selected as the optimized formulation.
Keywords
Nebivolol Hydrochloride, Transdermal Patch, Polymers, Solvent Evaporation Technique, Skin Permeation.
