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Sambasivarao, K. R. S.
- Formulation and In-Vitro Evaluation of Indomethacin Microcapsules
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Affiliations
1 Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh- 522101, IN
2 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, IN
3 Deportment of Biotechnology, Achrya Nagarjuna University, Gunter, Andhra Pradesh., IN
1 Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh- 522101, IN
2 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, IN
3 Deportment of Biotechnology, Achrya Nagarjuna University, Gunter, Andhra Pradesh., IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 1 (2012), Pagination: 44-47Abstract
The objective of this research was to formulate and evaluate the Indomethecin microcapsules for controlled drug delivery by emulsification solvent evaporation technique, employing Eutragit RL100 as coating material. Prepared microcapsules were evaluated for average particle size, Flow properties, Microencapsulation efficiency and invitro drug release studies. The drug-polymer interaction evaluated by FT-IR spectroscopy. They were found to be discrete, free flowing high percentage of drug entrapment efficiency and also retard the release for 12 hrs. The in vitro dissolution study confirmed that the formulations followed zero order kinetics and peppas release mechanism.Keywords
Indomethacin, Eudragit RL 100,MicroCapsues,FT-IR.- Phytase Production by Rhizopus oligosporus MTCC556 under Submerged Fermentation Conditions
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Authors
Affiliations
1 Centre for Biotechnology, Acharya Nagarjuna University, Guntur (A.P.), IN
1 Centre for Biotechnology, Acharya Nagarjuna University, Guntur (A.P.), IN