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Manimekalai, K.
- Evaluation of Hepatoprotective Activity of Ethanolic Extract of Aerial Parts of Premna tomentosa against Paracetamol-Induced Liver Toxicity on Wistar Rats
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Authors
Affiliations
1 Dept. of Pharmacology, Mahatma Gandhi Medical College & Research Institute, Puducherry, IN
1 Dept. of Pharmacology, Mahatma Gandhi Medical College & Research Institute, Puducherry, IN
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Toxicology International (Formerly Indian Journal of Toxicology), Vol 23, No 2 (2016), Pagination: 112-121Abstract
Hepatoprotective activity of ethanolic extract of aerial parts of Premna tomentosa were evaluated against paracetamol-induced liver toxicity and comparison to the standard hepatoprotectant, silymarin. Thirty male wistar albino rats were randomised into five groups with six rats in each group. Group A&B sereved as normal control and toxic control respectively, and were administered normal saline. Group C& D were treated with ethanolic extract of Premna tomentosa at doses 100mg/kg and 200mg/kg respectively. Group E was treated with the standard drug Silymarin 25mg/kg. Toxicity was induced in all the groups except the first by giving Paracetamol at 2g/kg on the 5th day. All the rats were treated for 7 days and after the last dosing the rats were fasted for 24hrs and sacrificed. Serum was sent for biochemical analysis for assaying liver profile. Histopathology and antioxidant studies were done on liver. In our study ethanolic extract Premna tomentosa showed beneficial effect on paracetamol induced liver toxicity which was evident by the significant improvement in liver profile consisting of AST, ALT, ALP, GGT, total cholesterol, total protein, triglycerides and total bilirubin in a dose dependent manner, which is consistent with the histopathological findings. Increase in GSH and Catalase and decrease in TBARS validates the antioxidant property of the extract. The study has proved that Premna tomentosa posses a significant hepatoprotective activity which was comparable to the standard drug silymarin. It warrants further study in humans before including it in the prevention of hepatotoxicity.Keywords
Premna tomentosa, Paracetamol, Hepatoprotective, Antioxidant.References
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- Missing Value Imputation and Normalization Techniques in Myocardial Infarction
Abstract Views :249 |
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Authors
K. Manimekalai
1,
A. Kavitha
2
Affiliations
1 Department of Computer Applications, Sri GVG Visalakshi College for Women, IN
2 Department of Computer Science, Kongunadu Arts and Science College, IN
1 Department of Computer Applications, Sri GVG Visalakshi College for Women, IN
2 Department of Computer Science, Kongunadu Arts and Science College, IN
Source
ICTACT Journal on Soft Computing, Vol 8, No 3 (2018), Pagination: 1655-1662Abstract
Missing Data imputation is an important research topic in data mining. In general, real data contains missing values. The presence of the missing value in the data set has a major problem for precise prediction. The objective of this paper is to highlight possible improvement of existing algorithm for medical data. KNBP imputation method based on KNN and BPCA is proposed and evaluate MSE and RMSE estimates. Normalization is done by comparing three algorithms namely min-max normalization, Z-score and decimal scaling. The experiment is done with standard bench mark data and real time collected data. KNBP imputation method and Decimal Scaling Algorithm for Normalization got lower error rate.Keywords
Mean, Hot Deck, KNN, BPCA, KNBP, Min-Max Algorithm, Z-Score, Decimal Scaling.References
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- Acute Oral Toxicity of Essential Oil Extracted from the Leaves of Ocimum Sanctum L. (Thulasi) in Female Wistar Albino Rats.
Abstract Views :305 |
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Authors
Venugopal Jayapal
1,
V. Subha
2,
K. Bhavani
3,
Kartik Janardan Salwe
4,
K. Manimekalai
5,
Josh M Easow
6,
Stephen Selvaraj
7
Affiliations
1 Professor of Microbiology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Deemed to be University, Puducherry., IN
2 Veterinary surgeon, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
3 Associate Professor, Pathology Department, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
4 Professor, Pharmacology Department, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
5 Professor and HOD, Pharmacology Department, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
6 Professor and HOD, Microbiology Department, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
7 Professor, Microbiology department, Mahatma Gandhi Medical College and Research Center., Puducherry., IN
1 Professor of Microbiology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Deemed to be University, Puducherry., IN
2 Veterinary surgeon, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
3 Associate Professor, Pathology Department, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
4 Professor, Pharmacology Department, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
5 Professor and HOD, Pharmacology Department, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
6 Professor and HOD, Microbiology Department, Mahatma Gandhi Medical College and Research Institute, Puducherry., IN
7 Professor, Microbiology department, Mahatma Gandhi Medical College and Research Center., Puducherry., IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1827-1830Abstract
Due to the widespread use of antimicrobial agents, many Microorganisms have developed drug resistance to many available antimicrobials today. Essential oils from different plants are being explored for their ability to treat various human diseases, including infectious diseases. Earlier, we have found that the essential oil from the leaves of Ocimum sanctum L. had anti bacterial effect on 18 human pathogenic bacteria. In the present study, the essential oil of Ocimum sanctum L. was evaluated for its toxic effects at 300 mg / Kg body weight and 2000 mg / Kg body weight of female Wistar albino rats as per the OECD Guidelines 423 for testing of chemicals. The 14 day acute oral toxicity test has shown Ocimum sanctum L. essential oil is not toxic at 300 mg / Kg body weight of animals but has some toxic effects at 2000 mg /Kg body weight of animals. However, no animals died during the 14 day acute oral toxicity test with 2000 mg / Kg body weight of animals and therefore the LD50 dose of Ocimum sanctum L. should be more than 2000 mg / Kg of body weight of female Wister albino rats.Keywords
Ocimum sanctum, Essential oil, Acute oral toxicity, Wistar albino female rats, Thulasi.References
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