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- Haematolohical Profile of Subacute Oral Toxicity of Molybdenum and Ameliorative Efficacy of Copper Salt in Goats
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Authors
Affiliations
1 Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir, IN
2 Veterinary Physiology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir, IN
1 Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir, IN
2 Veterinary Physiology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 2 (2010), Pagination: 82-85Abstract
Molybdenum toxicity produces a state of secondary hypocuprosis, resulting into alterations in normal hematological profile. In the present study, ammonium molybdate alone and with copper sulfate (II) pentahydrate (ameliorative agent) was administered orally for 30 consecutive days in healthy goats of group 1 and 2, respectively, to access the effect on the hematological profile on different predetermined days of dosing. Administration of ammonium molybdate alone produced significant decline in the mean values of hemoglobin (Hb), packed cell volume (PCV), total leukocyte count (TLC), total erythrocyte count (TEC), and mean corpuscular hemoglobin concentration (MCHC), with a significant increase in neutrophil level and mean corpuscular volume (MCV). However, values of erythrocyte sedimentation rate, mean corpuscular hemoglobin, and differential leukocyte count were not significantly altered. On comparing observations of ameliorative group with the group 1 goats, it is concluded that the ameliorative copper salt has beneficial effects in alleviating the alterations in the values of Hb, PCV, TLC, TEC, MCV, MCHC, and neutrophils.Keywords
Ammonium molybdate, copper sulfate, goats, hematological profile- Effect of repeated dermal application of α-cypermethrin on lipid peroxidation and antioxidant system in rats
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Authors
Affiliations
1 Division of Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology – Jammu. R. S. Pura, Jammu- 181102, IN
2 Division of Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology – Jammu. R. S. Pura, Jammu- 181102
1 Division of Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology – Jammu. R. S. Pura, Jammu- 181102, IN
2 Division of Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology – Jammu. R. S. Pura, Jammu- 181102
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 16, No 1 (2009), Pagination: 27-30Abstract
α-Cypermethrin, a pyrethroid insecticide has a wide use for crop protection and ectoparasitic control in domestic animals. Excessive dermal exposure due to environmental contamination or inadvertent use may result in hazardous effects in man and animals. In present study the various biomarkers for the oxidative stress have been studied in Wister rats. SOD and catalase activities in erythrocytes were significantly decreased after 30 day of dermal exposure although these were initially over expressed. There was significant decrease (p<0.05) in blood GSH level and GPx activities in all the three groups. Enzymatic activity of GST was not significantly affected on any day of the exposure. Significant increase in lipid peroxidation of erythrocyte membrane from 10 days onwards exposure was also observed. The evaluated enzymatic and non-enzymatic components of the cell suggest that dermal exposure of ?-cypermethrin produces oxidative stress in rats.Keywords
α-cypermethrin, antioxidant system, dermal application, lipid peroxidation- Haematological profile of subacute oral toxicity of fluoride and ameliorative efficacy of aluminium sulphate in goats
Abstract Views :148 |
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Authors
Affiliations
1 Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K, IN
2 Division of Veterinary Physiology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K
3 Director, National Dairy Research Institute, Karnal, Haryana, IN
1 Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K, IN
2 Division of Veterinary Physiology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K
3 Director, National Dairy Research Institute, Karnal, Haryana, IN