A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kalaivani, M.
- Knowledge on Preschool Behavioural Problems among Mothers Residing at Kollapatti Village, Namakkal District
Authors
1 Dhanvantri College of Nursing, Ganapathypuram, No – 1 Ranganoor Road, Muniyappan Kovil, Pallakkapalyam, Namakkal District – 637 303, IN
Source
International Journal of Nursing Education and Research, Vol 2, No 3 (2014), Pagination: 221-223Abstract
Background: The behaviour develops from intrauterine period itself. Each stage of development the child is learning from the parents, peer groups and the environment. These are the factors which influence the behaviour of the children.
Objectives: To assess the knowledge of preschool behavioural problems among mothers. Design: A cross - sectional descriptive design was adopted for the study.
Setting: Kollapatti Village, Namakkal District.
Participants: 30 mothers fulfilling the inclusion criteria were selected by purposive sampling technique.
Methods: All participants were given a questionnaire to complete; questions were related to Baseline Proforma of mothers and standard questionnaire on behavioural problems administered 20 - 25 minutes to complete the questionnaire.
Results: The findings revealed that Knowledge of mothers shows that 80% of the mothers having inadequate knowledge and 20% of them having moderately adequate knowledge on behavioral problems. There is no significant association between selected demographic variables and level of knowledge on preschool behavioural problems among mothers (P > 0.005).
Conclusion: Mothers are having was very poor knowledge regarding behavioural problems. There is a need to educate parents on behaviour of children and the significance of behavioural deviations.
Keywords
Behavioural Problems, Mothers, Preschool Children.
- Development and Validation of an Analytical Liquid Chromatography-Tandem Mass Spectroscopy Method for the Estimation Febuxostat in Pharmaceutical Formulation
Authors
1 Department of Pharmaceutical Analysis, JSS College of Pharmacy (JSS Academy of Higher Education and Research, Mysuru) Udhagamandalam, IN
2 Indian Pharmacopoeia Commission, New Delhi, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2137-2140Abstract
A rapid LC-MS/MS method has been developed and validated for the quantitative determination of Febuxostat from the commercially available formulations. The separation was achieved using Zorbax SB C18 column (4.6 × 50 mm, 5 μm) as a stationary phase and the mobile phase consists of (10 mM) Ammonium formate (pH4.0): methanol (10:90 v/v) with a flow of 0.6 mL/min. Detection was carried out by triple quadrupole mass spectrometry with electrospray ionization in positive mode with proton adducts at m/z 316.95→260.95 to monitor Febuxostat within a run time of 2 min. The linearity of the method was found over a concentration range of 4 to 55 ng/mL with a regression analysis of 0.997. The percentage recovery of the present method was found to be 97.16 to 99.46%. The LC-MS/MS method was validated as per ICH guidelines. The developed method can be successfully applied for the estimation of Febuxostat in the commercial formulation and in bulk drug.Keywords
Febuxostat, Formulation, LC-MS/MS, Validation, Electrospray Ionization.References
- Drug details, URL: https://pubchem.ncbi.nlm.nih.gov/compound/Febuxostat#section=Top
- Rajyalakshmi Ch., Benjamin T., Ram Babu C. Development and Validation of Zero and First Order Derivative UV-Spectrophotometric Method for Determination of Febuxostat in Bulk and in Formulation. Research. J. Pharm. and Tech. 2013; 6(2): 208-211.
- J. M. Derasari, V. B. Patel. Spectrophotometric Determination of Febuxostat and Diclofenac Potassium in Their Combined Dosage Form by Simultaneous Equation and First Order Derivative Methods. Asian J. Research Chem. 2013; 6(10): Page 968-972.
- D. M. Darandale, K.B. Erande, S.R. Tambe, R.S. Bhamber. Development and Validation of RP-HPLC Method for the Determination of Febuxostat in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 2017; 10(6):713-718.
- Muvvala SS, Ratnakaram VN, Nadendla RR. Validated RP-HPLC method for the estimation of febuxostat in bulk drugs. Int J pharmTech Res. 2012; 4(4): 1358-1366.
- Kumar RS, Ravikumar BVV, Anjaya Kumar P. A RP-HPLC method development and validation for estimation of febuxostat bulk and pharmaceutical dosage forms. Int Res J Pharm. 2012; 3(11): 205-208.
- Chandu BR, Kanala K, Hwisa NT, Katakam P, Khagga M. Bio-equivalance and pharmacokinetic study of febuxostat in human plasma by using LC-MS/MS with liquid liquid extraction method. Spinger plus, 2013; 2(194): 1-10.
- Pal N, Rao AS, Kumar PR. New method development and validation for the determination of febuxostat in human plasma by liquid chromatography –mass spectrometry. Int J Pharm Pharm Sci. 2016; 8(9): 61-70.
- Mitesh D Phale, Dipti Korgaonkar. Current Advance Analytical Techniques: A Review. Asian J. Research Chem. 2009; 2(3): 235-238.
- ICH validation, URL:https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf.