Informatics Publishing Limited

P. Jaya Preethi ¹, M. Lohita ¹, P. Swarna Latha ¹, S. Zameerullah ¹, K. Veeranjineyulu ¹, A. Manohara ¹

Affiliations
1 Department of Pharmacy, Sree Vidyanikethan College of Pharmacy, Sri Sainath Nagar, Tirupati-517102, IN

Abstract

Despite many achievements in human health care in the twenty first century, population in developing countries lack regular access to affordable essential drugs. For these people, modern medicine is never likely to be a realistic treatment option. In contrast medicinal plants are widely available and affordable, even in remote areas. The cost of modern medicine is increasing by modern health technology and in many cases is inappropriate to the immediate needs of people in developing countries. This review concentrates on those recent advances in science and technology that offer possible inroads for shifting the paradigm for herb-based contraception.

Keywords

Antifertility, Contraceptive, Abortification, Fabaceae, Herbs.

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G. Shobha Rani ¹, M. Lohita ¹, P. Jaya Preethi ¹, R. Madhavi ¹, B. Sunisitha ¹, D. Mounika ¹

Affiliations
1 Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102, Andhra Pradesh, IN

Abstract

Glimepiride is an oral anti-diabetic drug, which is mostly used in the treatment of Type 2 diabetes mellitus. It acts by stimulating insulin secretions from the beta cells of pancreas and is also known to enhance the peripheral insulin sensitivity thereby decreasing insulin resistance. This article examines published analytical methods that are reported so far for the determination of glimepiride in pharmaceutical formulations and biological samples. They include various techniques like spectrophotometry, electrochemical methods, capillary electrophoresis, high-performance liquid chromatography, micellarelectro kinetic capillary chromatography(MECC) with diode-array detection (DAD), liquid chromatography-electrospray ionization-tandem mass spectroscopy (LC-ESI-MS), liquid chromatography-mass spectroscopy (LC-MS) and thin layer chromatography (TLC).

Keywords

Glimepiride, Analytical Methods, Type 2 Diabetes Mellitus.

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P. Jaya Preethi ¹, E. Karthikeyan ¹, M. Lohita ¹, P. Goutham Teja ¹, M. Subhash ¹, P. Shaheena ¹, Y. Prashanth ¹, K. Sai Nandhu ¹

Affiliations
1 Department of Pharmacy, Sree Vidyanikethan College of Pharmacy, Tirupati, IN

Abstract

Benzimidazole is the heterocyclic compound formed by the fusion of benzene and imidazole ring. Benzimidazole derivatives belong to a crucial structural design that is seen in many pharmaceutically and biologically interesting molecules. Benzimidazole has shown potential for application in a variety of pharmacological targets. They have been intensively used in medicinal chemistry as drugs such as antihistaminic, antiulcerative, antihelmentic, antipsychotic etc. Benzimidazole is outstandingly effective compounds and there are a number of reviews available for biochemical and pharmacological studies which confirmed that these molecules are useful against a wide variety of microorganisms. For these reasons, they achieved much attention as important pharmacophore and privileged structure in medicinal chemistry. This review summarizes to know about the different derivatives of Benzimidazole.

Keywords

Pharmacological Activities, Substituted Benzimidazole, Benzimidazole Derivatives.

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P. Jaya Preethi ¹, W. Shinto Authur ¹, M. Lohita ¹, K. Swetha ¹, D. Naresh ¹

Affiliations
1 Department of Pharmacy, Sree Vidyanikethan College of Pharmacy, Sri Sainath nagar, Tirupati-517102, IN

Abstract

Plants have been the beacon of therapeutic sources for curing diseases from times immemorial. We emphasize the role of information derived from various systems of traditional medicine (ethnomedicine) and its utility for drug discovery purposes. Cancer is a dreadful disease characterized by the irregular proliferation of the cells. As a cell progresses from normal to cancerous, the biological imperative to survive and perpetuate drives fundamental changes in cell behaviour. An attempt has been made to review some medicinal plants used for the prevention and treatment of cancer.

Keywords

Anticancer, Medicinal Plants, Herbal Medicine, Cancer Treatment, Curcuma Longa, Azadirachata Indica.

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P. Jaya Preethi ¹, M. Lohita ¹, Swarna Latha ¹, S. Zameerullah ¹, K. Veeranjineyulu ¹, A. Manohara ¹

Affiliations
1 Department of Pharmacy, Sree Vidyanikethan College of Pharmacy, Sri Sainath Nagar, Tirupati-517102, IN

Abstract

Despite many achievements in human health care in the twenty first century, population in developing countries lack regular access to affordable essential drugs. For these people, modern medicine is never likely to be a realistic treatment option. In contrast medicinal plants are widely available and affordable, even in remote areas. The cost of modern medicine is increasing by modern health technology and in many cases is inappropriate to the immediate needs of people in developing countries. This review concentrates on those recent advances in science and technology that offer possible inroads for shifting the paradigm for herb-based contraception.

Keywords

Antifertility, Contraceptive, Abortification, Fabaceae, Herbs.

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S. Eswaraiah ¹, K. Swetha ¹, M. Lohita ², P. Jaya Preethi ³, B. Priyanka ⁴, Kiran Kumar Reddy ⁴

Affiliations
1 Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, IN
3 Department of Pharmaceutical Chemistry, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, IN
4 Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, IN

Abstract

A gel is colloid that is typically 99% by weight liquid. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state. A major limitation is in the delivery of hydrophobic drugs. To overcome the limitation a novel approach i.e. an emulsion based approach is being used so that even a hydrophobic moiety can enjoy the unique properties of gels. When gel and emulsion are used in combined form the dosage form are referred as emulgel. Emulgels have emerged as one of the most interesting topical delivery system as it has dual release control system i.e. gel and emulsion. The presence of a gelling agent in the water phase converts a classical emulsion into an emulgel. Emulgels for dermatological use have several favorable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non staining, water-soluble, longer shelf life, bio-friendly, transparent and pleasing appearance. The use of emulgel can be extended in analgesics and antifungal drugs.

Keywords

Emulgel, Hydrophobic, Topical Drug Delivery.

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P. Jaya Preethi ¹, K. Padmini ¹, J. Srikanth ¹, M. Lohita ¹, K. Swetha ¹

Affiliations
1 Department of Pharmacy, Sri Vidyanikethan College of Pharmacy, Sri Sainath Nagar, Tirupati-517102, IN

Abstract

Central nervous system (CNS) stimulants are medicines that speed up physical and mental processes. Central nervous system stimulants are used to treat conditions characterized by lack of adrenergic stimulation, including narcolepsy and neonatal apnea. Additionally, methylphenidate (Ritalin) and dextroamphetamine sulfate (Dexedrine) are used for their paradoxical effect in attention-deficit hyperactivity disorder (ADHD). The majority of CNS stimulants is chemically similar to the neurohormone norepinephrine and simulates the traditional "fight or flight" syndrome associated with sympathetic nervous system arousal. Caffeine is more closely related to the xanthines, such as theophylline. A small number of additional members of the CNS stimulant class do not fall into specific chemical groups. The review on central nervous system stimulants gives detail study of CNS stimulant drugs, their mechanism of action and in vivo models of CNS stimulants.

Keywords

CNS Stimulant, Actophotometer, Rota Rod, Open Field Test, Elevated Plus Maze.

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