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Nadeem Siddiqui ¹, Md Shamsher Alam ¹, Meeta Sahu ¹, M. Shahar Yar ¹, Ozair Alam ¹, Mohammad Jamshed Ahmad Siddiqui ²

Affiliations
1 Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi-110062, IN
2 Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University, Malaysia, Kuantan 25200, MY

Abstract

Purpose. Benzimidazole class of compound is found to have diverse biological properties. From the literature study, it is observed that depression is a severe mental disease affecting a huge population and pain is affecting about 20% of world population. In continuation of our previous research work, we selected benzimidazole pharmacophore to further explore its pharmacological activities. Methods. Forced swim test and Thermal stimulus test were used to assess the antidepressant and analgesic activity of synthesized benzimidazole analogs. Results. The antidepressant activity results showed that compound 3j was found most potent having Mean ± SEM value 21.6 ± 0.8 for treated group. Furthermore, in the analgesic test, 3b, 3j, and 3o showed Mean ± SEM values; 1.8 ± 0.10, 2.3 ± 0.10 and 2.2 ± 0.10, respectively. The study results suggested that these compounds could be explored further for the development of better antidepressant and analgesic agents. Conclusion. From the present study, it may be concluded that these active benzimidazole derivatives have been found to possess potential antidepressant and analgesic activity.

Keywords

Benzimidazole, Antidepressant, Analgesic, Structure Activity Relationship, Log P.

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Rakesh Saini ¹, Saurabh Chaturvedi ¹, M. Shahar Yar ², H. P. Bhartiya ³, Pratibha Singh ³

Affiliations
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN
3 Govt. P.G. College, Hamirpur (U.P), IN

Abstract

Polygonatum verticillatum, Convallariaceae erect glabrous herb upto 20 cm. in height with thick ischolar_main stock. Upper part of the stem the leafy zig-zag grooved, leaves whorled sensible linear or lanceolate flowers 2-3 together, white, pinkish and white or pale green in whorled racemes fruits berries, red when ripe. Root stock is sweet, cooling, Emollient, Diuretic aphrodisiac, galactogogue, appetizing, tonic. It is useful in vitiated condition of pitas and vat, burning sensation fever, stongury, seminal weakness, anorexia and general debility. The author have done some work and isolated few higher fatty acids from the rhizome of this plant.

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Saurabh Chaturvedi ¹, Rakesh Saini ¹, A. N. Kesari ¹, Awani Rai ¹, Neelotma Maurya ¹, M. Shahar Yar ²

Affiliations
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN

Abstract

A new series of NSAID’S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.

Keywords

NSAID’S, Aspirin, Anti-Platelet Agents, Pyrrole.

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Rakesh Saini ¹, Awani K. Rai ¹, A. N. Kesari ¹, M. Shahar Yar ²

Affiliations
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, IN
2 Department of Pharmacy, Jamia Hamdurd, New Delhi, IN

Abstract

Synthesis of (ethyl 2-(1H Benzo [d] [1, 2, 3] triazole-1-yl] acetate) and (2H-benzo [d] [1, 2, 3] triazole -1-yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and ¹H-NMR spectroscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on Streptococcus aureus and Esteria coli. The present investigation deals with the synthesized compounds possessing good antimicrobial activity.

Keywords

Esterification, Benztriazole, Antimicrobial Activity.

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