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Shahar Yar, M.
- Antidepressant, Analgesic Activity and SAR Studies of Substituted Benzimidazoles
Abstract Views :263 |
PDF Views:2
Authors
Nadeem Siddiqui
1,
Md Shamsher Alam
1,
Meeta Sahu
1,
M. Shahar Yar
1,
Ozair Alam
1,
Mohammad Jamshed Ahmad Siddiqui
2
Affiliations
1 Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi-110062, IN
2 Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University, Malaysia, Kuantan 25200, MY
1 Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi-110062, IN
2 Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University, Malaysia, Kuantan 25200, MY
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 3 (2016), Pagination: 170-174Abstract
Purpose. Benzimidazole class of compound is found to have diverse biological properties. From the literature study, it is observed that depression is a severe mental disease affecting a huge population and pain is affecting about 20% of world population. In continuation of our previous research work, we selected benzimidazole pharmacophore to further explore its pharmacological activities. Methods. Forced swim test and Thermal stimulus test were used to assess the antidepressant and analgesic activity of synthesized benzimidazole analogs. Results. The antidepressant activity results showed that compound 3j was found most potent having Mean ± SEM value 21.6 ± 0.8 for treated group. Furthermore, in the analgesic test, 3b, 3j, and 3o showed Mean ± SEM values; 1.8 ± 0.10, 2.3 ± 0.10 and 2.2 ± 0.10, respectively. The study results suggested that these compounds could be explored further for the development of better antidepressant and analgesic agents. Conclusion. From the present study, it may be concluded that these active benzimidazole derivatives have been found to possess potential antidepressant and analgesic activity.Keywords
Benzimidazole, Antidepressant, Analgesic, Structure Activity Relationship, Log P.- Chemical Investigation of Polygonatum verticillatum
Abstract Views :224 |
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Authors
Affiliations
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN
3 Govt. P.G. College, Hamirpur (U.P), IN
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN
3 Govt. P.G. College, Hamirpur (U.P), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 20-21Abstract
Polygonatum verticillatum, Convallariaceae erect glabrous herb upto 20 cm. in height with thick ischolar_main stock. Upper part of the stem the leafy zig-zag grooved, leaves whorled sensible linear or lanceolate flowers 2-3 together, white, pinkish and white or pale green in whorled racemes fruits berries, red when ripe. Root stock is sweet, cooling, Emollient, Diuretic aphrodisiac, galactogogue, appetizing, tonic. It is useful in vitiated condition of pitas and vat, burning sensation fever, stongury, seminal weakness, anorexia and general debility. The author have done some work and isolated few higher fatty acids from the rhizome of this plant.- Synthesis and Evaluation of Pyrrole Derivative Conjugates of Aspirin as Anti-Platelet Agents
Abstract Views :231 |
PDF Views:0
Authors
Saurabh Chaturvedi
1,
Rakesh Saini
1,
A. N. Kesari
1,
Awani Rai
1,
Neelotma Maurya
1,
M. Shahar Yar
2
Affiliations
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN
1 Pranveer Singh Institute of Technology, Bhauti, Kanpur-208020, (U.P), IN
2 Jamiya Hamdard University, New Delhi, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 22-25Abstract
A new series of NSAID’S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.Keywords
NSAID’S, Aspirin, Anti-Platelet Agents, Pyrrole.- Synthesis and Biological Evaluation of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles
Abstract Views :230 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, IN
2 Department of Pharmacy, Jamia Hamdurd, New Delhi, IN
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, IN
2 Department of Pharmacy, Jamia Hamdurd, New Delhi, IN