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Pradhan, Madhulika
- Treatment Strategies in Burn Wounds: An Overview
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Authors
Deependra Singh
1,
Mukesh K. Nag
1,
Satish Patel
1,
Madhulika Pradhan
1,
Shikha Shrivastava
1,
S. J. Daharwal
1,
Manju R. Singh
1
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 6 (2013), Pagination: 341-352Abstract
Wound healing involves a regulated sequence of cellular activity. These activities provide the foundation for the mechanisms of wound repair. Successful wound care involves optimizing local and systemic conditions in combination with an ideal wound healing environment. The basic steps of wound management are prevention of wound contamination, debridement of dead and dying tissue, removal of debris and contaminants, provision of adequate wound drainage, promotion of a viable vascular bed and selection of an appropriate method of closure. A wide variety of preparations and remedies of non-organic, organic, biogenic, and phytogenic origin have been devised and used in the topical treatment of burns. Many different strategies have been developed to influence this wound environment to provide a pathogen-free, protected, and moist area for healing to occur. This review discusses the physiology, type and management of burn wounds and future directions for this field.References
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- Development and Validation of a Robust RP-HPLC Method for Analysis of Calcipotriol in Pharmaceutical Dosage Form
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Authors
Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka, Kurud Road, Bhilai, Chhattisgarh-490024, IN
1 Rungta College of Pharmaceutical Sciences and Research, Kohka, Kurud Road, Bhilai, Chhattisgarh-490024, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 579-583Abstract
Calcipotriol is a very efficient drug used in the treatment of psoriasis. In present work a novel, hasty, effortless and cost-effective Reversed -Phase High-Performance Thin-Layer Chromatography (RP-HPTLC) technique has been developed and subsequently validated for quantitative assessment of calcipotriol in bulk and in ointment. Optimized chromatographic condition was employed to accomplish separation on a Phenomenex Luna C18 column (250mm X 4.6 mm in diameter) with typical particle size of 5μ column employing Shimadzu HPLC system. Mobile phase constituting of methanol: water (80:20, v/v) was pumped during the chromatographic separation at 1 mL/min flow rate and detection was made by ultraviolet‑visible detector at 264 nm. The method was validated for linearity, precision, robustness, accuracy, limit of detection and limit of quantification as per guidelines of International conference on Harmonization (ICH). The method resulted into sharp and well resolved peak for Calcipotriol at 8.2 min retention time. Method was also found to be linear (regression coefficient: 0.999), accurate (average recovery: 100%), precise and robust. Thus the developed analytical method is acceptable for identification and quantitative estimation of calcipotriol in bulk formulation and ointment formulation.Keywords
Calcipotriol, Liquid Chromatography, Validation, Retention Time.References
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