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Panda, Madhusmita
- In silico Docking Studies on Cytochrome P450 Enzymes of Helicoverpa armigera (Hubner) and Trichogramma cacoeciae Marchal and Implications for Insecticide Detoxification
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PDF Views:150
Authors
K. P. Dhanya
1,
Madhusmita Panda
1,
S. K. Jalali
1,
N. K. Krishna Kumar
1,
R. Gandhi Gracy
1,
T. Venkatesan
1,
M. Nagesh
1
Affiliations
1 Molecular Entomology Laboratory, National Bureau of Agriculturally Important Insects, Post Bag No. 2491, H. A. Farm Post, Bellary Road, Hebbal, Bangalore 560 024, Karnataka, IN
1 Molecular Entomology Laboratory, National Bureau of Agriculturally Important Insects, Post Bag No. 2491, H. A. Farm Post, Bellary Road, Hebbal, Bangalore 560 024, Karnataka, IN
Source
Journal of Biological Control, Vol 27, No 1 (2013), Pagination: 1-9Abstract
In silico docking of cytochrome P450 monooxygenase (CYP450) of an insect, Helicoverpa armigera (Hübner) and a parasitoid, Trichogramma cacoeciae Marchal was studied with two insecticides, monocrotophos and fenvalerate. The CYP450 sequences of H. armigera (CYP9A12), T. cacoeciae (CYP4G12) and a human microsomal sequence CYP3A4, as positive control were retrieved from NCBI’s GenBank database. The structure, as predicted by SOPMA, of CYP450 in H. armigera contained 78.7% helix and 43.3% sheets, while that of T. cacoeciae contained 60.6% helix and 68.5% sheets. The three-dimensional molecular models of CYP450 of H. armigera and T. cacoeciae indicated that 96.5 and 97.2% residues, respectively, were in the most favored region. The docking studies revealed that the binding energy of H. armigera was -3.50 and -7.65 kcal/mole compared to the binding energy of T. cacoeciae -2.96 and -5.28 kcal/mole for monocrotophos and fenvalerate, respectively, inferring stronger interaction of H. armigera CYP450 with the insecticides and thereby higher potential for resistance in H. armigera.Keywords
Cytochrome P450, Helicoverpa armigera, Trichogramma cacoeciae, In silico Molecular Docking.References
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- Emotional Intelligence & Prosocial Behaviour: Multidimensional Trait Analysis of Technical Students
Abstract Views :499 |
PDF Views:2
Authors
Lalatendu Kesari Jena
1,
Pratishtha Bhattacharya
1,
Lopamudra Hati
1,
Dona Ghosh
1,
Madhusmita Panda
1
Affiliations
1 Dept. of Humanities and Social Science, IIT-Kharagpur, West Bengal, IN
1 Dept. of Humanities and Social Science, IIT-Kharagpur, West Bengal, IN
Source
Journal of Strategic Human Resource Management, Vol 3, No 2 (2014), Pagination: 38-47Abstract
While trying to interpret the intricate mechanism working behind an individual's willingness to help others, we often lose our way right into the heart of myriads of psychological concepts of significance like disposition, emotion, intelligence and many such. It is observed that the internal motivation to engage in a helping behaviour does not occur in an isolated way, rather it occurs as an important conjunction of certain significant factors. In this connection there happens to be the semblance of "emotional intelligence" and "prosocial behaviour" in academic and later professional success which has been found unaccounted in literature; and hence usage of the variables to find out the connecting patterns has encouraged the doctoral scholars to investigate the predictors, including personality traits of postgraduate students and research scholars of premier institutions of national importance spearheading technical education in Eastern India.Keywords
Well-Being, Self-Control, Emotionality, Sociability, Other-Oriented Empathy, Helpfulness.References
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