Informatics Publishing Limited

Meenakshi Bhatia ¹, Renu Mogra ²

Affiliations
1 Department of Foods and Nutrition, College of Home Science,maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan, IN
2 Department of Foods and Nutrition, College of Home Science, Maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan, IN

Abstract

The present study aimed to prepare a weaning mix using malted pearl millet and malted wheat. To find out the acceptability of weaning mix sensory evaluation was done. The acceptability scores ranged between 7 to 8 for different sensory characteristics. Bulk density, wettability, water absorption capacity, swelling capacity, solubility was found to be 0.62 g/ ml, 14.33 seconds, 60%, 4 g per cent, 19.66, respectively. Proximate composition of weaning mix revealed 3.01 g/100 g, 11.66g/100 g, 2.51 g/100g, 2.51 g/100g, 0.41g/ 100g, 79.06 g/100g and 392 Kcal/100g for moisture, protein, fat, ash, fibre, carbohydrate and energy, respectively. Total iron content was found to be 6.93 mg/100 g and bio available iron was 5.66 mg/100 g. The per cent availability of iron was found 81.67 per cent. Phytic acid content was found to be 39.84 mg/100g while Vitamin C content of weaning mix was 11.77 mg/100g. The microbial count was also found in safer limit less than 50,000 per g of sample according to Indian Standard Value safe for consumption. Peroxide value was also found in safe limit no rancid taste was found during organoleptic evaluation of weaning mix at 0th day and 30th day of storage.

Keywords

Quality Evaluation, Iron,weaning Mix

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Sarita Garg ¹, Meenakshi Bhatia ², Pradeep Kumar ³

Affiliations
1 Division of Pharmaceutics, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana, IN
2 Division of Pharmaceutics, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana, IN
3 Chitkara College of Pharmacy, Chandigarh Patiala National Highway, Rajpura-140401, Patiala, Punjab, IN

Abstract

The present study was undertaken to evaluate the effect of different viscosity grades of polyoxyethylene, their content level and the method of tablet preparation on the release profile of cephalexin trihydrate from matrix systems. Matrix tablets were prepared using Polyox N-10, Polyox N-80, Polyox N-60 K, Polyox 301 and Polyox 303 as rate-retarding agents by direct compression process. The release of drug from these hydrophillic matrices was studied over 12-hours in buffer media of pH 1.2. Statistically significant difference was found among the drug release profile from different matrices. The release kinetics was found to be governed by the type and content of hydrophillic materials in the matrix. Tablets granulated by PVP K-30 solution have higher hardness than those prepared by direct compression. However, drug release was not influenced by the method of tablet preparation. Formulations containing Polyox N-60K, Polyox 301 and Polyox 303 released 82%, 76% and 70% of the drug respectively, indicating that increasing viscosity can drastically reduce the release rate. Further, a decrease in polymer concentrations resulted a slight increase in thickness and friability, while a increase in polymer level resulted a increase in hardness and decrease in release rate. Numerical fits indicated that the formulations followed the Zero order release pattern which was further confirmed by the domination of super case-II transport in polyox tablets.

Keywords

Polyoxyethylene, Cephalexin Trihydrate, Hydrophilic Matrix, Release Kinetics.

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